Elbasvir/Grazoprevir, an Alternative in Antiviral Hepatitis C Therapy in Patients under Amiodarone Treatment
A sofosbuvir/ledipasvir combination is part of a first-line treatment of hepatitis C. However, in patients concurrently treated with amiodarone, cardiac side effects have been described, resulting in an official warning in 2015 by the American Food and Drug Administration and the European Medicines...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2018-02-01
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| Series: | Case Reports in Gastroenterology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/486951 |
| _version_ | 1811278380617695232 |
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| author | Lina Weiss Kerstin Wustmann Mariam Semmo Markus Schwerzmann Nasser Semmo |
| author_facet | Lina Weiss Kerstin Wustmann Mariam Semmo Markus Schwerzmann Nasser Semmo |
| author_sort | Lina Weiss |
| collection | DOAJ |
| description | A sofosbuvir/ledipasvir combination is part of a first-line treatment of hepatitis C. However, in patients concurrently treated with amiodarone, cardiac side effects have been described, resulting in an official warning in 2015 by the American Food and Drug Administration and the European Medicines Agency when combining those substances. This deprived numerous hepatitis C patients with concurrent cardiovascular problems of receiving this highly effective treatment. Here we present a treatment alternative with an elbasvir/grazoprevir regimen, based on our successful treatment of a patient under concurrent amiodarone therapy. Our observations indicate that patients treated with amiodarone can finally benefit from effective antiviral therapy. |
| first_indexed | 2024-04-13T00:34:38Z |
| format | Article |
| id | doaj.art-9655a8732e754ce59ca72cbd19e2186d |
| institution | Directory Open Access Journal |
| issn | 1662-0631 |
| language | English |
| last_indexed | 2024-04-13T00:34:38Z |
| publishDate | 2018-02-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Gastroenterology |
| spelling | doaj.art-9655a8732e754ce59ca72cbd19e2186d2022-12-22T03:10:22ZengKarger PublishersCase Reports in Gastroenterology1662-06312018-02-01121929810.1159/000486951486951Elbasvir/Grazoprevir, an Alternative in Antiviral Hepatitis C Therapy in Patients under Amiodarone TreatmentLina WeissKerstin WustmannMariam SemmoMarkus SchwerzmannNasser SemmoA sofosbuvir/ledipasvir combination is part of a first-line treatment of hepatitis C. However, in patients concurrently treated with amiodarone, cardiac side effects have been described, resulting in an official warning in 2015 by the American Food and Drug Administration and the European Medicines Agency when combining those substances. This deprived numerous hepatitis C patients with concurrent cardiovascular problems of receiving this highly effective treatment. Here we present a treatment alternative with an elbasvir/grazoprevir regimen, based on our successful treatment of a patient under concurrent amiodarone therapy. Our observations indicate that patients treated with amiodarone can finally benefit from effective antiviral therapy.https://www.karger.com/Article/FullText/486951Drug interactionsAntiviral agentsHepatitis CAmiodarone |
| spellingShingle | Lina Weiss Kerstin Wustmann Mariam Semmo Markus Schwerzmann Nasser Semmo Elbasvir/Grazoprevir, an Alternative in Antiviral Hepatitis C Therapy in Patients under Amiodarone Treatment Case Reports in Gastroenterology Drug interactions Antiviral agents Hepatitis C Amiodarone |
| title | Elbasvir/Grazoprevir, an Alternative in Antiviral Hepatitis C Therapy in Patients under Amiodarone Treatment |
| title_full | Elbasvir/Grazoprevir, an Alternative in Antiviral Hepatitis C Therapy in Patients under Amiodarone Treatment |
| title_fullStr | Elbasvir/Grazoprevir, an Alternative in Antiviral Hepatitis C Therapy in Patients under Amiodarone Treatment |
| title_full_unstemmed | Elbasvir/Grazoprevir, an Alternative in Antiviral Hepatitis C Therapy in Patients under Amiodarone Treatment |
| title_short | Elbasvir/Grazoprevir, an Alternative in Antiviral Hepatitis C Therapy in Patients under Amiodarone Treatment |
| title_sort | elbasvir grazoprevir an alternative in antiviral hepatitis c therapy in patients under amiodarone treatment |
| topic | Drug interactions Antiviral agents Hepatitis C Amiodarone |
| url | https://www.karger.com/Article/FullText/486951 |
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