Mechanics of tissue competition: interfaces stabilize coexistence
Mechanical forces influence the dynamics of growing tissues. Computer simulations are employed to study the importance of interfacial effects in tissue competition. It was speculated previously that mechanical pressure determines the competition, where the determining quantity is the homeostatic pre...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IOP Publishing
2019-01-01
|
| Series: | New Journal of Physics |
| Subjects: | |
| Online Access: | https://doi.org/10.1088/1367-2630/ab2475 |
| _version_ | 1797750087923793920 |
|---|---|
| author | Nirmalendu Ganai Tobias Büscher Gerhard Gompper Jens Elgeti |
| author_facet | Nirmalendu Ganai Tobias Büscher Gerhard Gompper Jens Elgeti |
| author_sort | Nirmalendu Ganai |
| collection | DOAJ |
| description | Mechanical forces influence the dynamics of growing tissues. Computer simulations are employed to study the importance of interfacial effects in tissue competition. It was speculated previously that mechanical pressure determines the competition, where the determining quantity is the homeostatic pressure-the pressure where division and apoptosis balance; the tissue with the higher homeostatic pressure overwhelms the other. In contrast, we find that a weaker tissue can persist in stable coexistence with a stronger tissue, if adhesion between them is small enough. An analytic continuum description can quantitatively describe the underlying mechanism and reproduce the resulting pressures and cell-number fractions. Furthermore, simulations reveal a variety of coexisting structures, ranging from spherical inclusions to a bicontinuous state. |
| first_indexed | 2024-03-12T16:28:37Z |
| format | Article |
| id | doaj.art-96537105ff2e41cca5e8423427fa2bdb |
| institution | Directory Open Access Journal |
| issn | 1367-2630 |
| language | English |
| last_indexed | 2024-03-12T16:28:37Z |
| publishDate | 2019-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | New Journal of Physics |
| spelling | doaj.art-96537105ff2e41cca5e8423427fa2bdb2023-08-08T15:37:59ZengIOP PublishingNew Journal of Physics1367-26302019-01-0121606301710.1088/1367-2630/ab2475Mechanics of tissue competition: interfaces stabilize coexistenceNirmalendu Ganai0Tobias Büscher1https://orcid.org/0000-0002-5009-1479Gerhard Gompper2https://orcid.org/0000-0002-8904-0986Jens Elgeti3https://orcid.org/0000-0001-7300-0923Theoretical Soft Matter and Biophysics, Institute of Complex Systems, Forschungszentrum Jülich and JARA, D-52425 Jülich, Germany; Department of Physics, Nabadwip Vidyasagar College, Nabadwip, Nadia 741302, IndiaTheoretical Soft Matter and Biophysics, Institute of Complex Systems, Forschungszentrum Jülich and JARA, D-52425 Jülich, GermanyTheoretical Soft Matter and Biophysics, Institute of Complex Systems, Forschungszentrum Jülich and JARA, D-52425 Jülich, GermanyTheoretical Soft Matter and Biophysics, Institute of Complex Systems, Forschungszentrum Jülich and JARA, D-52425 Jülich, GermanyMechanical forces influence the dynamics of growing tissues. Computer simulations are employed to study the importance of interfacial effects in tissue competition. It was speculated previously that mechanical pressure determines the competition, where the determining quantity is the homeostatic pressure-the pressure where division and apoptosis balance; the tissue with the higher homeostatic pressure overwhelms the other. In contrast, we find that a weaker tissue can persist in stable coexistence with a stronger tissue, if adhesion between them is small enough. An analytic continuum description can quantitatively describe the underlying mechanism and reproduce the resulting pressures and cell-number fractions. Furthermore, simulations reveal a variety of coexisting structures, ranging from spherical inclusions to a bicontinuous state.https://doi.org/10.1088/1367-2630/ab2475tissue competitiontissue growthhomeostatic pressureparticle-based simulations |
| spellingShingle | Nirmalendu Ganai Tobias Büscher Gerhard Gompper Jens Elgeti Mechanics of tissue competition: interfaces stabilize coexistence New Journal of Physics tissue competition tissue growth homeostatic pressure particle-based simulations |
| title | Mechanics of tissue competition: interfaces stabilize coexistence |
| title_full | Mechanics of tissue competition: interfaces stabilize coexistence |
| title_fullStr | Mechanics of tissue competition: interfaces stabilize coexistence |
| title_full_unstemmed | Mechanics of tissue competition: interfaces stabilize coexistence |
| title_short | Mechanics of tissue competition: interfaces stabilize coexistence |
| title_sort | mechanics of tissue competition interfaces stabilize coexistence |
| topic | tissue competition tissue growth homeostatic pressure particle-based simulations |
| url | https://doi.org/10.1088/1367-2630/ab2475 |
| work_keys_str_mv | AT nirmalenduganai mechanicsoftissuecompetitioninterfacesstabilizecoexistence AT tobiasbuscher mechanicsoftissuecompetitioninterfacesstabilizecoexistence AT gerhardgompper mechanicsoftissuecompetitioninterfacesstabilizecoexistence AT jenselgeti mechanicsoftissuecompetitioninterfacesstabilizecoexistence |