Determination of magnetic motor evoked potential latency time cutoff values for detection of spinal cord dysfunction in horses
Abstract Background Transcranial magnetic stimulation (TMS) and recording of magnetic motor evoked potentials (MMEP) can detect neurological dysfunction in horses but cutoff values based on confirmed spinal cord dysfunction are lacking. Objectives To determine latency time cutoff for neurological dy...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-09-01
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| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.15576 |
| _version_ | 1811251167701762048 |
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| author | Joke Rijckaert Bart Pardon Veronique Saey Els Raes Luc Van Ham Richard Ducatelle Gunther vanLoon Piet Deprez |
| author_facet | Joke Rijckaert Bart Pardon Veronique Saey Els Raes Luc Van Ham Richard Ducatelle Gunther vanLoon Piet Deprez |
| author_sort | Joke Rijckaert |
| collection | DOAJ |
| description | Abstract Background Transcranial magnetic stimulation (TMS) and recording of magnetic motor evoked potentials (MMEP) can detect neurological dysfunction in horses but cutoff values based on confirmed spinal cord dysfunction are lacking. Objectives To determine latency time cutoff for neurological dysfunction. Animals Five control horses and 17 horses with proprioceptive ataxia. Methods Case‐control study with receiver operating characteristic curve analysis, based on diagnostic imaging, TMS, and histopathological findings. Horses were included if all 3 examinations were performed. Results Diagnostic imaging and histopathology did not show abnormalities in the control group but confirmed spinal cord compression in 14 of 17 ataxic horses. In the remaining 3 horses, histopathological lesions were mild to severe, but diagnostic imaging did not confirm spinal cord compression. In control horses, latency time values of thoracic and pelvic limbs were significantly lower than in ataxic horses (20 ± 1 vs 34 ± 16 milliseconds, P = .05; and 39 ± 1 vs 78 ± 26 milliseconds, P = .004). Optimal cutoff values to detect spinal cord dysfunction were 22 milliseconds (sensitivity [95% CI interval], 88% [73%‐100%]; specificity, 100% [100%‐100%]) in thoracic and 40 milliseconds (sensitivity, 94% [83%‐100%]; specificity, 100% [100%‐100%]) in pelvic limbs. To detect spinal cord dysfunction caused by compression, the optimal cutoff for thoracic limbs remained 22 milliseconds, while it increased to 43 milliseconds in pelvic limbs (sensitivity, 100% [100%‐100%]; specificity, 100% [100%‐100%] for thoracic and pelvic limbs). Conclusions and Clinical Importance Magnetic motor evoked potential analysis using these cutoff values is a promising diagnostic tool for spinal cord dysfunction diagnosis in horses. |
| first_indexed | 2024-04-12T16:16:39Z |
| format | Article |
| id | doaj.art-96601cdcac8e42619f8dd6b6708589e6 |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-04-12T16:16:39Z |
| publishDate | 2019-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-96601cdcac8e42619f8dd6b6708589e62022-12-22T03:25:43ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762019-09-013352312231810.1111/jvim.15576Determination of magnetic motor evoked potential latency time cutoff values for detection of spinal cord dysfunction in horsesJoke Rijckaert0Bart Pardon1Veronique Saey2Els Raes3Luc Van Ham4Richard Ducatelle5Gunther vanLoon6Piet Deprez7Department of Large Animal Internal Medicine Faculty of Veterinary Medicine, Ghent University Merelbeke BelgiumDepartment of Large Animal Internal Medicine Faculty of Veterinary Medicine, Ghent University Merelbeke BelgiumDepartment of Pathology, Bacteriology and Poultry Diseases Ghent University Merelbeke BelgiumDepartment of Veterinary Medical Imaging and Small Animal Orthopedics Ghent University Merelbeke BelgiumSmall Animal Department Faculty of Veterinary Medicine, Ghent University Merelbeke BelgiumDepartment of Pathology, Bacteriology and Poultry Diseases Ghent University Merelbeke BelgiumDepartment of Large Animal Internal Medicine Faculty of Veterinary Medicine, Ghent University Merelbeke BelgiumDepartment of Large Animal Internal Medicine Faculty of Veterinary Medicine, Ghent University Merelbeke BelgiumAbstract Background Transcranial magnetic stimulation (TMS) and recording of magnetic motor evoked potentials (MMEP) can detect neurological dysfunction in horses but cutoff values based on confirmed spinal cord dysfunction are lacking. Objectives To determine latency time cutoff for neurological dysfunction. Animals Five control horses and 17 horses with proprioceptive ataxia. Methods Case‐control study with receiver operating characteristic curve analysis, based on diagnostic imaging, TMS, and histopathological findings. Horses were included if all 3 examinations were performed. Results Diagnostic imaging and histopathology did not show abnormalities in the control group but confirmed spinal cord compression in 14 of 17 ataxic horses. In the remaining 3 horses, histopathological lesions were mild to severe, but diagnostic imaging did not confirm spinal cord compression. In control horses, latency time values of thoracic and pelvic limbs were significantly lower than in ataxic horses (20 ± 1 vs 34 ± 16 milliseconds, P = .05; and 39 ± 1 vs 78 ± 26 milliseconds, P = .004). Optimal cutoff values to detect spinal cord dysfunction were 22 milliseconds (sensitivity [95% CI interval], 88% [73%‐100%]; specificity, 100% [100%‐100%]) in thoracic and 40 milliseconds (sensitivity, 94% [83%‐100%]; specificity, 100% [100%‐100%]) in pelvic limbs. To detect spinal cord dysfunction caused by compression, the optimal cutoff for thoracic limbs remained 22 milliseconds, while it increased to 43 milliseconds in pelvic limbs (sensitivity, 100% [100%‐100%]; specificity, 100% [100%‐100%] for thoracic and pelvic limbs). Conclusions and Clinical Importance Magnetic motor evoked potential analysis using these cutoff values is a promising diagnostic tool for spinal cord dysfunction diagnosis in horses.https://doi.org/10.1111/jvim.15576ataxiacervical radiographscervical vertebral malformationmyelogramtranscranial magnetic stimulation |
| spellingShingle | Joke Rijckaert Bart Pardon Veronique Saey Els Raes Luc Van Ham Richard Ducatelle Gunther vanLoon Piet Deprez Determination of magnetic motor evoked potential latency time cutoff values for detection of spinal cord dysfunction in horses Journal of Veterinary Internal Medicine ataxia cervical radiographs cervical vertebral malformation myelogram transcranial magnetic stimulation |
| title | Determination of magnetic motor evoked potential latency time cutoff values for detection of spinal cord dysfunction in horses |
| title_full | Determination of magnetic motor evoked potential latency time cutoff values for detection of spinal cord dysfunction in horses |
| title_fullStr | Determination of magnetic motor evoked potential latency time cutoff values for detection of spinal cord dysfunction in horses |
| title_full_unstemmed | Determination of magnetic motor evoked potential latency time cutoff values for detection of spinal cord dysfunction in horses |
| title_short | Determination of magnetic motor evoked potential latency time cutoff values for detection of spinal cord dysfunction in horses |
| title_sort | determination of magnetic motor evoked potential latency time cutoff values for detection of spinal cord dysfunction in horses |
| topic | ataxia cervical radiographs cervical vertebral malformation myelogram transcranial magnetic stimulation |
| url | https://doi.org/10.1111/jvim.15576 |
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