Monoclonal Antibodies as SARS-CoV-2 Serology Standards: Experimental Validation and Broader Implications for Correlates of Protection

Monoclonal Antibodies as SARS-CoV-2 Serology Standards: Experimental Validation and Broader Implications for Correlates of Protection

COVID-19 has highlighted challenges in the measurement quality and comparability of serological binding and neutralization assays. Due to many different assay formats and reagents, these measurements are known to be highly variable with large uncertainties. The development of the WHO international s...

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Bibliographic Details
Main Authors: Lili Wang, Paul N. Patrone, Anthony J. Kearsley, Jerilyn R. Izac, Adolfas K. Gaigalas, John C. Prostko, Hyung Joon Kwon, Weichun Tang, Martina Kosikova, Hang Xie, Linhua Tian, Elzafir B. Elsheikh, Edward J. Kwee, Troy Kemp, Simon Jochum, Natalie Thornburg, L. Clifford McDonald, Adi V. Gundlapalli, Sheng Lin-Gibson
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:International Journal of Molecular Sciences
Subjects:
SARS-CoV-2
spike protein
serological binding assay
neutralization assay
WHO international standard (WHO IS)
monoclonal antibody
Online Access:https://www.mdpi.com/1422-0067/24/21/15705

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