Contrast-induced acute kidney injury in chronic coronary artery disease patients with diabetes mellitus and obesity
Aim.To assess the influence of diabetes mellitus and obesity on contrast-induced acute kidney injury risk in patients with chronic coronary artery disease requiring percutaneous coronary intervention. Materials and methods.1023 patients with chronic coronary artery disease were enrolled in a pros...
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2020-11-01
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| Series: | Терапевтический архив |
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| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/50972/34461 |
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| author | O. Iu. Mironova I. I. Staroverov O. A. Sivakova A. D. Deev V. V. Fomin |
| author_facet | O. Iu. Mironova I. I. Staroverov O. A. Sivakova A. D. Deev V. V. Fomin |
| author_sort | O. Iu. Mironova |
| collection | DOAJ |
| description | Aim.To assess the influence of diabetes mellitus and obesity on contrast-induced acute kidney injury risk in patients with chronic coronary artery disease requiring percutaneous coronary intervention.
Materials and methods.1023 patients with chronic coronary artery disease were enrolled in a prospective, open, cohort study (ClinicalTrials.gov ID NCT04014153). Contrast-induced acute kidney injury was defined as an increase of 25% or more, or an absolute increase of 0.5 mg/dl or more in serum creatinine from baseline value, assessed at 48 hours following the administration of the contrast. The majority of the patients were overweight male ones with BMI 29.25.5 kg/m2. The primary endpoint of the study was the development of contrast-induced acute kidney injury according to KDIGO criteria.
Results.The prevalence of contrast-induced acute kidney injury was 12.9% (132 patients). 21.2% suffered from diabetes mellitus, 43% were obese and 12.9% had both diabetes mellitus and obesity. Diabetes wasnt a statistically significant independent risk factor of the contrast-induced acute kidney injury, as well as the combination of diabetes and obesity. In the group of obese patients the prevalence of contrast-induced acute kidney injury was higher (13.4%vs12.5%), but didnt meet statistical significance (p=0.7, OR 0.924, 95% CI 0.641.325). According to the multiple logistic regression model, female gender, age, BMI, weight, arterial hypertension, baseline creatinine were the risk factors of the contrast-induced acute kidney injury development (AUC 0.742,p0.0001).
Conclusion.Diabetes mellitus was not associated with higher incidence of contrast-induced acute kidney injury. The prevalence of contrast-induced kidney injury was higher in the group of patients with BMI30 kg/m2, but didnt meet statistical significance and needs further evaluation in larger studies. |
| first_indexed | 2024-12-16T17:05:27Z |
| format | Article |
| id | doaj.art-965f94c1bb7b46f98d451fc09581c745 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-16T17:05:27Z |
| publishDate | 2020-11-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-965f94c1bb7b46f98d451fc09581c7452022-12-21T22:23:35Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422020-11-019210293310.26442/00403660.2020.10.00075346366Contrast-induced acute kidney injury in chronic coronary artery disease patients with diabetes mellitus and obesityO. Iu. Mironova0I. I. Staroverov1O. A. Sivakova2A. D. Deev3V. V. Fomin4Sechenov First Moscow State Medical University (Sechenov University)National Medical Research Center of CardiologyNational Medical Research Center of CardiologyNational Research Center for Preventive MedicineSechenov First Moscow State Medical University (Sechenov University)Aim.To assess the influence of diabetes mellitus and obesity on contrast-induced acute kidney injury risk in patients with chronic coronary artery disease requiring percutaneous coronary intervention. Materials and methods.1023 patients with chronic coronary artery disease were enrolled in a prospective, open, cohort study (ClinicalTrials.gov ID NCT04014153). Contrast-induced acute kidney injury was defined as an increase of 25% or more, or an absolute increase of 0.5 mg/dl or more in serum creatinine from baseline value, assessed at 48 hours following the administration of the contrast. The majority of the patients were overweight male ones with BMI 29.25.5 kg/m2. The primary endpoint of the study was the development of contrast-induced acute kidney injury according to KDIGO criteria. Results.The prevalence of contrast-induced acute kidney injury was 12.9% (132 patients). 21.2% suffered from diabetes mellitus, 43% were obese and 12.9% had both diabetes mellitus and obesity. Diabetes wasnt a statistically significant independent risk factor of the contrast-induced acute kidney injury, as well as the combination of diabetes and obesity. In the group of obese patients the prevalence of contrast-induced acute kidney injury was higher (13.4%vs12.5%), but didnt meet statistical significance (p=0.7, OR 0.924, 95% CI 0.641.325). According to the multiple logistic regression model, female gender, age, BMI, weight, arterial hypertension, baseline creatinine were the risk factors of the contrast-induced acute kidney injury development (AUC 0.742,p0.0001). Conclusion.Diabetes mellitus was not associated with higher incidence of contrast-induced acute kidney injury. The prevalence of contrast-induced kidney injury was higher in the group of patients with BMI30 kg/m2, but didnt meet statistical significance and needs further evaluation in larger studies.https://ter-arkhiv.ru/0040-3660/article/viewFile/50972/34461contrast-induced acute kidney injurycontrast-induced nephropathycontrast-associated acute kidney injurycoronary artery diseasediabetes mellitusobesitypercutaneous coronary interventioncontrast |
| spellingShingle | O. Iu. Mironova I. I. Staroverov O. A. Sivakova A. D. Deev V. V. Fomin Contrast-induced acute kidney injury in chronic coronary artery disease patients with diabetes mellitus and obesity Терапевтический архив contrast-induced acute kidney injury contrast-induced nephropathy contrast-associated acute kidney injury coronary artery disease diabetes mellitus obesity percutaneous coronary intervention contrast |
| title | Contrast-induced acute kidney injury in chronic coronary artery disease patients with diabetes mellitus and obesity |
| title_full | Contrast-induced acute kidney injury in chronic coronary artery disease patients with diabetes mellitus and obesity |
| title_fullStr | Contrast-induced acute kidney injury in chronic coronary artery disease patients with diabetes mellitus and obesity |
| title_full_unstemmed | Contrast-induced acute kidney injury in chronic coronary artery disease patients with diabetes mellitus and obesity |
| title_short | Contrast-induced acute kidney injury in chronic coronary artery disease patients with diabetes mellitus and obesity |
| title_sort | contrast induced acute kidney injury in chronic coronary artery disease patients with diabetes mellitus and obesity |
| topic | contrast-induced acute kidney injury contrast-induced nephropathy contrast-associated acute kidney injury coronary artery disease diabetes mellitus obesity percutaneous coronary intervention contrast |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/50972/34461 |
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