Synthesis and pharmacological evaluation of a new 2-azabicyclo[3.3.0]octane derivative
As part of a research program aiming at the design, synthesis and pharmacological evaluation of a novel lead-candidates of neuroactive compounds, we describe herein the synthesis and the central profile of a new nebracetam analog having a 2-aza-bicyclo[3.3.0]octane system. The new derivative, design...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Química
2001-01-01
|
| Series: | Journal of the Brazilian Chemical Society |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532001000300013 |
| _version_ | 1819315716727242752 |
|---|---|
| author | Peçanha Emerson P. Fraga Carlos A. M. Barreiro Eliezer J. Braga Maria F. M. Pereira Edna F. R. Albuquerque Edson X. |
| author_facet | Peçanha Emerson P. Fraga Carlos A. M. Barreiro Eliezer J. Braga Maria F. M. Pereira Edna F. R. Albuquerque Edson X. |
| author_sort | Peçanha Emerson P. |
| collection | DOAJ |
| description | As part of a research program aiming at the design, synthesis and pharmacological evaluation of a novel lead-candidates of neuroactive compounds, we describe herein the synthesis and the central profile of a new nebracetam analog having a 2-aza-bicyclo[3.3.0]octane system. The new derivative, designed on the basis of the conformational restriction concept, was synthesized in good yields exploring a diastereoselective reductive-amination and cyclization one-pot sequence. The pharmacological profile of this new compound, investigated by using path-clamp techniques on neurons of the CNS, indicated no effects on these cells. |
| first_indexed | 2024-12-24T10:04:32Z |
| format | Article |
| id | doaj.art-96523a1a36cd4a289e92588a78a7f05a |
| institution | Directory Open Access Journal |
| issn | 0103-5053 |
| language | English |
| last_indexed | 2024-12-24T10:04:32Z |
| publishDate | 2001-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Journal of the Brazilian Chemical Society |
| spelling | doaj.art-96523a1a36cd4a289e92588a78a7f05a2022-12-21T17:00:53ZengSociedade Brasileira de QuímicaJournal of the Brazilian Chemical Society0103-50532001-01-01123408412Synthesis and pharmacological evaluation of a new 2-azabicyclo[3.3.0]octane derivativePeçanha Emerson P.Fraga Carlos A. M.Barreiro Eliezer J.Braga Maria F. M.Pereira Edna F. R.Albuquerque Edson X.As part of a research program aiming at the design, synthesis and pharmacological evaluation of a novel lead-candidates of neuroactive compounds, we describe herein the synthesis and the central profile of a new nebracetam analog having a 2-aza-bicyclo[3.3.0]octane system. The new derivative, designed on the basis of the conformational restriction concept, was synthesized in good yields exploring a diastereoselective reductive-amination and cyclization one-pot sequence. The pharmacological profile of this new compound, investigated by using path-clamp techniques on neurons of the CNS, indicated no effects on these cells.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-505320010003000132-azabicyclo[3.3.0]octane derivativesdiastereoselective reductive-amination/cyclization one-pot processnebracetam analog |
| spellingShingle | Peçanha Emerson P. Fraga Carlos A. M. Barreiro Eliezer J. Braga Maria F. M. Pereira Edna F. R. Albuquerque Edson X. Synthesis and pharmacological evaluation of a new 2-azabicyclo[3.3.0]octane derivative Journal of the Brazilian Chemical Society 2-azabicyclo[3.3.0]octane derivatives diastereoselective reductive-amination/cyclization one-pot process nebracetam analog |
| title | Synthesis and pharmacological evaluation of a new 2-azabicyclo[3.3.0]octane derivative |
| title_full | Synthesis and pharmacological evaluation of a new 2-azabicyclo[3.3.0]octane derivative |
| title_fullStr | Synthesis and pharmacological evaluation of a new 2-azabicyclo[3.3.0]octane derivative |
| title_full_unstemmed | Synthesis and pharmacological evaluation of a new 2-azabicyclo[3.3.0]octane derivative |
| title_short | Synthesis and pharmacological evaluation of a new 2-azabicyclo[3.3.0]octane derivative |
| title_sort | synthesis and pharmacological evaluation of a new 2 azabicyclo 3 3 0 octane derivative |
| topic | 2-azabicyclo[3.3.0]octane derivatives diastereoselective reductive-amination/cyclization one-pot process nebracetam analog |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532001000300013 |
| work_keys_str_mv | AT pecanhaemersonp synthesisandpharmacologicalevaluationofanew2azabicyclo330octanederivative AT fragacarlosam synthesisandpharmacologicalevaluationofanew2azabicyclo330octanederivative AT barreiroeliezerj synthesisandpharmacologicalevaluationofanew2azabicyclo330octanederivative AT bragamariafm synthesisandpharmacologicalevaluationofanew2azabicyclo330octanederivative AT pereiraednafr synthesisandpharmacologicalevaluationofanew2azabicyclo330octanederivative AT albuquerqueedsonx synthesisandpharmacologicalevaluationofanew2azabicyclo330octanederivative |