Comparison between parameters of muscle performance and inflammatory biomarkers of non-sarcopenic and sarcopenic elderly women
Lygia Paccini Lustosa,1 Patrícia Parreira Batista,1 Daniele Sirineu Pereira,2 Leani Souza Máximo Pereira,1 Aline Scianni,1 Giane Amorim Ribeiro-Samora1 1Physical Therapy Department, Universidade Federal de Minas Gerais, Belo Horizonte, 2Physical Therapy Department, Universidad...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2017-08-01
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| Series: | Clinical Interventions in Aging |
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| Online Access: | https://www.dovepress.com/comparison-between-parameters-of-muscle-performance-and-inflammatory-b-peer-reviewed-article-CIA |
| _version_ | 1818743371845337088 |
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| author | Lustosa LP Batista PP Pereira DS Pereira LS Scianni A Ribeiro-Samora GA |
| author_facet | Lustosa LP Batista PP Pereira DS Pereira LS Scianni A Ribeiro-Samora GA |
| author_sort | Lustosa LP |
| collection | DOAJ |
| description | Lygia Paccini Lustosa,1 Patrícia Parreira Batista,1 Daniele Sirineu Pereira,2 Leani Souza Máximo Pereira,1 Aline Scianni,1 Giane Amorim Ribeiro-Samora1 1Physical Therapy Department, Universidade Federal de Minas Gerais, Belo Horizonte, 2Physical Therapy Department, Universidade Federal de Alfenas, Alfenas, Brazil Background: Sarcopenia is a multifactorial geriatric syndrome with complex interrelationships. Increased plasma levels of inflammatory mediators increase the catabolic stimuli of the musculature, thereby causing a decrease in mass and muscular function. Objective: The objective of this study was to compare the performance of the knee extensors test (by isokinetic dynamometer) and plasma levels of interleukin-6 (IL-6) and soluble receptors of tumor necrosis factor alpha (sTNFR1) between sarcopenics and non-sarcopenics community-dwelling elderly women residents of Brazil. Material and methods: The diagnosis of sarcopenia included measurements of body composition (by densitometry with dual energy source of X-ray), handgrip strength (by Jamar® dynamometer), and the usual gait velocity according to the recommendations of the European Working Group on Sarcopenia in Older People. In both sarcopenics and non-sarcopenics elderly women, we evaluated the muscle function by knee extensors test (using an isokinetic dynamometer Byodex System 4 Pro®) at angular speeds of 60°/s and 180°/s) and also we evaluated the plasma concentrations of IL-6 and sTNFR1. Comparisons of muscle performance between groups were carried out using mixed factorial ANOVA with post hoc Bonferroni test; sTNFR1 and IL-6 variables were analyzed by applying Mann–Whitney U test. Results: Statistical differences were observed between groups regarding muscle power (P=0.01), total work adjusted to body weight (P=0.01) at a rate of 180°/s, and plasma levels of sTNFR1 (P=0.01). Conclusion: Sarcopenic elder women showed lower performance of the lower limbs, especially at a higher speed, predisposing these older women to greater vulnerability in functional activities that require agility and postural stability. Plasma levels of sTNFR1 were higher for non-sarcopenics elderlies. However, due to the observational nature of the study, it was impossible to infer causality among the variables surveyed. Keywords: sarcopenia, muscle performance, inflammatory mediators, aging |
| first_indexed | 2024-12-18T02:27:21Z |
| format | Article |
| id | doaj.art-966052982c3f491b9666f2d3829e2673 |
| institution | Directory Open Access Journal |
| issn | 1178-1998 |
| language | English |
| last_indexed | 2024-12-18T02:27:21Z |
| publishDate | 2017-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Interventions in Aging |
| spelling | doaj.art-966052982c3f491b9666f2d3829e26732022-12-21T21:24:00ZengDove Medical PressClinical Interventions in Aging1178-19982017-08-01Volume 121183119134068Comparison between parameters of muscle performance and inflammatory biomarkers of non-sarcopenic and sarcopenic elderly womenLustosa LPBatista PPPereira DSPereira LSScianni ARibeiro-Samora GALygia Paccini Lustosa,1 Patrícia Parreira Batista,1 Daniele Sirineu Pereira,2 Leani Souza Máximo Pereira,1 Aline Scianni,1 Giane Amorim Ribeiro-Samora1 1Physical Therapy Department, Universidade Federal de Minas Gerais, Belo Horizonte, 2Physical Therapy Department, Universidade Federal de Alfenas, Alfenas, Brazil Background: Sarcopenia is a multifactorial geriatric syndrome with complex interrelationships. Increased plasma levels of inflammatory mediators increase the catabolic stimuli of the musculature, thereby causing a decrease in mass and muscular function. Objective: The objective of this study was to compare the performance of the knee extensors test (by isokinetic dynamometer) and plasma levels of interleukin-6 (IL-6) and soluble receptors of tumor necrosis factor alpha (sTNFR1) between sarcopenics and non-sarcopenics community-dwelling elderly women residents of Brazil. Material and methods: The diagnosis of sarcopenia included measurements of body composition (by densitometry with dual energy source of X-ray), handgrip strength (by Jamar® dynamometer), and the usual gait velocity according to the recommendations of the European Working Group on Sarcopenia in Older People. In both sarcopenics and non-sarcopenics elderly women, we evaluated the muscle function by knee extensors test (using an isokinetic dynamometer Byodex System 4 Pro®) at angular speeds of 60°/s and 180°/s) and also we evaluated the plasma concentrations of IL-6 and sTNFR1. Comparisons of muscle performance between groups were carried out using mixed factorial ANOVA with post hoc Bonferroni test; sTNFR1 and IL-6 variables were analyzed by applying Mann–Whitney U test. Results: Statistical differences were observed between groups regarding muscle power (P=0.01), total work adjusted to body weight (P=0.01) at a rate of 180°/s, and plasma levels of sTNFR1 (P=0.01). Conclusion: Sarcopenic elder women showed lower performance of the lower limbs, especially at a higher speed, predisposing these older women to greater vulnerability in functional activities that require agility and postural stability. Plasma levels of sTNFR1 were higher for non-sarcopenics elderlies. However, due to the observational nature of the study, it was impossible to infer causality among the variables surveyed. Keywords: sarcopenia, muscle performance, inflammatory mediators, aginghttps://www.dovepress.com/comparison-between-parameters-of-muscle-performance-and-inflammatory-b-peer-reviewed-article-CIAsarcopeniamuscle performanceinflammatory mediatorsaging. |
| spellingShingle | Lustosa LP Batista PP Pereira DS Pereira LS Scianni A Ribeiro-Samora GA Comparison between parameters of muscle performance and inflammatory biomarkers of non-sarcopenic and sarcopenic elderly women Clinical Interventions in Aging sarcopenia muscle performance inflammatory mediators aging. |
| title | Comparison between parameters of muscle performance and inflammatory biomarkers of non-sarcopenic and sarcopenic elderly women |
| title_full | Comparison between parameters of muscle performance and inflammatory biomarkers of non-sarcopenic and sarcopenic elderly women |
| title_fullStr | Comparison between parameters of muscle performance and inflammatory biomarkers of non-sarcopenic and sarcopenic elderly women |
| title_full_unstemmed | Comparison between parameters of muscle performance and inflammatory biomarkers of non-sarcopenic and sarcopenic elderly women |
| title_short | Comparison between parameters of muscle performance and inflammatory biomarkers of non-sarcopenic and sarcopenic elderly women |
| title_sort | comparison between parameters of muscle performance and inflammatory biomarkers of non sarcopenic and sarcopenic elderly women |
| topic | sarcopenia muscle performance inflammatory mediators aging. |
| url | https://www.dovepress.com/comparison-between-parameters-of-muscle-performance-and-inflammatory-b-peer-reviewed-article-CIA |
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