Are there any new reliable markers to detect renal injury in obese children?
Aim: The aim of this study was to examine the serum and urine levels of kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), osteopontin (OPN), matrix metalloproteinase-9 (MMP-9), and serum Cystatin-C to determine the renal effect of obesity in obese children. Methods...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-10-01
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| Series: | Renal Failure |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/0886022X.2018.1489284 |
| _version_ | 1811223445593128960 |
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| author | Özlem Bostan Gayret Mehmet Taşdemir Meltem Erol Hikmet Tekin Nacaroğlu Oğuzhan Zengi Özgül Yiğit |
| author_facet | Özlem Bostan Gayret Mehmet Taşdemir Meltem Erol Hikmet Tekin Nacaroğlu Oğuzhan Zengi Özgül Yiğit |
| author_sort | Özlem Bostan Gayret |
| collection | DOAJ |
| description | Aim: The aim of this study was to examine the serum and urine levels of kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), osteopontin (OPN), matrix metalloproteinase-9 (MMP-9), and serum Cystatin-C to determine the renal effect of obesity in obese children. Methods: Seventy-two obese and 35 non-obese healthy children were included in this study. Blood pressure (BP) was evaluated with office measurement. Creatinine, cystatin C, lipids, fasting glucose, and insulin levels were measured, and homeostasis model assessment -insulin resistance (HOMA-IR) was calculated. The urine albumin/creatinine ratio was calculated. The serum and urine KIM-1, NGAL, OPN, and MMP-9 levels were measured. Results: Serum cystatin-C, triglyceride, and homeostasis model assessment-insulin resistance (HOMA-IR) index were found to be significantly higher in the obese group (p = .0001), and high-density lipoprotein (HDL) cholesterol was found to be significantly lower (p = .019) in the obese group. No significant differences were found in serum KIM-1, NGAL, OPN or MMP-9 levels between groups (p > .05). No significant differences were found in urine KIM-1 and MMP-9 levels (p > .05), Urine NGAL, and OPN levels were found significantly higher in obese groups (p < .05). Conclusions: According to our results, although serum KIM-1, NGAL, OPN, MMP-9, and urine MMP-9, urine KIM-1 do not appear to be ideal markers to evaluate renal injury in the early period of obesity, the serum levels of cystatin C and urine NGAL, urine OPN can be used as a good marker for assessing the renal effect of obesity which can lead end stage renal disease in pediatric population. |
| first_indexed | 2024-04-12T08:33:06Z |
| format | Article |
| id | doaj.art-96573c1b67ba4a6aaa4e293ffcec350c |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-04-12T08:33:06Z |
| publishDate | 2018-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-96573c1b67ba4a6aaa4e293ffcec350c2022-12-22T03:40:06ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492018-10-0140141642210.1080/0886022X.2018.14892841489284Are there any new reliable markers to detect renal injury in obese children?Özlem Bostan Gayret0Mehmet Taşdemir1Meltem Erol2Hikmet Tekin Nacaroğlu3Oğuzhan Zengi4Özgül Yiğit5Ministry of Health, Bağcılar Training and Research HospitalKoc University HospitalMinistry of Health, Bağcılar Training and Research HospitalMedipol University HospitalMinistry of Health, Bağcılar Training and Research HospitalMinistry of Health, Bağcılar Training and Research HospitalAim: The aim of this study was to examine the serum and urine levels of kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), osteopontin (OPN), matrix metalloproteinase-9 (MMP-9), and serum Cystatin-C to determine the renal effect of obesity in obese children. Methods: Seventy-two obese and 35 non-obese healthy children were included in this study. Blood pressure (BP) was evaluated with office measurement. Creatinine, cystatin C, lipids, fasting glucose, and insulin levels were measured, and homeostasis model assessment -insulin resistance (HOMA-IR) was calculated. The urine albumin/creatinine ratio was calculated. The serum and urine KIM-1, NGAL, OPN, and MMP-9 levels were measured. Results: Serum cystatin-C, triglyceride, and homeostasis model assessment-insulin resistance (HOMA-IR) index were found to be significantly higher in the obese group (p = .0001), and high-density lipoprotein (HDL) cholesterol was found to be significantly lower (p = .019) in the obese group. No significant differences were found in serum KIM-1, NGAL, OPN or MMP-9 levels between groups (p > .05). No significant differences were found in urine KIM-1 and MMP-9 levels (p > .05), Urine NGAL, and OPN levels were found significantly higher in obese groups (p < .05). Conclusions: According to our results, although serum KIM-1, NGAL, OPN, MMP-9, and urine MMP-9, urine KIM-1 do not appear to be ideal markers to evaluate renal injury in the early period of obesity, the serum levels of cystatin C and urine NGAL, urine OPN can be used as a good marker for assessing the renal effect of obesity which can lead end stage renal disease in pediatric population.http://dx.doi.org/10.1080/0886022X.2018.1489284Cystatin CKIM-1NGALOPNMMP-9obesechildren |
| spellingShingle | Özlem Bostan Gayret Mehmet Taşdemir Meltem Erol Hikmet Tekin Nacaroğlu Oğuzhan Zengi Özgül Yiğit Are there any new reliable markers to detect renal injury in obese children? Renal Failure Cystatin C KIM-1 NGAL OPN MMP-9 obese children |
| title | Are there any new reliable markers to detect renal injury in obese children? |
| title_full | Are there any new reliable markers to detect renal injury in obese children? |
| title_fullStr | Are there any new reliable markers to detect renal injury in obese children? |
| title_full_unstemmed | Are there any new reliable markers to detect renal injury in obese children? |
| title_short | Are there any new reliable markers to detect renal injury in obese children? |
| title_sort | are there any new reliable markers to detect renal injury in obese children |
| topic | Cystatin C KIM-1 NGAL OPN MMP-9 obese children |
| url | http://dx.doi.org/10.1080/0886022X.2018.1489284 |
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