Characteristics and Challenges of Epilepsy in Children with Cerebral Palsy—A Population-Based Study
The aim of this population-based study was to describe the prevalence and characteristics of epilepsy in children with cerebral palsy (CP), focusing on antiseizure medication (ASM) and seizure outcome. Findings were related to CP type, gross motor function and associated impairments. Data on all 140...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/1/346 |
| _version_ | 1797625478004080640 |
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| author | Ana Dos Santos Rufino Magnus Påhlman Ingrid Olsson Kate Himmelmann |
| author_facet | Ana Dos Santos Rufino Magnus Påhlman Ingrid Olsson Kate Himmelmann |
| author_sort | Ana Dos Santos Rufino |
| collection | DOAJ |
| description | The aim of this population-based study was to describe the prevalence and characteristics of epilepsy in children with cerebral palsy (CP), focusing on antiseizure medication (ASM) and seizure outcome. Findings were related to CP type, gross motor function and associated impairments. Data on all 140 children with CP born in 2003–2006 were taken from the CP register of Western Sweden. Medical records were reviewed at ages 9–12 and 13–16 years. In total 43% had a diagnosis of epilepsy. Epilepsy was more common in children with dyskinetic CP, who more often had a history of infantile spasms, continuous spike-and-wave during sleep and status epilepticus. Neonatal seizures, severe intellectual disability, severe motor disability and autism were associated with a higher risk of epilepsy. Many children were on polytherapy, and valproate was frequently used, even in girls. At age 13–16 years, 45% of the children with epilepsy were seizure free for at least one year. Onset after 2 years of age, female sex and white matter injury were associated with good seizure outcome. Despite the risk of relapse, reduction or discontinuation of ASM could be an option in selected cases. It is important to optimize ASM and to consider the possibility of epilepsy surgery. |
| first_indexed | 2024-03-11T09:57:03Z |
| format | Article |
| id | doaj.art-96601a816a914ec1878f59a776ecdd78 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T09:57:03Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-96601a816a914ec1878f59a776ecdd782023-11-16T15:44:55ZengMDPI AGJournal of Clinical Medicine2077-03832023-01-0112134610.3390/jcm12010346Characteristics and Challenges of Epilepsy in Children with Cerebral Palsy—A Population-Based StudyAna Dos Santos Rufino0Magnus Påhlman1Ingrid Olsson2Kate Himmelmann3Paediatric Neurology, Queen Silvia Children’s Hospital, Sahlgrenska University Hospital, 41685 Gothenburg, SwedenPaediatric Neurology, Queen Silvia Children’s Hospital, Sahlgrenska University Hospital, 41685 Gothenburg, SwedenPaediatric Neurology, Queen Silvia Children’s Hospital, Sahlgrenska University Hospital, 41685 Gothenburg, SwedenPaediatric Neurology, Queen Silvia Children’s Hospital, Sahlgrenska University Hospital, 41685 Gothenburg, SwedenThe aim of this population-based study was to describe the prevalence and characteristics of epilepsy in children with cerebral palsy (CP), focusing on antiseizure medication (ASM) and seizure outcome. Findings were related to CP type, gross motor function and associated impairments. Data on all 140 children with CP born in 2003–2006 were taken from the CP register of Western Sweden. Medical records were reviewed at ages 9–12 and 13–16 years. In total 43% had a diagnosis of epilepsy. Epilepsy was more common in children with dyskinetic CP, who more often had a history of infantile spasms, continuous spike-and-wave during sleep and status epilepticus. Neonatal seizures, severe intellectual disability, severe motor disability and autism were associated with a higher risk of epilepsy. Many children were on polytherapy, and valproate was frequently used, even in girls. At age 13–16 years, 45% of the children with epilepsy were seizure free for at least one year. Onset after 2 years of age, female sex and white matter injury were associated with good seizure outcome. Despite the risk of relapse, reduction or discontinuation of ASM could be an option in selected cases. It is important to optimize ASM and to consider the possibility of epilepsy surgery.https://www.mdpi.com/2077-0383/12/1/346epilepsycerebral palsychildrenneuroimagingseizure outcome |
| spellingShingle | Ana Dos Santos Rufino Magnus Påhlman Ingrid Olsson Kate Himmelmann Characteristics and Challenges of Epilepsy in Children with Cerebral Palsy—A Population-Based Study Journal of Clinical Medicine epilepsy cerebral palsy children neuroimaging seizure outcome |
| title | Characteristics and Challenges of Epilepsy in Children with Cerebral Palsy—A Population-Based Study |
| title_full | Characteristics and Challenges of Epilepsy in Children with Cerebral Palsy—A Population-Based Study |
| title_fullStr | Characteristics and Challenges of Epilepsy in Children with Cerebral Palsy—A Population-Based Study |
| title_full_unstemmed | Characteristics and Challenges of Epilepsy in Children with Cerebral Palsy—A Population-Based Study |
| title_short | Characteristics and Challenges of Epilepsy in Children with Cerebral Palsy—A Population-Based Study |
| title_sort | characteristics and challenges of epilepsy in children with cerebral palsy a population based study |
| topic | epilepsy cerebral palsy children neuroimaging seizure outcome |
| url | https://www.mdpi.com/2077-0383/12/1/346 |
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