First direct evidence for direct cell-membrane penetrations of polycationic homopoly(amino acid)s produced by bacteria
Bacteria-derived polycationic homopoly(amino acid)s are reported for the first time to directly penetrate cell membrane and deliver proteins of interest into cells, representing a new type of cell penetrating peptides for intracellular delivery.
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-04110-4 |
| _version_ | 1811335320851972096 |
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| author | Yamato Takeuchi Kazunori Ushimaru Kohei Kaneda Chitose Maruyama Takashi Ito Kazuya Yamanaka Yasushi Ogasawara Hajime Katano Yasuo Kato Tohru Dairi Yoshimitsu Hamano |
| author_facet | Yamato Takeuchi Kazunori Ushimaru Kohei Kaneda Chitose Maruyama Takashi Ito Kazuya Yamanaka Yasushi Ogasawara Hajime Katano Yasuo Kato Tohru Dairi Yoshimitsu Hamano |
| author_sort | Yamato Takeuchi |
| collection | DOAJ |
| description | Bacteria-derived polycationic homopoly(amino acid)s are reported for the first time to directly penetrate cell membrane and deliver proteins of interest into cells, representing a new type of cell penetrating peptides for intracellular delivery. |
| first_indexed | 2024-04-13T17:22:25Z |
| format | Article |
| id | doaj.art-965b0e9e00634fa1934485e4592757fe |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-13T17:22:25Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-965b0e9e00634fa1934485e4592757fe2022-12-22T02:37:56ZengNature PortfolioCommunications Biology2399-36422022-10-015111410.1038/s42003-022-04110-4First direct evidence for direct cell-membrane penetrations of polycationic homopoly(amino acid)s produced by bacteriaYamato Takeuchi0Kazunori Ushimaru1Kohei Kaneda2Chitose Maruyama3Takashi Ito4Kazuya Yamanaka5Yasushi Ogasawara6Hajime Katano7Yasuo Kato8Tohru Dairi9Yoshimitsu Hamano10Graduate School of Bioscience and Biotechnology, Fukui Prefectural UniversityGraduate School of Bioscience and Biotechnology, Fukui Prefectural UniversityGraduate School of Bioscience and Biotechnology, Fukui Prefectural UniversityGraduate School of Bioscience and Biotechnology, Fukui Prefectural UniversityGraduate School of Bioscience and Biotechnology, Fukui Prefectural UniversityDepartment of Life Science & Technology, Kansai UniversityGraduate School of Engineering, Hokkaido UniversityGraduate School of Bioscience and Biotechnology, Fukui Prefectural UniversityDepartment of Biotechnology, Toyama Prefectural UniversityGraduate School of Engineering, Hokkaido UniversityGraduate School of Bioscience and Biotechnology, Fukui Prefectural UniversityBacteria-derived polycationic homopoly(amino acid)s are reported for the first time to directly penetrate cell membrane and deliver proteins of interest into cells, representing a new type of cell penetrating peptides for intracellular delivery.https://doi.org/10.1038/s42003-022-04110-4 |
| spellingShingle | Yamato Takeuchi Kazunori Ushimaru Kohei Kaneda Chitose Maruyama Takashi Ito Kazuya Yamanaka Yasushi Ogasawara Hajime Katano Yasuo Kato Tohru Dairi Yoshimitsu Hamano First direct evidence for direct cell-membrane penetrations of polycationic homopoly(amino acid)s produced by bacteria Communications Biology |
| title | First direct evidence for direct cell-membrane penetrations of polycationic homopoly(amino acid)s produced by bacteria |
| title_full | First direct evidence for direct cell-membrane penetrations of polycationic homopoly(amino acid)s produced by bacteria |
| title_fullStr | First direct evidence for direct cell-membrane penetrations of polycationic homopoly(amino acid)s produced by bacteria |
| title_full_unstemmed | First direct evidence for direct cell-membrane penetrations of polycationic homopoly(amino acid)s produced by bacteria |
| title_short | First direct evidence for direct cell-membrane penetrations of polycationic homopoly(amino acid)s produced by bacteria |
| title_sort | first direct evidence for direct cell membrane penetrations of polycationic homopoly amino acid s produced by bacteria |
| url | https://doi.org/10.1038/s42003-022-04110-4 |
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