Vitamin D in Treatment-Resistant Carpal Tunnel Syndrome Patients with Hypovitaminosis D
Introduction: Vitamin D significantly effects health. Extraskeletal effects of vitamin D play an important role. Aim: To study effect of treatment with vitamin D in intractable Carpal Tunnel Syndrome (CTS) patients with hypovitaminosis D referred to the Physical Medicine and Rehabilitation Clinics o...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2018-07-01
|
| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/11828/26417_CE(RA1)_F(AP)_PF1(SH_OM)_PFA(OM)_PN(SS)_PF2(SJ_AP).pdf |
| _version_ | 1818202994821300224 |
|---|---|
| author | Marzieh Mohtashamkia Sharareh Roshanzamir Seyed Mohammad Saghanezhad |
| author_facet | Marzieh Mohtashamkia Sharareh Roshanzamir Seyed Mohammad Saghanezhad |
| author_sort | Marzieh Mohtashamkia |
| collection | DOAJ |
| description | Introduction: Vitamin D significantly effects health. Extraskeletal effects of vitamin D play an important role. Aim: To study effect of treatment with vitamin D in intractable Carpal Tunnel Syndrome (CTS) patients with hypovitaminosis D referred to the Physical Medicine and Rehabilitation Clinics of Shiraz University of Medical Sciences in 2015. Materials and Methods: This interventional study investigated 50 intractable CTS patients by electrodiagnostic study and physical examinations who did not respond to standard management of CTS for six weeks with concomitant hypovitaminosis D 25(OH). A dose of 50000 IU vitamin D3 was given orally per week for 12 weeks. Re-evaluation of patients by electrodiagnostic study was done within one week of taking the last dose. A questionnaire was designed to collect data including age, gender, Body Mass Index (BMI), past medical history, drug history, boston score before and after treatment with vitamin D, serum level of vitamin D before treatment. SPSS version 20.0 was used to analyze data. Results: The mean Boston symptom score prior to the treatment was (3.45±0.90) which reduced to (2.04±0.71) after treatment. The mean Boston function score before treatment was (3.41±0.85) which reduced to (2.08±0.82) after treatment. Mean Slat values before treatment was (4.5±0.57) which reduced to (3.89±0.53) after treatment. Mean Mlat values before treatment was (5.03±0.49) which reduced to (4.66±0.44) after treatment. Mean NCV values before treatment was (27.02±4.64) which reduced to (32.58±4.54) after treatment. There was a significant difference between Boston scores, Slat, Mlat and NCV values before and after treatment with vitamin D (p-value=0.0001). Conclusion: It is concluded that treatment with vitamin D improves clinical and electrodiagnostic conditions of treatmentresistant CTS patients with hypovitaminosis D. |
| first_indexed | 2024-12-12T03:18:18Z |
| format | Article |
| id | doaj.art-96545d2d0b3545bd96c50613fe95af2c |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-12T03:18:18Z |
| publishDate | 2018-07-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-96545d2d0b3545bd96c50613fe95af2c2022-12-22T00:40:15ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2018-07-01127LC23LC2610.7860/JCDR/2018/26417.11828Vitamin D in Treatment-Resistant Carpal Tunnel Syndrome Patients with Hypovitaminosis DMarzieh Mohtashamkia0Sharareh Roshanzamir1Seyed Mohammad Saghanezhad2Student, Student Research Committee, Department of Physical Medicine and Rehabilitation, Shiraz University of Medical Sciences, Shiraz, Iran.Assistant Professor, Student Research Committee, Department of Physical Medicine and Rehabilitation, Shiraz University of Medical Sciences, Shiraz, Iran.Student, Student Research Committee, Department of Physical Medicine and Rehabilitation, Shiraz University of Medical Sciences, Shiraz, Iran.Introduction: Vitamin D significantly effects health. Extraskeletal effects of vitamin D play an important role. Aim: To study effect of treatment with vitamin D in intractable Carpal Tunnel Syndrome (CTS) patients with hypovitaminosis D referred to the Physical Medicine and Rehabilitation Clinics of Shiraz University of Medical Sciences in 2015. Materials and Methods: This interventional study investigated 50 intractable CTS patients by electrodiagnostic study and physical examinations who did not respond to standard management of CTS for six weeks with concomitant hypovitaminosis D 25(OH). A dose of 50000 IU vitamin D3 was given orally per week for 12 weeks. Re-evaluation of patients by electrodiagnostic study was done within one week of taking the last dose. A questionnaire was designed to collect data including age, gender, Body Mass Index (BMI), past medical history, drug history, boston score before and after treatment with vitamin D, serum level of vitamin D before treatment. SPSS version 20.0 was used to analyze data. Results: The mean Boston symptom score prior to the treatment was (3.45±0.90) which reduced to (2.04±0.71) after treatment. The mean Boston function score before treatment was (3.41±0.85) which reduced to (2.08±0.82) after treatment. Mean Slat values before treatment was (4.5±0.57) which reduced to (3.89±0.53) after treatment. Mean Mlat values before treatment was (5.03±0.49) which reduced to (4.66±0.44) after treatment. Mean NCV values before treatment was (27.02±4.64) which reduced to (32.58±4.54) after treatment. There was a significant difference between Boston scores, Slat, Mlat and NCV values before and after treatment with vitamin D (p-value=0.0001). Conclusion: It is concluded that treatment with vitamin D improves clinical and electrodiagnostic conditions of treatmentresistant CTS patients with hypovitaminosis D.https://jcdr.net/articles/PDF/11828/26417_CE(RA1)_F(AP)_PF1(SH_OM)_PFA(OM)_PN(SS)_PF2(SJ_AP).pdfboston scaleelectrodiagnostic studyperipheral neuropathy |
| spellingShingle | Marzieh Mohtashamkia Sharareh Roshanzamir Seyed Mohammad Saghanezhad Vitamin D in Treatment-Resistant Carpal Tunnel Syndrome Patients with Hypovitaminosis D Journal of Clinical and Diagnostic Research boston scale electrodiagnostic study peripheral neuropathy |
| title | Vitamin D in Treatment-Resistant Carpal Tunnel Syndrome Patients with Hypovitaminosis D |
| title_full | Vitamin D in Treatment-Resistant Carpal Tunnel Syndrome Patients with Hypovitaminosis D |
| title_fullStr | Vitamin D in Treatment-Resistant Carpal Tunnel Syndrome Patients with Hypovitaminosis D |
| title_full_unstemmed | Vitamin D in Treatment-Resistant Carpal Tunnel Syndrome Patients with Hypovitaminosis D |
| title_short | Vitamin D in Treatment-Resistant Carpal Tunnel Syndrome Patients with Hypovitaminosis D |
| title_sort | vitamin d in treatment resistant carpal tunnel syndrome patients with hypovitaminosis d |
| topic | boston scale electrodiagnostic study peripheral neuropathy |
| url | https://jcdr.net/articles/PDF/11828/26417_CE(RA1)_F(AP)_PF1(SH_OM)_PFA(OM)_PN(SS)_PF2(SJ_AP).pdf |
| work_keys_str_mv | AT marziehmohtashamkia vitamindintreatmentresistantcarpaltunnelsyndromepatientswithhypovitaminosisd AT shararehroshanzamir vitamindintreatmentresistantcarpaltunnelsyndromepatientswithhypovitaminosisd AT seyedmohammadsaghanezhad vitamindintreatmentresistantcarpaltunnelsyndromepatientswithhypovitaminosisd |