Immediate Changes of Glucose Metabolism After Gastretomy for Early Gastric Cancer in Patients with Type 2 Diabetes
Objectives It is well known that type 2 diabetes (T2DM) is dramatically improved after bariatric surgery, although the mechanisms have not been clearly identified. The skill required for gastric surgery for gastric cancer is very similar to that needed in bariatric surgery. In this study, we evaluat...
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| Format: | Article |
| Language: | English |
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Kosin University College of Medicine
2021-12-01
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| Series: | Kosin Medical Journal |
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| Online Access: | http://www.kosinmedj.org/upload/pdf/ksmc036-01-03.pdf |
| _version_ | 1797991497959735296 |
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| author | Ki Hyun Kim Yoon Hong Kim Kyung Won Seo Ki Young Yoon Yeon Myeong Shin Young Sik Choi Bu Kyung Kim |
| author_facet | Ki Hyun Kim Yoon Hong Kim Kyung Won Seo Ki Young Yoon Yeon Myeong Shin Young Sik Choi Bu Kyung Kim |
| author_sort | Ki Hyun Kim |
| collection | DOAJ |
| description | Objectives It is well known that type 2 diabetes (T2DM) is dramatically improved after bariatric surgery, although the mechanisms have not been clearly identified. The skill required for gastric surgery for gastric cancer is very similar to that needed in bariatric surgery. In this study, we evaluated the immediate improvement of T2DM after gastrectomy for gastric cancer. Methods A total of nine patients who were diagnosed with early gastric cancer (EGC) and already had T2DM underwent a 75 g oral glucose tolerance test (OGTT) before surgery and within two weeks after gastrectomy. Glucose, insulin, and c-peptide were measured before, and 30 and 60 minutes after ingesting 75 g of glucose. From these trials, we calculated the HOMA-IR, insulinogenic index, Matsuda index, and area under the curve (AUC). Results The mean age of participants was 57.23 ± 11.08 years and eight of them were men. HOMA-IR (4.2 vs. 2.3, P = 0.012) levels were decreased after surgery. There were no significant differences of insulinogenic index, fasting blood sugar before and after surgery. The Matsuda index (3.3 vs. 8.3, P = 0.002) was significantly increased and AUC (512.9 vs. 388.7 mg-hr/dL, P > 0.001) upon 75 g OGTT was significantly decreased after surgery. Conclusions Insulin sensitivity was immediately improved after gastrectomy for early gastric cancer in patients with T2DM. |
| first_indexed | 2024-04-11T08:52:07Z |
| format | Article |
| id | doaj.art-9656403ed387463fa6797d8e65420602 |
| institution | Directory Open Access Journal |
| issn | 2005-9531 2586-7024 |
| language | English |
| last_indexed | 2024-04-11T08:52:07Z |
| publishDate | 2021-12-01 |
| publisher | Kosin University College of Medicine |
| record_format | Article |
| series | Kosin Medical Journal |
| spelling | doaj.art-9656403ed387463fa6797d8e654206022022-12-22T04:33:27ZengKosin University College of MedicineKosin Medical Journal2005-95312586-70242021-12-01361253310.7180/kmj.2021.36.1.25235Immediate Changes of Glucose Metabolism After Gastretomy for Early Gastric Cancer in Patients with Type 2 DiabetesKi Hyun Kim0Yoon Hong Kim1Kyung Won Seo2Ki Young Yoon3Yeon Myeong Shin4Young Sik Choi5Bu Kyung Kim6 Department of Surgery, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Korea Department of Surgery, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Korea Department of Surgery, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Korea Department of Surgery, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Korea Department of Surgery, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, KoreaObjectives It is well known that type 2 diabetes (T2DM) is dramatically improved after bariatric surgery, although the mechanisms have not been clearly identified. The skill required for gastric surgery for gastric cancer is very similar to that needed in bariatric surgery. In this study, we evaluated the immediate improvement of T2DM after gastrectomy for gastric cancer. Methods A total of nine patients who were diagnosed with early gastric cancer (EGC) and already had T2DM underwent a 75 g oral glucose tolerance test (OGTT) before surgery and within two weeks after gastrectomy. Glucose, insulin, and c-peptide were measured before, and 30 and 60 minutes after ingesting 75 g of glucose. From these trials, we calculated the HOMA-IR, insulinogenic index, Matsuda index, and area under the curve (AUC). Results The mean age of participants was 57.23 ± 11.08 years and eight of them were men. HOMA-IR (4.2 vs. 2.3, P = 0.012) levels were decreased after surgery. There were no significant differences of insulinogenic index, fasting blood sugar before and after surgery. The Matsuda index (3.3 vs. 8.3, P = 0.002) was significantly increased and AUC (512.9 vs. 388.7 mg-hr/dL, P > 0.001) upon 75 g OGTT was significantly decreased after surgery. Conclusions Insulin sensitivity was immediately improved after gastrectomy for early gastric cancer in patients with T2DM.http://www.kosinmedj.org/upload/pdf/ksmc036-01-03.pdfearly gastric cancerinsulin secretioninsulin sensitivitytype 2 diabetes |
| spellingShingle | Ki Hyun Kim Yoon Hong Kim Kyung Won Seo Ki Young Yoon Yeon Myeong Shin Young Sik Choi Bu Kyung Kim Immediate Changes of Glucose Metabolism After Gastretomy for Early Gastric Cancer in Patients with Type 2 Diabetes Kosin Medical Journal early gastric cancer insulin secretion insulin sensitivity type 2 diabetes |
| title | Immediate Changes of Glucose Metabolism After Gastretomy for Early Gastric Cancer in Patients with Type 2 Diabetes |
| title_full | Immediate Changes of Glucose Metabolism After Gastretomy for Early Gastric Cancer in Patients with Type 2 Diabetes |
| title_fullStr | Immediate Changes of Glucose Metabolism After Gastretomy for Early Gastric Cancer in Patients with Type 2 Diabetes |
| title_full_unstemmed | Immediate Changes of Glucose Metabolism After Gastretomy for Early Gastric Cancer in Patients with Type 2 Diabetes |
| title_short | Immediate Changes of Glucose Metabolism After Gastretomy for Early Gastric Cancer in Patients with Type 2 Diabetes |
| title_sort | immediate changes of glucose metabolism after gastretomy for early gastric cancer in patients with type 2 diabetes |
| topic | early gastric cancer insulin secretion insulin sensitivity type 2 diabetes |
| url | http://www.kosinmedj.org/upload/pdf/ksmc036-01-03.pdf |
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