Possible side effects of ChAdOx1 nCov-19 vaccine in patients with sickle cell disease
Vaccines against acute respiratory syndrome Coronavirus 2(SARS-CoV2) are critical weapons to control the spread of the deadly Coronavirus 2019(COVId-19) virus worldwide. Although these vaccines are generally safe, their widespread use has produced reports of rare complications, including vaccine-ind...
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| Format: | Article |
| Language: | English |
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Mattioli1885
2021-09-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Subjects: | |
| Online Access: | http://mjhid.org/index.php/mjhid/article/view/4708 |
| _version_ | 1819281916491202560 |
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| author | Salam Alkindi Refaat Abdullah Elsadek Anil V Pathare |
| author_facet | Salam Alkindi Refaat Abdullah Elsadek Anil V Pathare |
| author_sort | Salam Alkindi |
| collection | DOAJ |
| description | Vaccines against acute respiratory syndrome Coronavirus 2(SARS-CoV2) are critical weapons to control the spread of the deadly Coronavirus 2019(COVId-19) virus worldwide. Although these vaccines are generally safe, their widespread use has produced reports of rare complications, including vaccine-induced immune thrombotic thrombocytopenia (VIITT), particularly in connection with ChAdOx1 nCov-19. We have identified three cases of sickle cell disease (SCD) experiencing a severe vaso-occlusive crisis (VOC) shortly after the vaccine. Despite being stable for a long time, they had fever with tachycardia, along with a significant rise in WBC, liver enzymes, particularly alkaline phosphate, with a remarkable drop in hemoglobin, and platelets and one of them probably had fatal TTP like syndrome. Given these findings, physicians and patients should exercise caution when taking this type of vaccine and be aware of these safety concerns. |
| first_indexed | 2024-12-24T01:07:18Z |
| format | Article |
| id | doaj.art-9652ed4bd21045f4b7f6702169d4ba0d |
| institution | Directory Open Access Journal |
| issn | 2035-3006 |
| language | English |
| last_indexed | 2024-12-24T01:07:18Z |
| publishDate | 2021-09-01 |
| publisher | Mattioli1885 |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj.art-9652ed4bd21045f4b7f6702169d4ba0d2022-12-21T17:23:09ZengMattioli1885Mediterranean Journal of Hematology and Infectious Diseases2035-30062021-09-0113110.4084/MJHID.2021.059Possible side effects of ChAdOx1 nCov-19 vaccine in patients with sickle cell diseaseSalam Alkindi0Refaat Abdullah Elsadek Anil V Pathare Prof. Salam Alkindi, MD, BA, MB, BCh, BAO, MSc, DME, FRCP Consultant Haematologist , Department of Haematology,College of Medicine and Health Sciences,Sultan Qaboos University,P. O. Box 35,Muscat 123,Sultanate of Oman.Phone:+96824144736.Fax: +96824413419.E-mail:sskindi@yahoo.comVaccines against acute respiratory syndrome Coronavirus 2(SARS-CoV2) are critical weapons to control the spread of the deadly Coronavirus 2019(COVId-19) virus worldwide. Although these vaccines are generally safe, their widespread use has produced reports of rare complications, including vaccine-induced immune thrombotic thrombocytopenia (VIITT), particularly in connection with ChAdOx1 nCov-19. We have identified three cases of sickle cell disease (SCD) experiencing a severe vaso-occlusive crisis (VOC) shortly after the vaccine. Despite being stable for a long time, they had fever with tachycardia, along with a significant rise in WBC, liver enzymes, particularly alkaline phosphate, with a remarkable drop in hemoglobin, and platelets and one of them probably had fatal TTP like syndrome. Given these findings, physicians and patients should exercise caution when taking this type of vaccine and be aware of these safety concerns.http://mjhid.org/index.php/mjhid/article/view/4708SARS-CoV2, ChAdOx1 nCov-19 vaccine, sickle cell disease, Vaso-occlusive crisis, vaccine induced immune thrombotic thrombocytopenia |
| spellingShingle | Salam Alkindi Refaat Abdullah Elsadek Anil V Pathare Possible side effects of ChAdOx1 nCov-19 vaccine in patients with sickle cell disease Mediterranean Journal of Hematology and Infectious Diseases SARS-CoV2, ChAdOx1 nCov-19 vaccine, sickle cell disease, Vaso-occlusive crisis, vaccine induced immune thrombotic thrombocytopenia |
| title | Possible side effects of ChAdOx1 nCov-19 vaccine in patients with sickle cell disease |
| title_full | Possible side effects of ChAdOx1 nCov-19 vaccine in patients with sickle cell disease |
| title_fullStr | Possible side effects of ChAdOx1 nCov-19 vaccine in patients with sickle cell disease |
| title_full_unstemmed | Possible side effects of ChAdOx1 nCov-19 vaccine in patients with sickle cell disease |
| title_short | Possible side effects of ChAdOx1 nCov-19 vaccine in patients with sickle cell disease |
| title_sort | possible side effects of chadox1 ncov 19 vaccine in patients with sickle cell disease |
| topic | SARS-CoV2, ChAdOx1 nCov-19 vaccine, sickle cell disease, Vaso-occlusive crisis, vaccine induced immune thrombotic thrombocytopenia |
| url | http://mjhid.org/index.php/mjhid/article/view/4708 |
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