Functional and molecular characterization of PD1+ tumor-infiltrating lymphocytes from lung cancer patients

Functional and molecular characterization of PD1+ tumor-infiltrating lymphocytes from lung cancer patients

Antibody-mediated cancer immunotherapy targets inhibitory surface molecules, such as PD1, PD-L1, and CTLA-4, aiming to re-invigorate dysfunctional T cells. We purified and characterized tumor-infiltrating lymphocytes (TILs) and their patient-matched non-tumor counterparts from treatment-naïve NSCLC...

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Bibliographic Details
Main Authors: Jesse J. Lipp, Limei Wang, Haitang Yang, Feng Yao, Nathalie Harrer, Stefan Müller, Sabina Berezowska, Patrick Dorn, Thomas M. Marti, Ralph A. Schmid, Belazs Hegedüs, Abdallah Souabni, Sebastian Carotta, Mark A. Pearson, Wolfgang Sommergruber, Greg J. Kocher, Sean R.R. Hall
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:OncoImmunology
Subjects:
pd1
memory
tils
id3
gsk3β
Online Access:http://dx.doi.org/10.1080/2162402X.2021.2019466

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