Deciphering the Relevance of Bone ECM Signaling
Bone mineral density, a bone matrix parameter frequently used to predict fracture risk, is not the only one to affect bone fragility. Other factors, including the extracellular matrix (ECM) composition and microarchitecture, are of paramount relevance in this process. The bone ECM is a noncellular t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/12/2630 |
| _version_ | 1827700629128085504 |
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| author | Natividad Alcorta-Sevillano Iratxe Macías Arantza Infante Clara I. Rodríguez |
| author_facet | Natividad Alcorta-Sevillano Iratxe Macías Arantza Infante Clara I. Rodríguez |
| author_sort | Natividad Alcorta-Sevillano |
| collection | DOAJ |
| description | Bone mineral density, a bone matrix parameter frequently used to predict fracture risk, is not the only one to affect bone fragility. Other factors, including the extracellular matrix (ECM) composition and microarchitecture, are of paramount relevance in this process. The bone ECM is a noncellular three-dimensional structure secreted by cells into the extracellular space, which comprises inorganic and organic compounds. The main inorganic components of the ECM are calcium-deficient apatite and trace elements, while the organic ECM consists of collagen type I and noncollagenous proteins. Bone ECM dynamically interacts with osteoblasts and osteoclasts to regulate the formation of new bone during regeneration. Thus, the composition and structure of inorganic and organic bone matrix may directly affect bone quality. Moreover, proteins that compose ECM, beyond their structural role have other crucial biological functions, thanks to their ability to bind multiple interacting partners like other ECM proteins, growth factors, signal receptors and adhesion molecules. Thus, ECM proteins provide a complex network of biochemical and physiological signals. Herein, we summarize different ECM factors that are essential to bone strength besides, discussing how these parameters are altered in pathological conditions related with bone fragility. |
| first_indexed | 2024-03-10T14:15:45Z |
| format | Article |
| id | doaj.art-964f6f6981054facb1d917a6c0ed955c |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T14:15:45Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-964f6f6981054facb1d917a6c0ed955c2023-11-20T23:47:27ZengMDPI AGCells2073-44092020-12-01912263010.3390/cells9122630Deciphering the Relevance of Bone ECM SignalingNatividad Alcorta-Sevillano0Iratxe Macías1Arantza Infante2Clara I. Rodríguez3Stem Cells and Cell Therapy Laboratory, Biocruces Bizkaia Health Research Institute, Cruces University Hospital, Plaza de Cruces S/N, Barakaldo, 48903 Bizkaia, SpainStem Cells and Cell Therapy Laboratory, Biocruces Bizkaia Health Research Institute, Cruces University Hospital, Plaza de Cruces S/N, Barakaldo, 48903 Bizkaia, SpainStem Cells and Cell Therapy Laboratory, Biocruces Bizkaia Health Research Institute, Cruces University Hospital, Plaza de Cruces S/N, Barakaldo, 48903 Bizkaia, SpainStem Cells and Cell Therapy Laboratory, Biocruces Bizkaia Health Research Institute, Cruces University Hospital, Plaza de Cruces S/N, Barakaldo, 48903 Bizkaia, SpainBone mineral density, a bone matrix parameter frequently used to predict fracture risk, is not the only one to affect bone fragility. Other factors, including the extracellular matrix (ECM) composition and microarchitecture, are of paramount relevance in this process. The bone ECM is a noncellular three-dimensional structure secreted by cells into the extracellular space, which comprises inorganic and organic compounds. The main inorganic components of the ECM are calcium-deficient apatite and trace elements, while the organic ECM consists of collagen type I and noncollagenous proteins. Bone ECM dynamically interacts with osteoblasts and osteoclasts to regulate the formation of new bone during regeneration. Thus, the composition and structure of inorganic and organic bone matrix may directly affect bone quality. Moreover, proteins that compose ECM, beyond their structural role have other crucial biological functions, thanks to their ability to bind multiple interacting partners like other ECM proteins, growth factors, signal receptors and adhesion molecules. Thus, ECM proteins provide a complex network of biochemical and physiological signals. Herein, we summarize different ECM factors that are essential to bone strength besides, discussing how these parameters are altered in pathological conditions related with bone fragility.https://www.mdpi.com/2073-4409/9/12/2630ECMbone fragilityfracture riskbone diseaseECM signaling |
| spellingShingle | Natividad Alcorta-Sevillano Iratxe Macías Arantza Infante Clara I. Rodríguez Deciphering the Relevance of Bone ECM Signaling Cells ECM bone fragility fracture risk bone disease ECM signaling |
| title | Deciphering the Relevance of Bone ECM Signaling |
| title_full | Deciphering the Relevance of Bone ECM Signaling |
| title_fullStr | Deciphering the Relevance of Bone ECM Signaling |
| title_full_unstemmed | Deciphering the Relevance of Bone ECM Signaling |
| title_short | Deciphering the Relevance of Bone ECM Signaling |
| title_sort | deciphering the relevance of bone ecm signaling |
| topic | ECM bone fragility fracture risk bone disease ECM signaling |
| url | https://www.mdpi.com/2073-4409/9/12/2630 |
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