Cytokine Based Immunotherapy for Cancer and Lymphoma: Biology, Challenges and Future Perspectives
Cytokines regulate both the innate and adaptive immune responses to cancer. Although antitumor activity has been seen for several cytokines in preclinical models, they have had limited success as single therapeutic agents in clinical trials of cancer immunotherapy. However, the possible combinations...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.872010/full |
| _version_ | 1811330407682015232 |
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| author | Suheil Albert Atallah-Yunes Michael J. Robertson |
| author_facet | Suheil Albert Atallah-Yunes Michael J. Robertson |
| author_sort | Suheil Albert Atallah-Yunes |
| collection | DOAJ |
| description | Cytokines regulate both the innate and adaptive immune responses to cancer. Although antitumor activity has been seen for several cytokines in preclinical models, they have had limited success as single therapeutic agents in clinical trials of cancer immunotherapy. However, the possible combinations of cytokines with other immune therapeutics and the advancement in genetic engineering, synthetic biology and cellular and immune therapy has led to the revival of interest in cytokines as anticancer agents. This article will review several immunostimulatory cytokines with anticancer activity, focusing on the those that have been studied in treatment of lymphoma and highlighting recent advances of potential clinical relevance. |
| first_indexed | 2024-04-13T16:00:56Z |
| format | Article |
| id | doaj.art-9665e646d9bd4f418bf2214f7aefdfe5 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T16:00:56Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-9665e646d9bd4f418bf2214f7aefdfe52022-12-22T02:40:32ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-04-011310.3389/fimmu.2022.872010872010Cytokine Based Immunotherapy for Cancer and Lymphoma: Biology, Challenges and Future PerspectivesSuheil Albert Atallah-YunesMichael J. RobertsonCytokines regulate both the innate and adaptive immune responses to cancer. Although antitumor activity has been seen for several cytokines in preclinical models, they have had limited success as single therapeutic agents in clinical trials of cancer immunotherapy. However, the possible combinations of cytokines with other immune therapeutics and the advancement in genetic engineering, synthetic biology and cellular and immune therapy has led to the revival of interest in cytokines as anticancer agents. This article will review several immunostimulatory cytokines with anticancer activity, focusing on the those that have been studied in treatment of lymphoma and highlighting recent advances of potential clinical relevance.https://www.frontiersin.org/articles/10.3389/fimmu.2022.872010/fullcytokinesimmunotherapyinterleukinscancerlymphoma |
| spellingShingle | Suheil Albert Atallah-Yunes Michael J. Robertson Cytokine Based Immunotherapy for Cancer and Lymphoma: Biology, Challenges and Future Perspectives Frontiers in Immunology cytokines immunotherapy interleukins cancer lymphoma |
| title | Cytokine Based Immunotherapy for Cancer and Lymphoma: Biology, Challenges and Future Perspectives |
| title_full | Cytokine Based Immunotherapy for Cancer and Lymphoma: Biology, Challenges and Future Perspectives |
| title_fullStr | Cytokine Based Immunotherapy for Cancer and Lymphoma: Biology, Challenges and Future Perspectives |
| title_full_unstemmed | Cytokine Based Immunotherapy for Cancer and Lymphoma: Biology, Challenges and Future Perspectives |
| title_short | Cytokine Based Immunotherapy for Cancer and Lymphoma: Biology, Challenges and Future Perspectives |
| title_sort | cytokine based immunotherapy for cancer and lymphoma biology challenges and future perspectives |
| topic | cytokines immunotherapy interleukins cancer lymphoma |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.872010/full |
| work_keys_str_mv | AT suheilalbertatallahyunes cytokinebasedimmunotherapyforcancerandlymphomabiologychallengesandfutureperspectives AT michaeljrobertson cytokinebasedimmunotherapyforcancerandlymphomabiologychallengesandfutureperspectives |