The Role of Podoplanin in the Immune System and Inflammation
Zhiyuan Zhang,* Nan Zhang,* Jing Yu,* Wenting Xu, Jiameng Gao, Xin Lv, Zongmei Wen Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200433, People’s Republic of China*These authors contributed equally to this...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2022-06-01
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| Series: | Journal of Inflammation Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/the-role-of-podoplanin-in-the-immune-system-and-inflammation-peer-reviewed-fulltext-article-JIR |
| _version_ | 1811337586795347968 |
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| author | Zhang Z Zhang N Yu J Xu W Gao J Lv X Wen Z |
| author_facet | Zhang Z Zhang N Yu J Xu W Gao J Lv X Wen Z |
| author_sort | Zhang Z |
| collection | DOAJ |
| description | Zhiyuan Zhang,* Nan Zhang,* Jing Yu,* Wenting Xu, Jiameng Gao, Xin Lv, Zongmei Wen Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200433, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xin Lv; Zongmei Wen, Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zhengmin Road, Shanghai, 200433, People’s Republic of China, Email xinlvg@126.com; wzm1103@126.comAbstract: Podoplanin is a small cell-surface mucin-like glycoprotein that participates in multiple physiological and pathological processes. Podoplanin exerts an important function in the immune response and is upregulated in fibroblasts, macrophages, T helper cells, and epithelial cells during inflammation. Herein, we summarize the latest knowledge on the functional expression of podoplanin in the immune system and review the contribution of podoplanin to several inflammatory diseases. Furthermore, we discuss podoplanin as a novel therapeutic target for various inflammatory diseases.Keywords: podoplanin, immune system, inflammation |
| first_indexed | 2024-04-13T17:57:12Z |
| format | Article |
| id | doaj.art-964b85f4e6564a3294532bc4cd360fee |
| institution | Directory Open Access Journal |
| issn | 1178-7031 |
| language | English |
| last_indexed | 2024-04-13T17:57:12Z |
| publishDate | 2022-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj.art-964b85f4e6564a3294532bc4cd360fee2022-12-22T02:36:26ZengDove Medical PressJournal of Inflammation Research1178-70312022-06-01Volume 153561357276009The Role of Podoplanin in the Immune System and InflammationZhang ZZhang NYu JXu WGao JLv XWen ZZhiyuan Zhang,* Nan Zhang,* Jing Yu,* Wenting Xu, Jiameng Gao, Xin Lv, Zongmei Wen Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200433, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xin Lv; Zongmei Wen, Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zhengmin Road, Shanghai, 200433, People’s Republic of China, Email xinlvg@126.com; wzm1103@126.comAbstract: Podoplanin is a small cell-surface mucin-like glycoprotein that participates in multiple physiological and pathological processes. Podoplanin exerts an important function in the immune response and is upregulated in fibroblasts, macrophages, T helper cells, and epithelial cells during inflammation. Herein, we summarize the latest knowledge on the functional expression of podoplanin in the immune system and review the contribution of podoplanin to several inflammatory diseases. Furthermore, we discuss podoplanin as a novel therapeutic target for various inflammatory diseases.Keywords: podoplanin, immune system, inflammationhttps://www.dovepress.com/the-role-of-podoplanin-in-the-immune-system-and-inflammation-peer-reviewed-fulltext-article-JIRpodoplaninimmune systeminflammation |
| spellingShingle | Zhang Z Zhang N Yu J Xu W Gao J Lv X Wen Z The Role of Podoplanin in the Immune System and Inflammation Journal of Inflammation Research podoplanin immune system inflammation |
| title | The Role of Podoplanin in the Immune System and Inflammation |
| title_full | The Role of Podoplanin in the Immune System and Inflammation |
| title_fullStr | The Role of Podoplanin in the Immune System and Inflammation |
| title_full_unstemmed | The Role of Podoplanin in the Immune System and Inflammation |
| title_short | The Role of Podoplanin in the Immune System and Inflammation |
| title_sort | role of podoplanin in the immune system and inflammation |
| topic | podoplanin immune system inflammation |
| url | https://www.dovepress.com/the-role-of-podoplanin-in-the-immune-system-and-inflammation-peer-reviewed-fulltext-article-JIR |
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