Cross-reactive Dengue virus-specific CD8+ T cells protect against Zika virus during pregnancy
Heterologous immunity can confer protection between related viruses. Here the authors show that prior exposure to Dengue virus can protect against subsequent infection with Zika virus in the context of pregnancy, and crucially can prevent demise of the fetus in murine models of infection.
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05458-0 |
| _version_ | 1818720921996754944 |
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| author | Jose Angel Regla-Nava Annie Elong Ngono Karla M. Viramontes Anh-Thy Huynh Ying-Ting Wang Anh-Viet T. Nguyen Rebecca Salgado Anila Mamidi Kenneth Kim Michael S. Diamond Sujan Shresta |
| author_facet | Jose Angel Regla-Nava Annie Elong Ngono Karla M. Viramontes Anh-Thy Huynh Ying-Ting Wang Anh-Viet T. Nguyen Rebecca Salgado Anila Mamidi Kenneth Kim Michael S. Diamond Sujan Shresta |
| author_sort | Jose Angel Regla-Nava |
| collection | DOAJ |
| description | Heterologous immunity can confer protection between related viruses. Here the authors show that prior exposure to Dengue virus can protect against subsequent infection with Zika virus in the context of pregnancy, and crucially can prevent demise of the fetus in murine models of infection. |
| first_indexed | 2024-12-17T20:30:32Z |
| format | Article |
| id | doaj.art-965298bef2f549858fe3ead0468da783 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T20:30:32Z |
| publishDate | 2018-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-965298bef2f549858fe3ead0468da7832022-12-21T21:33:36ZengNature PortfolioNature Communications2041-17232018-08-019111410.1038/s41467-018-05458-0Cross-reactive Dengue virus-specific CD8+ T cells protect against Zika virus during pregnancyJose Angel Regla-Nava0Annie Elong Ngono1Karla M. Viramontes2Anh-Thy Huynh3Ying-Ting Wang4Anh-Viet T. Nguyen5Rebecca Salgado6Anila Mamidi7Kenneth Kim8Michael S. Diamond9Sujan Shresta10Division of Inflammation Biology, La Jolla Institute for Allergy & ImmunologyDivision of Inflammation Biology, La Jolla Institute for Allergy & ImmunologyDivision of Inflammation Biology, La Jolla Institute for Allergy & ImmunologyDivision of Inflammation Biology, La Jolla Institute for Allergy & ImmunologyDivision of Inflammation Biology, La Jolla Institute for Allergy & ImmunologyDivision of Inflammation Biology, La Jolla Institute for Allergy & ImmunologyDivision of Inflammation Biology, La Jolla Institute for Allergy & ImmunologyDivision of Inflammation Biology, La Jolla Institute for Allergy & ImmunologyDivision of Inflammation Biology, La Jolla Institute for Allergy & ImmunologyDepartment of Medicine, Molecular Microbiology, Pathology, and Immunology, Center for Human Immunology and Immunotherapy Programs, Washington University School of MedicineDivision of Inflammation Biology, La Jolla Institute for Allergy & ImmunologyHeterologous immunity can confer protection between related viruses. Here the authors show that prior exposure to Dengue virus can protect against subsequent infection with Zika virus in the context of pregnancy, and crucially can prevent demise of the fetus in murine models of infection.https://doi.org/10.1038/s41467-018-05458-0 |
| spellingShingle | Jose Angel Regla-Nava Annie Elong Ngono Karla M. Viramontes Anh-Thy Huynh Ying-Ting Wang Anh-Viet T. Nguyen Rebecca Salgado Anila Mamidi Kenneth Kim Michael S. Diamond Sujan Shresta Cross-reactive Dengue virus-specific CD8+ T cells protect against Zika virus during pregnancy Nature Communications |
| title | Cross-reactive Dengue virus-specific CD8+ T cells protect against Zika virus during pregnancy |
| title_full | Cross-reactive Dengue virus-specific CD8+ T cells protect against Zika virus during pregnancy |
| title_fullStr | Cross-reactive Dengue virus-specific CD8+ T cells protect against Zika virus during pregnancy |
| title_full_unstemmed | Cross-reactive Dengue virus-specific CD8+ T cells protect against Zika virus during pregnancy |
| title_short | Cross-reactive Dengue virus-specific CD8+ T cells protect against Zika virus during pregnancy |
| title_sort | cross reactive dengue virus specific cd8 t cells protect against zika virus during pregnancy |
| url | https://doi.org/10.1038/s41467-018-05458-0 |
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