A Genome-Wide Association Study and Polygenic Risk Score Analysis of Posttraumatic Stress Disorder and Metabolic Syndrome in a South African Population

A Genome-Wide Association Study and Polygenic Risk Score Analysis of Posttraumatic Stress Disorder and Metabolic Syndrome in a South African Population

Posttraumatic stress disorder (PTSD) is a trauma-related disorder that frequently co-occurs with metabolic syndrome (MetS). MetS is characterized by obesity, dyslipidemia, and insulin resistance. To provide insight into these co-morbidities, we performed a genome-wide association study (GWAS) meta-a...

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Bibliographic Details
Main Authors: Patricia C. Swart, Leigh L. van den Heuvel, Cathryn M. Lewis, Soraya Seedat, Sian M. J. Hemmings
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Neuroscience
Subjects:
polygenic risk scores
GWAS
PTSD
metabolic syndrome
PARK2
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.677800/full

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