Genetic variations of the NPC1L1 gene associated with hepatitis C virus (HCV) infection and biochemical characteristics of HCV patients in China
Objectives: About 2% of the world population is infected with hepatitis C virus (HCV), a leading cause of hepatic cirrhosis and hepatocellular carcinoma. The Niemann–Pick C1-like 1 cholesterol absorption receptor (NPC1L1) was recently identified to be an important factor for HCV entry into host cell...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-12-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971216311900 |
| _version_ | 1818481574320013312 |
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| author | A.-Mei Zhang Cheng-Lin Zhang Yuzhu Song Ping Zhao Yue Feng Binghui Wang Zheng Li Li Liu Xueshan Xia |
| author_facet | A.-Mei Zhang Cheng-Lin Zhang Yuzhu Song Ping Zhao Yue Feng Binghui Wang Zheng Li Li Liu Xueshan Xia |
| author_sort | A.-Mei Zhang |
| collection | DOAJ |
| description | Objectives: About 2% of the world population is infected with hepatitis C virus (HCV), a leading cause of hepatic cirrhosis and hepatocellular carcinoma. The Niemann–Pick C1-like 1 cholesterol absorption receptor (NPC1L1) was recently identified to be an important factor for HCV entry into host cells. Whether genetic variations of the NPC1L1 gene are associated with HCV infection is unknown.
Methods: In this study, five single nucleotide polymorphisms (SNPs) of the NPC1L1 gene were analyzed in 261 HCV-infected individuals and 265 general controls from Yunnan Province, China.
Results: No significant differences were identified in genotypes or alleles of the SNPs between the two groups. After constructing haplotypes based on the five SNPs, a significant difference between HCV-infected individuals and general controls was shown for two haplotypes. Haplotype GCCTT appeared to be a protective factor and haplotype GCCCT was a risk factor for HCV-infected individuals. Genotypes of four SNPs correlated with biochemical characteristics of HCV-infected persons. Genotypes of SNPs rs799444 and rs2070607 were correlated with total bilirubin. Genotype TT of rs917098 was a risk factor for the gamma-glutamyltransferase level. Furthermore, HCV-infected individuals carrying genotype GG of rs41279633 showed statistically higher gamma-glutamyltransferase levels than HCV-infected persons with GT and TT.
Conclusion: The results of this study identified the association between genetic susceptibility of the NPC1L1 gene and HCV infection, as well as biochemical characteristics of HCV-infected persons in Yunnan, China. |
| first_indexed | 2024-12-10T11:36:47Z |
| format | Article |
| id | doaj.art-9656957a31d243baae677fa6a14a1cc8 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 1878-3511 |
| language | English |
| last_indexed | 2024-12-10T11:36:47Z |
| publishDate | 2016-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-9656957a31d243baae677fa6a14a1cc82022-12-22T01:50:24ZengElsevierInternational Journal of Infectious Diseases1201-97121878-35112016-12-0153C61110.1016/j.ijid.2016.10.007Genetic variations of the NPC1L1 gene associated with hepatitis C virus (HCV) infection and biochemical characteristics of HCV patients in ChinaA.-Mei Zhang0Cheng-Lin Zhang1Yuzhu Song2Ping Zhao3Yue Feng4Binghui Wang5Zheng Li6Li Liu7Xueshan Xia8Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, ChinaFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, ChinaFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, ChinaDepartment of Microbiology, Shanghai Key Laboratory of Medical Biodefense, Second Military Medical University, Shanghai, ChinaFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, ChinaFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, ChinaDepartment of Clinical Laboratory, The First People's Hospital of Yunnan Province, Yunnan, ChinaFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, ChinaFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, ChinaObjectives: About 2% of the world population is infected with hepatitis C virus (HCV), a leading cause of hepatic cirrhosis and hepatocellular carcinoma. The Niemann–Pick C1-like 1 cholesterol absorption receptor (NPC1L1) was recently identified to be an important factor for HCV entry into host cells. Whether genetic variations of the NPC1L1 gene are associated with HCV infection is unknown. Methods: In this study, five single nucleotide polymorphisms (SNPs) of the NPC1L1 gene were analyzed in 261 HCV-infected individuals and 265 general controls from Yunnan Province, China. Results: No significant differences were identified in genotypes or alleles of the SNPs between the two groups. After constructing haplotypes based on the five SNPs, a significant difference between HCV-infected individuals and general controls was shown for two haplotypes. Haplotype GCCTT appeared to be a protective factor and haplotype GCCCT was a risk factor for HCV-infected individuals. Genotypes of four SNPs correlated with biochemical characteristics of HCV-infected persons. Genotypes of SNPs rs799444 and rs2070607 were correlated with total bilirubin. Genotype TT of rs917098 was a risk factor for the gamma-glutamyltransferase level. Furthermore, HCV-infected individuals carrying genotype GG of rs41279633 showed statistically higher gamma-glutamyltransferase levels than HCV-infected persons with GT and TT. Conclusion: The results of this study identified the association between genetic susceptibility of the NPC1L1 gene and HCV infection, as well as biochemical characteristics of HCV-infected persons in Yunnan, China.http://www.sciencedirect.com/science/article/pii/S1201971216311900HCV infectionNPC1L1 geneSNPsBiochemical characteristics |
| spellingShingle | A.-Mei Zhang Cheng-Lin Zhang Yuzhu Song Ping Zhao Yue Feng Binghui Wang Zheng Li Li Liu Xueshan Xia Genetic variations of the NPC1L1 gene associated with hepatitis C virus (HCV) infection and biochemical characteristics of HCV patients in China International Journal of Infectious Diseases HCV infection NPC1L1 gene SNPs Biochemical characteristics |
| title | Genetic variations of the NPC1L1 gene associated with hepatitis C virus (HCV) infection and biochemical characteristics of HCV patients in China |
| title_full | Genetic variations of the NPC1L1 gene associated with hepatitis C virus (HCV) infection and biochemical characteristics of HCV patients in China |
| title_fullStr | Genetic variations of the NPC1L1 gene associated with hepatitis C virus (HCV) infection and biochemical characteristics of HCV patients in China |
| title_full_unstemmed | Genetic variations of the NPC1L1 gene associated with hepatitis C virus (HCV) infection and biochemical characteristics of HCV patients in China |
| title_short | Genetic variations of the NPC1L1 gene associated with hepatitis C virus (HCV) infection and biochemical characteristics of HCV patients in China |
| title_sort | genetic variations of the npc1l1 gene associated with hepatitis c virus hcv infection and biochemical characteristics of hcv patients in china |
| topic | HCV infection NPC1L1 gene SNPs Biochemical characteristics |
| url | http://www.sciencedirect.com/science/article/pii/S1201971216311900 |
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