The simplicity of protein sequence-function relationships
Abstract How complex are the rules by which a protein’s sequence determines its function? High-order epistatic interactions among residues are thought to be pervasive, suggesting an idiosyncratic and unpredictable sequence-function relationship. But many prior studies may have overestimated epistasi...
| Päätekijät: | , , |
|---|---|
| Aineistotyyppi: | Artikkeli |
| Kieli: | English |
| Julkaistu: |
Nature Portfolio
2024-09-01
|
| Sarja: | Nature Communications |
| Linkit: | https://doi.org/10.1038/s41467-024-51895-5 |