Circular RNAs Are Promising Biomarkers in Liquid Biopsy for the Diagnosis of Non-small Cell Lung Cancer
The high incidence and mortality of lung cancer make early detection of lung cancer particularly important. At present, the diagnosis of lung cancer mainly depends on diagnostic imaging and tissue biopsy. However, current diagnostics are not satisfactory owing to the low specificity and inability of...
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Frontiers Media S.A.
2021-05-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2021.625722/full |
| _version_ | 1818648215651614720 |
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| author | Lanxiang Huang Lanxiang Huang Yuan Rong Yuan Rong Xuan Tang Xuan Tang Kezhen Yi Kezhen Yi Jianyuan Wu Fubing Wang Fubing Wang Fubing Wang |
| author_facet | Lanxiang Huang Lanxiang Huang Yuan Rong Yuan Rong Xuan Tang Xuan Tang Kezhen Yi Kezhen Yi Jianyuan Wu Fubing Wang Fubing Wang Fubing Wang |
| author_sort | Lanxiang Huang |
| collection | DOAJ |
| description | The high incidence and mortality of lung cancer make early detection of lung cancer particularly important. At present, the diagnosis of lung cancer mainly depends on diagnostic imaging and tissue biopsy. However, current diagnostics are not satisfactory owing to the low specificity and inability of multiple sampling. Accumulating evidence indicates that circular RNAs (circRNAs) play a critical role in cancer progression and are promising cancer biomarkers. In particular, circRNAs are considered novel specific diagnostic markers for non-small cell lung cancer (NSCLC). Liquid biopsy is an important method in the early diagnosis of cancer due to its high sensitivity and specificity, as well as the possibility of performing multiple sampling. circRNAs are stably present in exosomes and sometimes become part of circulating nucleic acids, making them ideal for liquid biopsy. In this review, we summarize the advances in the research on circRNAs in NSCLC, and also highlight their potential applications for NSCLC detection. |
| first_indexed | 2024-12-17T01:14:53Z |
| format | Article |
| id | doaj.art-965d82f6e0044f7f9dd968496baa3f60 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-17T01:14:53Z |
| publishDate | 2021-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-965d82f6e0044f7f9dd968496baa3f602022-12-21T22:09:01ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2021-05-01810.3389/fmolb.2021.625722625722Circular RNAs Are Promising Biomarkers in Liquid Biopsy for the Diagnosis of Non-small Cell Lung CancerLanxiang Huang0Lanxiang Huang1Yuan Rong2Yuan Rong3Xuan Tang4Xuan Tang5Kezhen Yi6Kezhen Yi7Jianyuan Wu8Fubing Wang9Fubing Wang10Fubing Wang11Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, ChinaCenter for Single-Cell Omics and Tumor Liquid Biopsy, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, ChinaCenter for Single-Cell Omics and Tumor Liquid Biopsy, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, ChinaCenter for Single-Cell Omics and Tumor Liquid Biopsy, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, ChinaCenter for Single-Cell Omics and Tumor Liquid Biopsy, Zhongnan Hospital of Wuhan University, Wuhan, ChinaClinical Trial Center, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, ChinaCenter for Single-Cell Omics and Tumor Liquid Biopsy, Zhongnan Hospital of Wuhan University, Wuhan, ChinaWuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, ChinaThe high incidence and mortality of lung cancer make early detection of lung cancer particularly important. At present, the diagnosis of lung cancer mainly depends on diagnostic imaging and tissue biopsy. However, current diagnostics are not satisfactory owing to the low specificity and inability of multiple sampling. Accumulating evidence indicates that circular RNAs (circRNAs) play a critical role in cancer progression and are promising cancer biomarkers. In particular, circRNAs are considered novel specific diagnostic markers for non-small cell lung cancer (NSCLC). Liquid biopsy is an important method in the early diagnosis of cancer due to its high sensitivity and specificity, as well as the possibility of performing multiple sampling. circRNAs are stably present in exosomes and sometimes become part of circulating nucleic acids, making them ideal for liquid biopsy. In this review, we summarize the advances in the research on circRNAs in NSCLC, and also highlight their potential applications for NSCLC detection.https://www.frontiersin.org/articles/10.3389/fmolb.2021.625722/fullcircular RNAsexosomeliquid biopsynon-small cell lung cancerbiomarker |
| spellingShingle | Lanxiang Huang Lanxiang Huang Yuan Rong Yuan Rong Xuan Tang Xuan Tang Kezhen Yi Kezhen Yi Jianyuan Wu Fubing Wang Fubing Wang Fubing Wang Circular RNAs Are Promising Biomarkers in Liquid Biopsy for the Diagnosis of Non-small Cell Lung Cancer Frontiers in Molecular Biosciences circular RNAs exosome liquid biopsy non-small cell lung cancer biomarker |
| title | Circular RNAs Are Promising Biomarkers in Liquid Biopsy for the Diagnosis of Non-small Cell Lung Cancer |
| title_full | Circular RNAs Are Promising Biomarkers in Liquid Biopsy for the Diagnosis of Non-small Cell Lung Cancer |
| title_fullStr | Circular RNAs Are Promising Biomarkers in Liquid Biopsy for the Diagnosis of Non-small Cell Lung Cancer |
| title_full_unstemmed | Circular RNAs Are Promising Biomarkers in Liquid Biopsy for the Diagnosis of Non-small Cell Lung Cancer |
| title_short | Circular RNAs Are Promising Biomarkers in Liquid Biopsy for the Diagnosis of Non-small Cell Lung Cancer |
| title_sort | circular rnas are promising biomarkers in liquid biopsy for the diagnosis of non small cell lung cancer |
| topic | circular RNAs exosome liquid biopsy non-small cell lung cancer biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2021.625722/full |
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