STAT3 and p63 in the Regulation of Cancer Stemness
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor with many important functions in normal and transformed cells. STAT3 regulatory activities are highly complex as they are involved in various signaling pathways in different cell types under different conditions. Bi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.909251/full |
| _version_ | 1811320377897385984 |
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| author | Shixiong Wei Jialin Li Mingbo Tang Kewei Zhang Xinliang Gao Linan Fang Wei Liu |
| author_facet | Shixiong Wei Jialin Li Mingbo Tang Kewei Zhang Xinliang Gao Linan Fang Wei Liu |
| author_sort | Shixiong Wei |
| collection | DOAJ |
| description | Signal transducer and activator of transcription 3 (STAT3) is a transcription factor with many important functions in normal and transformed cells. STAT3 regulatory activities are highly complex as they are involved in various signaling pathways in different cell types under different conditions. Biologically, STAT3 is a regulative factor for normal and cancer stem cells (CSCs). Tumor protein p63 (p63), a member of the p53 protein family, is involved in these biological processes and is also physically and functionally associated with STAT3. STAT3 activation occurs during various aspects of carcinogenesis, including regulation of CSCs properties. In combination with p63, STAT3 is a possible biological marker of CSCs and a major regulator of maintenance of stemness in CSCs. We summarized the STAT3 functions and regulation and its role in CSC properties and highlight how these are affected by its associations with p63. |
| first_indexed | 2024-04-13T12:58:46Z |
| format | Article |
| id | doaj.art-964f5303eaf642b5b861743694b8a030 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-13T12:58:46Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-964f5303eaf642b5b861743694b8a0302022-12-22T02:45:58ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-08-011310.3389/fgene.2022.909251909251STAT3 and p63 in the Regulation of Cancer StemnessShixiong WeiJialin LiMingbo TangKewei ZhangXinliang GaoLinan FangWei LiuSignal transducer and activator of transcription 3 (STAT3) is a transcription factor with many important functions in normal and transformed cells. STAT3 regulatory activities are highly complex as they are involved in various signaling pathways in different cell types under different conditions. Biologically, STAT3 is a regulative factor for normal and cancer stem cells (CSCs). Tumor protein p63 (p63), a member of the p53 protein family, is involved in these biological processes and is also physically and functionally associated with STAT3. STAT3 activation occurs during various aspects of carcinogenesis, including regulation of CSCs properties. In combination with p63, STAT3 is a possible biological marker of CSCs and a major regulator of maintenance of stemness in CSCs. We summarized the STAT3 functions and regulation and its role in CSC properties and highlight how these are affected by its associations with p63.https://www.frontiersin.org/articles/10.3389/fgene.2022.909251/fullSTAT3 (signal transducer and activator of transcription 3)P63 (TP63)cancerstemnesscancer stem cell |
| spellingShingle | Shixiong Wei Jialin Li Mingbo Tang Kewei Zhang Xinliang Gao Linan Fang Wei Liu STAT3 and p63 in the Regulation of Cancer Stemness Frontiers in Genetics STAT3 (signal transducer and activator of transcription 3) P63 (TP63) cancer stemness cancer stem cell |
| title | STAT3 and p63 in the Regulation of Cancer Stemness |
| title_full | STAT3 and p63 in the Regulation of Cancer Stemness |
| title_fullStr | STAT3 and p63 in the Regulation of Cancer Stemness |
| title_full_unstemmed | STAT3 and p63 in the Regulation of Cancer Stemness |
| title_short | STAT3 and p63 in the Regulation of Cancer Stemness |
| title_sort | stat3 and p63 in the regulation of cancer stemness |
| topic | STAT3 (signal transducer and activator of transcription 3) P63 (TP63) cancer stemness cancer stem cell |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.909251/full |
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