Therapeutic Targeting Strategies of Cancer Stem Cells in Gastrointestinal Malignancies
Cancer stem cells (CSCs) are thought to be a distinct population of cells within a tumor mass that are capable of asymmetric division and known to have chemoresistant characteristics. The description and identification of CSC models in cancer growth and recurrence has inspired the design of novel tr...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-03-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2227-9059/7/1/17 |
| _version_ | 1819018230039052288 |
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| author | Mohamad B. Sonbol Daniel H. Ahn Tanios Bekaii-Saab |
| author_facet | Mohamad B. Sonbol Daniel H. Ahn Tanios Bekaii-Saab |
| author_sort | Mohamad B. Sonbol |
| collection | DOAJ |
| description | Cancer stem cells (CSCs) are thought to be a distinct population of cells within a tumor mass that are capable of asymmetric division and known to have chemoresistant characteristics. The description and identification of CSC models in cancer growth and recurrence has inspired the design of novel treatment strategies to overcome treatment resistance by targeting both CSCs and non-CSC tumor cells. Several cellular signaling pathways have been described as playing a role in the induction and maintenance of stemness in CSCs, such as the Wnt/β-catenin, Notch, STAT3, and Hedgehog pathways. In this review, we aim to review some of the ongoing CSC therapeutic targeting strategies in gastrointestinal malignancies. |
| first_indexed | 2024-12-21T03:16:07Z |
| format | Article |
| id | doaj.art-9659511c447149e6b5db5e13ee05ab72 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-12-21T03:16:07Z |
| publishDate | 2019-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-9659511c447149e6b5db5e13ee05ab722022-12-21T19:17:50ZengMDPI AGBiomedicines2227-90592019-03-01711710.3390/biomedicines7010017biomedicines7010017Therapeutic Targeting Strategies of Cancer Stem Cells in Gastrointestinal MalignanciesMohamad B. Sonbol0Daniel H. Ahn1Tanios Bekaii-Saab2Mayo Clinic Cancer Center, Mayo Clinic, Phoenix, AZ 85054, USAMayo Clinic Cancer Center, Mayo Clinic, Phoenix, AZ 85054, USAMayo Clinic Cancer Center, Mayo Clinic, Phoenix, AZ 85054, USACancer stem cells (CSCs) are thought to be a distinct population of cells within a tumor mass that are capable of asymmetric division and known to have chemoresistant characteristics. The description and identification of CSC models in cancer growth and recurrence has inspired the design of novel treatment strategies to overcome treatment resistance by targeting both CSCs and non-CSC tumor cells. Several cellular signaling pathways have been described as playing a role in the induction and maintenance of stemness in CSCs, such as the Wnt/β-catenin, Notch, STAT3, and Hedgehog pathways. In this review, we aim to review some of the ongoing CSC therapeutic targeting strategies in gastrointestinal malignancies.http://www.mdpi.com/2227-9059/7/1/17cancer stem cellBBI-608napabucasinSTAT3pancreatic cancergastric cancercolorectal cancerWnt/β-catenin |
| spellingShingle | Mohamad B. Sonbol Daniel H. Ahn Tanios Bekaii-Saab Therapeutic Targeting Strategies of Cancer Stem Cells in Gastrointestinal Malignancies Biomedicines cancer stem cell BBI-608 napabucasin STAT3 pancreatic cancer gastric cancer colorectal cancer Wnt/β-catenin |
| title | Therapeutic Targeting Strategies of Cancer Stem Cells in Gastrointestinal Malignancies |
| title_full | Therapeutic Targeting Strategies of Cancer Stem Cells in Gastrointestinal Malignancies |
| title_fullStr | Therapeutic Targeting Strategies of Cancer Stem Cells in Gastrointestinal Malignancies |
| title_full_unstemmed | Therapeutic Targeting Strategies of Cancer Stem Cells in Gastrointestinal Malignancies |
| title_short | Therapeutic Targeting Strategies of Cancer Stem Cells in Gastrointestinal Malignancies |
| title_sort | therapeutic targeting strategies of cancer stem cells in gastrointestinal malignancies |
| topic | cancer stem cell BBI-608 napabucasin STAT3 pancreatic cancer gastric cancer colorectal cancer Wnt/β-catenin |
| url | http://www.mdpi.com/2227-9059/7/1/17 |
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