Norovirus infection among HIV-infected patients in Abuja, Nigeria: impact of combination antiretroviral therapy status
Abstract Background Norovirus is now recognized to be major cause of gastroenteritis worldwide, with significantly higher disease burden among immunocompromised patients. This study aimed to determine the prevalence of Norovirus among HIV-infected patients and to evaluate the impact of combination a...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-09-01
|
| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-023-08592-3 |
| _version_ | 1797453752728289280 |
|---|---|
| author | Favour Osazuwa William Olayemi Johnson Hailey Seth Grobler |
| author_facet | Favour Osazuwa William Olayemi Johnson Hailey Seth Grobler |
| author_sort | Favour Osazuwa |
| collection | DOAJ |
| description | Abstract Background Norovirus is now recognized to be major cause of gastroenteritis worldwide, with significantly higher disease burden among immunocompromised patients. This study aimed to determine the prevalence of Norovirus among HIV-infected patients and to evaluate the impact of combination antiretroviral therapy (cART) status on Norovirus prevalence in a sub-urban area of Abuja, Nigeria. Methods This study included a total of Two hundred and fifteen subjects (85 cART-naïve and 130 cART-exposed) HIV-infected patients. Age range of study participants was 18 to 60 years. Faecal specimens where collected in screw capped containers and analyzed for Norovirus using Accupower Norovirus real-time PCR Test kit. CD4 + cell count was determined using flow cytometry. Results The prevalence of Norovirus among cART-naïve HIV-infected patients was 10.6%. Age and gender was not associated with norovirus infection. cART –naïve HIV-infected patients with CD4 + cell count < 200 was significantly more infected with Norovirus as compared to those with CD4 + count ≥ 200 (OR: 28.000, 95% CI 3.2237, 243.2007, P = 0.0025). Norovirus was also found to be significantly higher in cART-naïve HIV-infected patients than amongst cART-exposed counterparts (OR: 6.882, 95% CI: 1.4514, 32.6343, P = 0.015). Conclusions The prevalence of Norovirus among cART-naïve HIV-infected patients was high; and was significantly higher in subjects with low CD4 + counts. Screening for Norovirus among cART-naïve HIV-infected patients is however emphasized to allow for effective Norovirus disease management. |
| first_indexed | 2024-03-09T15:27:24Z |
| format | Article |
| id | doaj.art-964e8fc03b194377807b9211e74a271e |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-03-09T15:27:24Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-964e8fc03b194377807b9211e74a271e2023-11-26T12:26:51ZengBMCBMC Infectious Diseases1471-23342023-09-012311410.1186/s12879-023-08592-3Norovirus infection among HIV-infected patients in Abuja, Nigeria: impact of combination antiretroviral therapy statusFavour Osazuwa0William Olayemi Johnson1Hailey Seth Grobler2Department of Medical Laboratory Sciences, University of BeninMDS Molecular Services, Sub-Saharan African OfficeMDS Molecular Services, Sub-Saharan African OfficeAbstract Background Norovirus is now recognized to be major cause of gastroenteritis worldwide, with significantly higher disease burden among immunocompromised patients. This study aimed to determine the prevalence of Norovirus among HIV-infected patients and to evaluate the impact of combination antiretroviral therapy (cART) status on Norovirus prevalence in a sub-urban area of Abuja, Nigeria. Methods This study included a total of Two hundred and fifteen subjects (85 cART-naïve and 130 cART-exposed) HIV-infected patients. Age range of study participants was 18 to 60 years. Faecal specimens where collected in screw capped containers and analyzed for Norovirus using Accupower Norovirus real-time PCR Test kit. CD4 + cell count was determined using flow cytometry. Results The prevalence of Norovirus among cART-naïve HIV-infected patients was 10.6%. Age and gender was not associated with norovirus infection. cART –naïve HIV-infected patients with CD4 + cell count < 200 was significantly more infected with Norovirus as compared to those with CD4 + count ≥ 200 (OR: 28.000, 95% CI 3.2237, 243.2007, P = 0.0025). Norovirus was also found to be significantly higher in cART-naïve HIV-infected patients than amongst cART-exposed counterparts (OR: 6.882, 95% CI: 1.4514, 32.6343, P = 0.015). Conclusions The prevalence of Norovirus among cART-naïve HIV-infected patients was high; and was significantly higher in subjects with low CD4 + counts. Screening for Norovirus among cART-naïve HIV-infected patients is however emphasized to allow for effective Norovirus disease management.https://doi.org/10.1186/s12879-023-08592-3NoroviruscARTHIVCD4+ |
| spellingShingle | Favour Osazuwa William Olayemi Johnson Hailey Seth Grobler Norovirus infection among HIV-infected patients in Abuja, Nigeria: impact of combination antiretroviral therapy status BMC Infectious Diseases Norovirus cART HIV CD4+ |
| title | Norovirus infection among HIV-infected patients in Abuja, Nigeria: impact of combination antiretroviral therapy status |
| title_full | Norovirus infection among HIV-infected patients in Abuja, Nigeria: impact of combination antiretroviral therapy status |
| title_fullStr | Norovirus infection among HIV-infected patients in Abuja, Nigeria: impact of combination antiretroviral therapy status |
| title_full_unstemmed | Norovirus infection among HIV-infected patients in Abuja, Nigeria: impact of combination antiretroviral therapy status |
| title_short | Norovirus infection among HIV-infected patients in Abuja, Nigeria: impact of combination antiretroviral therapy status |
| title_sort | norovirus infection among hiv infected patients in abuja nigeria impact of combination antiretroviral therapy status |
| topic | Norovirus cART HIV CD4+ |
| url | https://doi.org/10.1186/s12879-023-08592-3 |
| work_keys_str_mv | AT favourosazuwa norovirusinfectionamonghivinfectedpatientsinabujanigeriaimpactofcombinationantiretroviraltherapystatus AT williamolayemijohnson norovirusinfectionamonghivinfectedpatientsinabujanigeriaimpactofcombinationantiretroviraltherapystatus AT haileysethgrobler norovirusinfectionamonghivinfectedpatientsinabujanigeriaimpactofcombinationantiretroviraltherapystatus |