E3 ligase RNF5 inhibits type I interferon response in herpes simplex virus keratitis through the STING/IRF3 signaling pathway

E3 ligase RNF5 inhibits type I interferon response in herpes simplex virus keratitis through the STING/IRF3 signaling pathway

Herpes simplex keratitis (HSK), caused by the herpes simplex virus 1 (HSV-1), is a major blinding disease in developed countries. HSV-1 can remain latent in the host for life and cannot be eradicated. The infection causes the secretion of various cytokines and aggregation of inflammatory cells. In t...

Full description

Bibliographic Details
Main Authors: Zhi Liu, Likun Xia
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Microbiology
Subjects:
HSV-1
herpes simplex keratitis
innate immunity
type I interferon
RNF5
STING
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.944101/full

Similar Items

Similar Items