Circulating microRNA as a Biomarker for Coronary Artery Disease
Coronary artery disease (CAD) is the leading cause of sudden cardiac death in adults, and new methods of predicting disease and risk-stratifying patients will help guide intervention in order to reduce this burden. Current CAD detection involves multiple modalities, but the consideration of other bi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/10/10/1354 |
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| author | Ibrahim T. Fazmin Zakaria Achercouk Charlotte E. Edling Asri Said Kamalan Jeevaratnam |
| author_facet | Ibrahim T. Fazmin Zakaria Achercouk Charlotte E. Edling Asri Said Kamalan Jeevaratnam |
| author_sort | Ibrahim T. Fazmin |
| collection | DOAJ |
| description | Coronary artery disease (CAD) is the leading cause of sudden cardiac death in adults, and new methods of predicting disease and risk-stratifying patients will help guide intervention in order to reduce this burden. Current CAD detection involves multiple modalities, but the consideration of other biomarkers will help improve reliability. The aim of this narrative review is to help researchers and clinicians appreciate the growing relevance of miRNA in CAD and its potential as a biomarker, and also to suggest useful miRNA that may be targets for future study. We sourced information from several databases, namely PubMed, Scopus, and Google Scholar, when collating evidentiary information. MicroRNAs (miRNA) are short, noncoding RNAs that are relevant in cardiovascular physiology and pathophysiology, playing roles in cardiac hypertrophy, maintenance of vascular tone, and responses to vascular injury. CAD is associated with changes in miRNA expression profiles, and so are its risk factors, such as abnormal lipid metabolism and inflammation. Thus, they may potentially be biomarkers of CAD. Nevertheless, there are limitations in using miRNA. These include cost and the presence of several confounding factors that may affect miRNA profiles. Furthermore, there is difficulty in the normalisation of miRNA values between published studies, due to pre-analytical variations in samples. |
| first_indexed | 2024-03-10T16:07:50Z |
| format | Article |
| id | doaj.art-965eed8a299048b8a09d6cf61f572a29 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T16:07:50Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-965eed8a299048b8a09d6cf61f572a292023-11-20T14:46:22ZengMDPI AGBiomolecules2218-273X2020-09-011010135410.3390/biom10101354Circulating microRNA as a Biomarker for Coronary Artery DiseaseIbrahim T. Fazmin0Zakaria Achercouk1Charlotte E. Edling2Asri Said3Kamalan Jeevaratnam4Faculty of Health and Medical Science, University of Surrey, Guildford GU2 7AL, UKFaculty of Health and Medical Science, University of Surrey, Guildford GU2 7AL, UKFaculty of Health and Medical Science, University of Surrey, Guildford GU2 7AL, UKSchool of Medicine, University Malaysia Sarawak, Kota Samarahan 94300, Sarawak, MalaysiaFaculty of Health and Medical Science, University of Surrey, Guildford GU2 7AL, UKCoronary artery disease (CAD) is the leading cause of sudden cardiac death in adults, and new methods of predicting disease and risk-stratifying patients will help guide intervention in order to reduce this burden. Current CAD detection involves multiple modalities, but the consideration of other biomarkers will help improve reliability. The aim of this narrative review is to help researchers and clinicians appreciate the growing relevance of miRNA in CAD and its potential as a biomarker, and also to suggest useful miRNA that may be targets for future study. We sourced information from several databases, namely PubMed, Scopus, and Google Scholar, when collating evidentiary information. MicroRNAs (miRNA) are short, noncoding RNAs that are relevant in cardiovascular physiology and pathophysiology, playing roles in cardiac hypertrophy, maintenance of vascular tone, and responses to vascular injury. CAD is associated with changes in miRNA expression profiles, and so are its risk factors, such as abnormal lipid metabolism and inflammation. Thus, they may potentially be biomarkers of CAD. Nevertheless, there are limitations in using miRNA. These include cost and the presence of several confounding factors that may affect miRNA profiles. Furthermore, there is difficulty in the normalisation of miRNA values between published studies, due to pre-analytical variations in samples.https://www.mdpi.com/2218-273X/10/10/1354coronary artery diseasebiomarkersnoncoding RNAmicroRNA |
| spellingShingle | Ibrahim T. Fazmin Zakaria Achercouk Charlotte E. Edling Asri Said Kamalan Jeevaratnam Circulating microRNA as a Biomarker for Coronary Artery Disease Biomolecules coronary artery disease biomarkers noncoding RNA microRNA |
| title | Circulating microRNA as a Biomarker for Coronary Artery Disease |
| title_full | Circulating microRNA as a Biomarker for Coronary Artery Disease |
| title_fullStr | Circulating microRNA as a Biomarker for Coronary Artery Disease |
| title_full_unstemmed | Circulating microRNA as a Biomarker for Coronary Artery Disease |
| title_short | Circulating microRNA as a Biomarker for Coronary Artery Disease |
| title_sort | circulating microrna as a biomarker for coronary artery disease |
| topic | coronary artery disease biomarkers noncoding RNA microRNA |
| url | https://www.mdpi.com/2218-273X/10/10/1354 |
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