Causal association between adiponectin and the risk of Alzheimer's disease: A Mendelian randomization study
BackgroundNumerous observational studies have revealed that circulating adiponectin (ADPN) is associated with Alzheimer's disease (AD) risk. However, the causality remains unknown. We aimed to assess the causality of circulating ADPN on AD risk using Mendelian randomization (MR).MethodsFourteen...
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.1038975/full |
| _version_ | 1811178317331562496 |
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| author | Tianyu Jin Tianyu Jin Wei Huang Fangzheng Cao Xinyue Yu Zhenhua Ying Shunyuan Guo Yifan Cheng Chao Xu |
| author_facet | Tianyu Jin Tianyu Jin Wei Huang Fangzheng Cao Xinyue Yu Zhenhua Ying Shunyuan Guo Yifan Cheng Chao Xu |
| author_sort | Tianyu Jin |
| collection | DOAJ |
| description | BackgroundNumerous observational studies have revealed that circulating adiponectin (ADPN) is associated with Alzheimer's disease (AD) risk. However, the causality remains unknown. We aimed to assess the causality of circulating ADPN on AD risk using Mendelian randomization (MR).MethodsFourteen single nucleotide polymorphisms (SNPs) significantly associated with ADPN were selected from publicly available genetic abstract data. We applied these SNPs to two recent large-scale genome-wide association studies (GWAS) of AD, one from the FinnGen consortium and the other from a large meta-analysis. The inverse variance weighted method, MR–Egger method, the weighted median method, the Cochran Q statistic, the MR-Pleiotropy Residual Sum and Outlier methods, and the leave-one-out analysis were applied for MR analyses.ResultsIn MR analysis, no significant genetic association was found between plasma ADPN levels and AD risk by analyzing the FinnGen consortium GWAS database in the inverse variance weighted method [odds ratio (OR): 0.874, 95% confidence interval (CI): 0.701–1.089, p = 0.230], MR–Egger (OR: 0.944, 95% CI: 0.692–1.288, p = 0.721), and weighted median method (OR: 0.900, 95% CI: 0.678–1.194, p = 0.449). Additionally, the same analysis was conducted for the meta-analysis database, and we found no significant association (OR: 1.000, 95% CI: 0.999–1.001, p = 0.683).ConclusionOur findings reveal no significant causal association between circulating ADPN and AD risk. |
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| language | English |
| last_indexed | 2024-04-11T06:17:37Z |
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| spelling | doaj.art-9650675840f74d2eb718b0ef2d4e7fc22022-12-22T04:41:01ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-12-011310.3389/fneur.2022.10389751038975Causal association between adiponectin and the risk of Alzheimer's disease: A Mendelian randomization studyTianyu Jin0Tianyu Jin1Wei Huang2Fangzheng Cao3Xinyue Yu4Zhenhua Ying5Shunyuan Guo6Yifan Cheng7Chao Xu8The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, ChinaCenter for Rehabilitation Medicine, Department of Neurology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, ChinaRheumatism and Immunity Research Institute, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, ChinaThe Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, ChinaAlberta Institute, Wenzhou Medical University, Wenzhou, ChinaRheumatism and Immunity Research Institute, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, ChinaCenter for Rehabilitation Medicine, Department of Neurology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, ChinaCenter for Rehabilitation Medicine, Department of Neurology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, ChinaCenter for Rehabilitation Medicine, Department of Neurology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, ChinaBackgroundNumerous observational studies have revealed that circulating adiponectin (ADPN) is associated with Alzheimer's disease (AD) risk. However, the causality remains unknown. We aimed to assess the causality of circulating ADPN on AD risk using Mendelian randomization (MR).MethodsFourteen single nucleotide polymorphisms (SNPs) significantly associated with ADPN were selected from publicly available genetic abstract data. We applied these SNPs to two recent large-scale genome-wide association studies (GWAS) of AD, one from the FinnGen consortium and the other from a large meta-analysis. The inverse variance weighted method, MR–Egger method, the weighted median method, the Cochran Q statistic, the MR-Pleiotropy Residual Sum and Outlier methods, and the leave-one-out analysis were applied for MR analyses.ResultsIn MR analysis, no significant genetic association was found between plasma ADPN levels and AD risk by analyzing the FinnGen consortium GWAS database in the inverse variance weighted method [odds ratio (OR): 0.874, 95% confidence interval (CI): 0.701–1.089, p = 0.230], MR–Egger (OR: 0.944, 95% CI: 0.692–1.288, p = 0.721), and weighted median method (OR: 0.900, 95% CI: 0.678–1.194, p = 0.449). Additionally, the same analysis was conducted for the meta-analysis database, and we found no significant association (OR: 1.000, 95% CI: 0.999–1.001, p = 0.683).ConclusionOur findings reveal no significant causal association between circulating ADPN and AD risk.https://www.frontiersin.org/articles/10.3389/fneur.2022.1038975/fullAlzheimer's diseaseadiponectincausalityMendelian randomizationrisk |
| spellingShingle | Tianyu Jin Tianyu Jin Wei Huang Fangzheng Cao Xinyue Yu Zhenhua Ying Shunyuan Guo Yifan Cheng Chao Xu Causal association between adiponectin and the risk of Alzheimer's disease: A Mendelian randomization study Frontiers in Neurology Alzheimer's disease adiponectin causality Mendelian randomization risk |
| title | Causal association between adiponectin and the risk of Alzheimer's disease: A Mendelian randomization study |
| title_full | Causal association between adiponectin and the risk of Alzheimer's disease: A Mendelian randomization study |
| title_fullStr | Causal association between adiponectin and the risk of Alzheimer's disease: A Mendelian randomization study |
| title_full_unstemmed | Causal association between adiponectin and the risk of Alzheimer's disease: A Mendelian randomization study |
| title_short | Causal association between adiponectin and the risk of Alzheimer's disease: A Mendelian randomization study |
| title_sort | causal association between adiponectin and the risk of alzheimer s disease a mendelian randomization study |
| topic | Alzheimer's disease adiponectin causality Mendelian randomization risk |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.1038975/full |
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