Advancement in Stem Cell Therapy for Ischemic Myocardial Cell: A systematic Review
Background: Cardiac muscle possesses a limited capacity to regenerate its tissue on its own. It is less likely to reverse the altered cardiac functioning to its normal physiological state after a major myocardial infarction. Stem cell transplantation provided a unique therapeutic approach in managin...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2018-06-01
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| Series: | International Journal of Hematology-Oncology and Stem Cell Research |
| Subjects: | |
| Online Access: | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/919 |
| _version_ | 1797716533887107072 |
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| author | Syeda Beenish Bareeqa Fazeela Bibi Syed Ijlal Ahmed Syeda Sana Samar |
| author_facet | Syeda Beenish Bareeqa Fazeela Bibi Syed Ijlal Ahmed Syeda Sana Samar |
| author_sort | Syeda Beenish Bareeqa |
| collection | DOAJ |
| description | Background: Cardiac muscle possesses a limited capacity to regenerate its tissue on its own. It is less likely to reverse the altered cardiac functioning to its normal physiological state after a major myocardial infarction. Stem cell transplantation provided a unique therapeutic approach in managing such injuries. There has been a substantial debate about the complexity, scope and medical application of stem cell transplantation in past few years.
Materials and Methods: An extensive review of medical literature was conducted to establish the consensus about the possible mechanism of cell renewal, associated complications and risks of failure of this technique. Twenty cases of mammalian animals and twenty-four cases of stem cell transplantation in human subjects were reviewed.
Results: Most common associated complication was re-stenosis of coronary artery. Few clinical trials reported the failure in improving cardiac functioning. The success rate of stem cell transplantation was remarkable in the literature related to experimental animal subjects.
Conclusion: It was concluded that renewal of the cardiac cell is a result of induction of angiogenesis and prolonged cell survival. This topic still requires an immense amount of research to fill the gap in adequate knowledge. |
| first_indexed | 2024-03-12T08:22:52Z |
| format | Article |
| id | doaj.art-9663cb466d174d7281cd34181584247c |
| institution | Directory Open Access Journal |
| issn | 2008-2207 |
| language | English |
| last_indexed | 2024-03-12T08:22:52Z |
| publishDate | 2018-06-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | International Journal of Hematology-Oncology and Stem Cell Research |
| spelling | doaj.art-9663cb466d174d7281cd34181584247c2023-09-02T18:18:20ZengTehran University of Medical SciencesInternational Journal of Hematology-Oncology and Stem Cell Research2008-22072018-06-0112410.18502/ijhoscr.v12i4.106Advancement in Stem Cell Therapy for Ischemic Myocardial Cell: A systematic ReviewSyeda Beenish Bareeqa0Fazeela Bibi1Syed Ijlal Ahmed2Syeda Sana Samar3Jinnah Medical and Dental College, Karachi, PakistanJinnah Medical and Dental College, Karachi, PakistanMedical Graduate, Liaquat National Medical College and Hospital, Karachi, PakistanJinnah Sindh Medical University, Karachi, PakistanBackground: Cardiac muscle possesses a limited capacity to regenerate its tissue on its own. It is less likely to reverse the altered cardiac functioning to its normal physiological state after a major myocardial infarction. Stem cell transplantation provided a unique therapeutic approach in managing such injuries. There has been a substantial debate about the complexity, scope and medical application of stem cell transplantation in past few years. Materials and Methods: An extensive review of medical literature was conducted to establish the consensus about the possible mechanism of cell renewal, associated complications and risks of failure of this technique. Twenty cases of mammalian animals and twenty-four cases of stem cell transplantation in human subjects were reviewed. Results: Most common associated complication was re-stenosis of coronary artery. Few clinical trials reported the failure in improving cardiac functioning. The success rate of stem cell transplantation was remarkable in the literature related to experimental animal subjects. Conclusion: It was concluded that renewal of the cardiac cell is a result of induction of angiogenesis and prolonged cell survival. This topic still requires an immense amount of research to fill the gap in adequate knowledge.https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/919Mesenchymal stem cells (MSCs), Myocardial infarction (MI), Cardiomyocytes, Hematopoietic stem cells (HSCs) |
| spellingShingle | Syeda Beenish Bareeqa Fazeela Bibi Syed Ijlal Ahmed Syeda Sana Samar Advancement in Stem Cell Therapy for Ischemic Myocardial Cell: A systematic Review International Journal of Hematology-Oncology and Stem Cell Research Mesenchymal stem cells (MSCs), Myocardial infarction (MI), Cardiomyocytes, Hematopoietic stem cells (HSCs) |
| title | Advancement in Stem Cell Therapy for Ischemic Myocardial Cell: A systematic Review |
| title_full | Advancement in Stem Cell Therapy for Ischemic Myocardial Cell: A systematic Review |
| title_fullStr | Advancement in Stem Cell Therapy for Ischemic Myocardial Cell: A systematic Review |
| title_full_unstemmed | Advancement in Stem Cell Therapy for Ischemic Myocardial Cell: A systematic Review |
| title_short | Advancement in Stem Cell Therapy for Ischemic Myocardial Cell: A systematic Review |
| title_sort | advancement in stem cell therapy for ischemic myocardial cell a systematic review |
| topic | Mesenchymal stem cells (MSCs), Myocardial infarction (MI), Cardiomyocytes, Hematopoietic stem cells (HSCs) |
| url | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/919 |
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