Efficacy and safety profile of once-weekly dulaglutide in type 2 diabetes: a report on the emerging new data
Anne J Kugler,1 Michael L Thiman2 1Department of Pharmacy Practice and Administration, Western University of Health Sciences College of Pharmacy, Pomona, CA, USA; 2Department of Clinical and Administrative Pharmacy, University of Georgia College of Pharmacy, Athens, GA, USA Abstract: Dulaglutide is...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-05-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Subjects: | |
| Online Access: | https://www.dovepress.com/efficacy-and-safety-profile-of-once-weekly-dulaglutide-in-type-2-diabe-peer-reviewed-article-DMSO |
| _version_ | 1797936116878278656 |
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| author | Kugler AJ Thiman ML |
| author_facet | Kugler AJ Thiman ML |
| author_sort | Kugler AJ |
| collection | DOAJ |
| description | Anne J Kugler,1 Michael L Thiman2 1Department of Pharmacy Practice and Administration, Western University of Health Sciences College of Pharmacy, Pomona, CA, USA; 2Department of Clinical and Administrative Pharmacy, University of Georgia College of Pharmacy, Athens, GA, USA Abstract: Dulaglutide is a once-weekly glucagon-like peptide-1 receptor agonist, which has been on the market in the USA since 2014. Dulaglutide has performed well in head-to-head studies against metformin, glargine, and sitagliptin, where its A1c lowering ranged from -0.78% to –1.64% over 52–104 weeks, and it consistently outperformed each of these agents. As an add-on therapy, dulaglutide provided additional A1c lowering of –1.4% to –1.44% over monotherapy with glimepiride or glargine at 24 and 28 weeks, respectively. Dulaglutide outperformed exenatide when added to a regimen of metformin with pioglitazone as well as glargine when added to a regimen of metformin with glimepiride. Dulaglutide was shown to be non-inferior to liraglutide when added to metformin. In all AWARD studies other than when compared to liraglutide, dulaglutide at full strength resulted in significantly more patients achieving their A1c goal. Recent class-wide meta-analyses indicate that the incidence of commonly experienced gastrointestinal (GI) side effects is dose dependent, and nausea and vomiting are less common in longer-acting agents such as dulaglutide, but diarrhea may be more common. Pooled data have shown no increased risk of serious side effects such as pancreatitis or neoplasm with the use of dulaglutide. Given the evidence supporting liraglutide’s cardiovascular benefits, the highly anticipated REWIND trial will have a significant impact on the future place in the therapy of dulaglutide. Keywords: GLP-1 RA, glucagon-like peptide-1 receptor agonist, antidiabetic drugs, diabetes mellitus, injectable, incretin |
| first_indexed | 2024-04-10T18:25:43Z |
| format | Article |
| id | doaj.art-96492cf1c8914c96864b80eead4d4fe9 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T18:25:43Z |
| publishDate | 2018-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-96492cf1c8914c96864b80eead4d4fe92023-02-02T06:01:03ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072018-05-01Volume 1118719738232Efficacy and safety profile of once-weekly dulaglutide in type 2 diabetes: a report on the emerging new dataKugler AJThiman MLAnne J Kugler,1 Michael L Thiman2 1Department of Pharmacy Practice and Administration, Western University of Health Sciences College of Pharmacy, Pomona, CA, USA; 2Department of Clinical and Administrative Pharmacy, University of Georgia College of Pharmacy, Athens, GA, USA Abstract: Dulaglutide is a once-weekly glucagon-like peptide-1 receptor agonist, which has been on the market in the USA since 2014. Dulaglutide has performed well in head-to-head studies against metformin, glargine, and sitagliptin, where its A1c lowering ranged from -0.78% to –1.64% over 52–104 weeks, and it consistently outperformed each of these agents. As an add-on therapy, dulaglutide provided additional A1c lowering of –1.4% to –1.44% over monotherapy with glimepiride or glargine at 24 and 28 weeks, respectively. Dulaglutide outperformed exenatide when added to a regimen of metformin with pioglitazone as well as glargine when added to a regimen of metformin with glimepiride. Dulaglutide was shown to be non-inferior to liraglutide when added to metformin. In all AWARD studies other than when compared to liraglutide, dulaglutide at full strength resulted in significantly more patients achieving their A1c goal. Recent class-wide meta-analyses indicate that the incidence of commonly experienced gastrointestinal (GI) side effects is dose dependent, and nausea and vomiting are less common in longer-acting agents such as dulaglutide, but diarrhea may be more common. Pooled data have shown no increased risk of serious side effects such as pancreatitis or neoplasm with the use of dulaglutide. Given the evidence supporting liraglutide’s cardiovascular benefits, the highly anticipated REWIND trial will have a significant impact on the future place in the therapy of dulaglutide. Keywords: GLP-1 RA, glucagon-like peptide-1 receptor agonist, antidiabetic drugs, diabetes mellitus, injectable, incretinhttps://www.dovepress.com/efficacy-and-safety-profile-of-once-weekly-dulaglutide-in-type-2-diabe-peer-reviewed-article-DMSOGLP-1 RAglucagon-like peptide-1 receptor agonistantidiabetic drugsdiabetes mellitusinjectableincretin |
| spellingShingle | Kugler AJ Thiman ML Efficacy and safety profile of once-weekly dulaglutide in type 2 diabetes: a report on the emerging new data Diabetes, Metabolic Syndrome and Obesity GLP-1 RA glucagon-like peptide-1 receptor agonist antidiabetic drugs diabetes mellitus injectable incretin |
| title | Efficacy and safety profile of once-weekly dulaglutide in type 2 diabetes: a report on the emerging new data |
| title_full | Efficacy and safety profile of once-weekly dulaglutide in type 2 diabetes: a report on the emerging new data |
| title_fullStr | Efficacy and safety profile of once-weekly dulaglutide in type 2 diabetes: a report on the emerging new data |
| title_full_unstemmed | Efficacy and safety profile of once-weekly dulaglutide in type 2 diabetes: a report on the emerging new data |
| title_short | Efficacy and safety profile of once-weekly dulaglutide in type 2 diabetes: a report on the emerging new data |
| title_sort | efficacy and safety profile of once weekly dulaglutide in type 2 diabetes a report on the emerging new data |
| topic | GLP-1 RA glucagon-like peptide-1 receptor agonist antidiabetic drugs diabetes mellitus injectable incretin |
| url | https://www.dovepress.com/efficacy-and-safety-profile-of-once-weekly-dulaglutide-in-type-2-diabe-peer-reviewed-article-DMSO |
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