R-spondin 3 deletion induces Erk phosphorylation to enhance Wnt signaling and promote bone formation in the appendicular skeleton

R-spondin 3 deletion induces Erk phosphorylation to enhance Wnt signaling and promote bone formation in the appendicular skeleton

Activation of Wnt signaling leads to high bone density. The R-spondin family of four secreted glycoproteins (Rspo1-4) amplifies Wnt signaling. In humans, RSPO3 variants are strongly associated with bone density. Here, we investigated the role of Rspo3 in skeletal homeostasis in mice. Using a compreh...

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Bibliographic Details
Main Authors: Kenichi Nagano, Kei Yamana, Hiroaki Saito, Riku Kiviranta, Ana Clara Pedroni, Dhairya Raval, Christof Niehrs, Francesca Gori, Roland Baron
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-11-01
Series:eLife
Subjects:
R-spondin
skeletal homeostasis
Erk signaling
Wnt signaling
Online Access:https://elifesciences.org/articles/84171

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