In-situ synthesized hydroxyapatite whiskers on 3D printed titanium cages enhanced osteointegration in a goat spinal fusion model
3D printed porous titanium cage is believed with physiology mechanical properties and biocompatibility for orthopedic usage. Typical split cage design with a grafting window and infilled bone graft has raised a lot of questions. In this research, a modified hydrothermal approach, employing chelated...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-09-01
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| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127523006858 |
| _version_ | 1797671478932537344 |
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| author | Xuan Pei Linnan Wang Lina Wu Haoyuan Lei Zhimou Zeng Lei Wang Changchun Zhou Xi Yang Yueming Song Yujiang Fan |
| author_facet | Xuan Pei Linnan Wang Lina Wu Haoyuan Lei Zhimou Zeng Lei Wang Changchun Zhou Xi Yang Yueming Song Yujiang Fan |
| author_sort | Xuan Pei |
| collection | DOAJ |
| description | 3D printed porous titanium cage is believed with physiology mechanical properties and biocompatibility for orthopedic usage. Typical split cage design with a grafting window and infilled bone graft has raised a lot of questions. In this research, a modified hydrothermal approach, employing chelated calcium to enhance the medium stability and increase the generated amount, is proposed to construct bioactive hydroxyapatite coating inside the porous structure of 3D printed porous titanium cage. The in vitro and transcriptomic results indicated the hydroxyapatite enhanced the cells physical sensing system, therefore enhanced the osteogenesis inside titanium/hydroxyapatite cage. The in vivo goat spinal fusion experiment indicated the integrative titanium/hydroxyapatite cage, compared with typical split cage/graft cage, showed better bone tissue ingrowth and spinal fusion ability. This research provides a promising hydroxyapatite coating strategy for complex porous structure and revealed the potential advantage of integrative titanium/hydroxyapatite intervertebral cage design. |
| first_indexed | 2024-03-11T21:16:08Z |
| format | Article |
| id | doaj.art-9665d8292b8f495a8b1ebd782ad02671 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-03-11T21:16:08Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-9665d8292b8f495a8b1ebd782ad026712023-09-29T04:43:37ZengElsevierMaterials & Design0264-12752023-09-01233112270In-situ synthesized hydroxyapatite whiskers on 3D printed titanium cages enhanced osteointegration in a goat spinal fusion modelXuan Pei0Linnan Wang1Lina Wu2Haoyuan Lei3Zhimou Zeng4Lei Wang5Changchun Zhou6Xi Yang7Yueming Song8Yujiang Fan9State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China; National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu 610064, ChinaOrthopedic Research Institution, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, ChinaNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu 610064, ChinaNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu 610064, ChinaOrthopedic Research Institution, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, ChinaOrthopedic Research Institution, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, ChinaNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu 610064, ChinaOrthopedic Research Institution, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, China; Corresponding authors.Orthopedic Research Institution, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, China; Corresponding authors.National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu 610064, China; Corresponding authors.3D printed porous titanium cage is believed with physiology mechanical properties and biocompatibility for orthopedic usage. Typical split cage design with a grafting window and infilled bone graft has raised a lot of questions. In this research, a modified hydrothermal approach, employing chelated calcium to enhance the medium stability and increase the generated amount, is proposed to construct bioactive hydroxyapatite coating inside the porous structure of 3D printed porous titanium cage. The in vitro and transcriptomic results indicated the hydroxyapatite enhanced the cells physical sensing system, therefore enhanced the osteogenesis inside titanium/hydroxyapatite cage. The in vivo goat spinal fusion experiment indicated the integrative titanium/hydroxyapatite cage, compared with typical split cage/graft cage, showed better bone tissue ingrowth and spinal fusion ability. This research provides a promising hydroxyapatite coating strategy for complex porous structure and revealed the potential advantage of integrative titanium/hydroxyapatite intervertebral cage design.http://www.sciencedirect.com/science/article/pii/S02641275230068583D printingHydroxyapatite coatingSpinal fusionOrthopedic implantHydrothermal process |
| spellingShingle | Xuan Pei Linnan Wang Lina Wu Haoyuan Lei Zhimou Zeng Lei Wang Changchun Zhou Xi Yang Yueming Song Yujiang Fan In-situ synthesized hydroxyapatite whiskers on 3D printed titanium cages enhanced osteointegration in a goat spinal fusion model Materials & Design 3D printing Hydroxyapatite coating Spinal fusion Orthopedic implant Hydrothermal process |
| title | In-situ synthesized hydroxyapatite whiskers on 3D printed titanium cages enhanced osteointegration in a goat spinal fusion model |
| title_full | In-situ synthesized hydroxyapatite whiskers on 3D printed titanium cages enhanced osteointegration in a goat spinal fusion model |
| title_fullStr | In-situ synthesized hydroxyapatite whiskers on 3D printed titanium cages enhanced osteointegration in a goat spinal fusion model |
| title_full_unstemmed | In-situ synthesized hydroxyapatite whiskers on 3D printed titanium cages enhanced osteointegration in a goat spinal fusion model |
| title_short | In-situ synthesized hydroxyapatite whiskers on 3D printed titanium cages enhanced osteointegration in a goat spinal fusion model |
| title_sort | in situ synthesized hydroxyapatite whiskers on 3d printed titanium cages enhanced osteointegration in a goat spinal fusion model |
| topic | 3D printing Hydroxyapatite coating Spinal fusion Orthopedic implant Hydrothermal process |
| url | http://www.sciencedirect.com/science/article/pii/S0264127523006858 |
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