The effects of L-carnitine supplementation on inflammation, oxidative stress, and clinical outcomes in critically Ill patients with sepsis: a randomized, double-blind, controlled trial
Abstract Background Sepsis, a life-threatening organ dysfunction caused by a host’s dysregulated response to infection with an inflammatory process, becomes a real challenge for the healthcare systems. L-carnitine (LC) has antioxidant and anti-inflammatory properties as in previous studies. Thus, we...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Nutrition Journal |
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| Online Access: | https://doi.org/10.1186/s12937-024-00934-4 |
| _version_ | 1797266919971094528 |
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| author | Mahdi Keshani Babak Alikiaii Zahra Babaei Gholamreza Askari Zahra Heidari Manoj Sharma Mohammad Bagherniya |
| author_facet | Mahdi Keshani Babak Alikiaii Zahra Babaei Gholamreza Askari Zahra Heidari Manoj Sharma Mohammad Bagherniya |
| author_sort | Mahdi Keshani |
| collection | DOAJ |
| description | Abstract Background Sepsis, a life-threatening organ dysfunction caused by a host’s dysregulated response to infection with an inflammatory process, becomes a real challenge for the healthcare systems. L-carnitine (LC) has antioxidant and anti-inflammatory properties as in previous studies. Thus, we aimed to determine the effects of LC on inflammation, oxidative stress, and clinical parameters in critically ill septic patients. Methods A randomized double-blinded controlled trial was conducted. A total of 60 patients were randomized to receive LC (3 g/day, n = 30) or placebo (n = 30) for 7 days. Inflammatory and oxidative stress parameters (C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), superoxide dismutase (SOD), malondialdehyde (MDA), total antioxidant capacity (TAC), 28-day mortality rate, and some monitoring variables were evaluated. Results There was no statistically significant difference between study arms in baseline characteristics and disease severity scores. CRP (p < 0.001) and ESR (p: 0.004) significantly reduced, and SOD (p < 0.001) and TAC (p < 0.001) significantly improved in the LC group after 7 days. Between-group analysis revealed a significant reduction in CRP (p: 0.001) and serum chloride (p: 0.032), an increase in serum albumin (p: 0.036) and platelet (p: 0.004) significantly, and an increase in SOD marginally (p: 0.073). The 28-day mortality rate was also lower in the LC group compared with placebo (7 persons vs. 15 persons) significantly (odds ratio: 0.233, p: 0.010). Conclusions L-carnitine ameliorated inflammation, enhanced antioxidant defense, reduced mortality, and improved some clinical outcomes in critically ill patients with sepsis. Trial registration IRCT20201129049534N1; May 2021. |
| first_indexed | 2024-04-25T01:08:21Z |
| format | Article |
| id | doaj.art-964a35aaf7f04ec88a416a2f97445837 |
| institution | Directory Open Access Journal |
| issn | 1475-2891 |
| language | English |
| last_indexed | 2024-04-25T01:08:21Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition Journal |
| spelling | doaj.art-964a35aaf7f04ec88a416a2f974458372024-03-10T12:06:26ZengBMCNutrition Journal1475-28912024-03-0123111510.1186/s12937-024-00934-4The effects of L-carnitine supplementation on inflammation, oxidative stress, and clinical outcomes in critically Ill patients with sepsis: a randomized, double-blind, controlled trialMahdi Keshani0Babak Alikiaii1Zahra Babaei2Gholamreza Askari3Zahra Heidari4Manoj Sharma5Mohammad Bagherniya6Nutrition and Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical SciencesAnesthesia and Critical Care Research Center, Isfahan University of Medical SciencesDepartment of Nursing and Midwifery, Islamic Azad University Isfahan (Khorasgan) BranchNutrition and Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical SciencesDepartment of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical SciencesDepartment of Social & Behavioral Health, School of Public Health, & Department of Internal Medicine, University of NevadaNutrition and Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical SciencesAbstract Background Sepsis, a life-threatening organ dysfunction caused by a host’s dysregulated response to infection with an inflammatory process, becomes a real challenge for the healthcare systems. L-carnitine (LC) has antioxidant and anti-inflammatory properties as in previous studies. Thus, we aimed to determine the effects of LC on inflammation, oxidative stress, and clinical parameters in critically ill septic patients. Methods A randomized double-blinded controlled trial was conducted. A total of 60 patients were randomized to receive LC (3 g/day, n = 30) or placebo (n = 30) for 7 days. Inflammatory and oxidative stress parameters (C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), superoxide dismutase (SOD), malondialdehyde (MDA), total antioxidant capacity (TAC), 28-day mortality rate, and some monitoring variables were evaluated. Results There was no statistically significant difference between study arms in baseline characteristics and disease severity scores. CRP (p < 0.001) and ESR (p: 0.004) significantly reduced, and SOD (p < 0.001) and TAC (p < 0.001) significantly improved in the LC group after 7 days. Between-group analysis revealed a significant reduction in CRP (p: 0.001) and serum chloride (p: 0.032), an increase in serum albumin (p: 0.036) and platelet (p: 0.004) significantly, and an increase in SOD marginally (p: 0.073). The 28-day mortality rate was also lower in the LC group compared with placebo (7 persons vs. 15 persons) significantly (odds ratio: 0.233, p: 0.010). Conclusions L-carnitine ameliorated inflammation, enhanced antioxidant defense, reduced mortality, and improved some clinical outcomes in critically ill patients with sepsis. Trial registration IRCT20201129049534N1; May 2021.https://doi.org/10.1186/s12937-024-00934-4L-carnitineSepsisInflammationOxidative stressMortalityClinical trial |
| spellingShingle | Mahdi Keshani Babak Alikiaii Zahra Babaei Gholamreza Askari Zahra Heidari Manoj Sharma Mohammad Bagherniya The effects of L-carnitine supplementation on inflammation, oxidative stress, and clinical outcomes in critically Ill patients with sepsis: a randomized, double-blind, controlled trial Nutrition Journal L-carnitine Sepsis Inflammation Oxidative stress Mortality Clinical trial |
| title | The effects of L-carnitine supplementation on inflammation, oxidative stress, and clinical outcomes in critically Ill patients with sepsis: a randomized, double-blind, controlled trial |
| title_full | The effects of L-carnitine supplementation on inflammation, oxidative stress, and clinical outcomes in critically Ill patients with sepsis: a randomized, double-blind, controlled trial |
| title_fullStr | The effects of L-carnitine supplementation on inflammation, oxidative stress, and clinical outcomes in critically Ill patients with sepsis: a randomized, double-blind, controlled trial |
| title_full_unstemmed | The effects of L-carnitine supplementation on inflammation, oxidative stress, and clinical outcomes in critically Ill patients with sepsis: a randomized, double-blind, controlled trial |
| title_short | The effects of L-carnitine supplementation on inflammation, oxidative stress, and clinical outcomes in critically Ill patients with sepsis: a randomized, double-blind, controlled trial |
| title_sort | effects of l carnitine supplementation on inflammation oxidative stress and clinical outcomes in critically ill patients with sepsis a randomized double blind controlled trial |
| topic | L-carnitine Sepsis Inflammation Oxidative stress Mortality Clinical trial |
| url | https://doi.org/10.1186/s12937-024-00934-4 |
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