Histologic evidence of tracheal stenosis directly resulting from SARS-CoV-2 tissue infiltration, a case series
Abstract Background There has been an anecdotal increase in the incidence of tracheal stenosis that has coincided with the SARS-CoV-2 pandemic. Case presentation This is a case series in which we report clinical and pathologic findings of two patients who subsequently developed subglottic tracheal s...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-05-01
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| Series: | Journal of Cardiothoracic Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13019-022-01839-1 |
| Summary: | Abstract Background There has been an anecdotal increase in the incidence of tracheal stenosis that has coincided with the SARS-CoV-2 pandemic. Case presentation This is a case series in which we report clinical and pathologic findings of two patients who subsequently developed subglottic tracheal stenosis after having been hospitalized with COVID-19 pneumonia. Histopathologic analysis of tissue from these patients shows features consistent with tissue infiltrated with SARS-CoV-2 virus, namely multinucleated syncytial cells with prominent nucleoli. Conclusion Our findings directly implicate SARS-CoV-2 in the pathogenesis of tracheal stenosis. |
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| ISSN: | 1749-8090 |