UJI TOKSISITAS SUBKRONIS INFUSA DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav) PADA TIKUS: STUDI TERHADAP GAMBARAN MIKROSKOPIS JANTUNG DAN KADAR SGOT DARAH
Abstract: Red betel (Piper crocatum Ruiz & Pav) is one of the plants used as traditional medicine community. To determine the level of safety of long-term consumption, then tested subchronic toxicity. The study aimed to determine the relationship spectrum of toxic effects of infusion with change...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Universitas Sanata Dharma
2016-04-01
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| Series: | Jurnal Farmasi Sains dan Komunitas |
| Online Access: | http://e-journal.usd.ac.id/index.php/JFSK/article/view/105 |
| _version_ | 1818545324150489088 |
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| author | Ignasius Kuncarli Ipang Djunarko |
| author_facet | Ignasius Kuncarli Ipang Djunarko |
| author_sort | Ignasius Kuncarli |
| collection | DOAJ |
| description | Abstract: Red betel (Piper crocatum Ruiz & Pav) is one of the plants used as traditional medicine community. To determine the level of safety of long-term consumption, then tested subchronic toxicity. The study aimed to determine the relationship spectrum of toxic effects of infusion with changes in levels of serum glutamic oxaloacetic transaminase (SGOT) and cardiac histopathology. The study was purely experimental, randomized study design complete unidirectional pattern. A total of 40 Wistar rats (20 males and 20 females), 2-3 months were divided randomly into 4 groups: control group distilled water and 1.38; 2.07; 3.105 g/KgBW of red betel leaf infusion with administration once daily for 28 days. Observations were made before treatment and on day 28 by orbital sinus sampling through to measurement of blood levels of SGOT be analyzed by one way ANOVA and partially dissected mouse to see the damage to the heart. The results showed there was no significant change (p <0.05) in SGOT levels compared the control group. Histology showed no specific changes were observed after administrating 28 days of red betel leaf infusion. The red betel leaf infusion did not cause significant change in SGOT level and histology of heart.
Keywords : red betel, subchronic toxicity tests, SGOT, cardiac histology. |
| first_indexed | 2024-12-12T07:38:48Z |
| format | Article |
| id | doaj.art-9659528648624863bb5592f7f9a9ba40 |
| institution | Directory Open Access Journal |
| issn | 1693-5683 2527-7146 |
| language | English |
| last_indexed | 2024-12-12T07:38:48Z |
| publishDate | 2016-04-01 |
| publisher | Universitas Sanata Dharma |
| record_format | Article |
| series | Jurnal Farmasi Sains dan Komunitas |
| spelling | doaj.art-9659528648624863bb5592f7f9a9ba402022-12-22T00:32:51ZengUniversitas Sanata DharmaJurnal Farmasi Sains dan Komunitas1693-56832527-71462016-04-0111210.24071/jpsc.112105100UJI TOKSISITAS SUBKRONIS INFUSA DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav) PADA TIKUS: STUDI TERHADAP GAMBARAN MIKROSKOPIS JANTUNG DAN KADAR SGOT DARAHIgnasius KuncarliIpang DjunarkoAbstract: Red betel (Piper crocatum Ruiz & Pav) is one of the plants used as traditional medicine community. To determine the level of safety of long-term consumption, then tested subchronic toxicity. The study aimed to determine the relationship spectrum of toxic effects of infusion with changes in levels of serum glutamic oxaloacetic transaminase (SGOT) and cardiac histopathology. The study was purely experimental, randomized study design complete unidirectional pattern. A total of 40 Wistar rats (20 males and 20 females), 2-3 months were divided randomly into 4 groups: control group distilled water and 1.38; 2.07; 3.105 g/KgBW of red betel leaf infusion with administration once daily for 28 days. Observations were made before treatment and on day 28 by orbital sinus sampling through to measurement of blood levels of SGOT be analyzed by one way ANOVA and partially dissected mouse to see the damage to the heart. The results showed there was no significant change (p <0.05) in SGOT levels compared the control group. Histology showed no specific changes were observed after administrating 28 days of red betel leaf infusion. The red betel leaf infusion did not cause significant change in SGOT level and histology of heart. Keywords : red betel, subchronic toxicity tests, SGOT, cardiac histology.http://e-journal.usd.ac.id/index.php/JFSK/article/view/105 |
| spellingShingle | Ignasius Kuncarli Ipang Djunarko UJI TOKSISITAS SUBKRONIS INFUSA DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav) PADA TIKUS: STUDI TERHADAP GAMBARAN MIKROSKOPIS JANTUNG DAN KADAR SGOT DARAH Jurnal Farmasi Sains dan Komunitas |
| title | UJI TOKSISITAS SUBKRONIS INFUSA DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav) PADA TIKUS: STUDI TERHADAP GAMBARAN MIKROSKOPIS JANTUNG DAN KADAR SGOT DARAH |
| title_full | UJI TOKSISITAS SUBKRONIS INFUSA DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav) PADA TIKUS: STUDI TERHADAP GAMBARAN MIKROSKOPIS JANTUNG DAN KADAR SGOT DARAH |
| title_fullStr | UJI TOKSISITAS SUBKRONIS INFUSA DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav) PADA TIKUS: STUDI TERHADAP GAMBARAN MIKROSKOPIS JANTUNG DAN KADAR SGOT DARAH |
| title_full_unstemmed | UJI TOKSISITAS SUBKRONIS INFUSA DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav) PADA TIKUS: STUDI TERHADAP GAMBARAN MIKROSKOPIS JANTUNG DAN KADAR SGOT DARAH |
| title_short | UJI TOKSISITAS SUBKRONIS INFUSA DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav) PADA TIKUS: STUDI TERHADAP GAMBARAN MIKROSKOPIS JANTUNG DAN KADAR SGOT DARAH |
| title_sort | uji toksisitas subkronis infusa daun sirih merah piper crocatum ruiz pav pada tikus studi terhadap gambaran mikroskopis jantung dan kadar sgot darah |
| url | http://e-journal.usd.ac.id/index.php/JFSK/article/view/105 |
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