Receptor editing constrains development of phosphatidyl choline-specific B cells in VH12-transgenic mice

Receptor editing constrains development of phosphatidyl choline-specific B cells in VH12-transgenic mice

Summary: B1 B cells reactive to phosphatidyl choline (PtC) exhibit restricted immunoglobulin heavy chain (HC) and light chain (LC) combinations, exemplified by VH12/Vκ4/5H. Two checkpoints are thought to focus PtC+ B cell maturation in VH12-transgenic mice (VH12 mice): V-J rearrangements encoding a...

Full description

Bibliographic Details
Main Authors: Alexandra N. Worth, Victoria L. Palmer, N. Max Schabla, Greg A. Perry, Anna N. Fraser-Philbin, Patrick C. Swanson
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472200674X

Similar Items

Similar Items