An intracellular, non-oxidative factor activates in vitro chromatin fragmentation in pig sperm

An intracellular, non-oxidative factor activates in vitro chromatin fragmentation in pig sperm

Abstract Background In vitro incubation of epididymal and vas deferens sperm with Mn2+ induces Sperm Chromatin Fragmentation (SCF), a mechanism that causes double-stranded breaks in toroid-linker regions (TLRs). Whether this mechanism, thought to require the participation of topoisomerases and/or DN...

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Bibliographic Details
Main Authors: Estel Viñolas-Vergés, Marc Yeste, Ferran Garriga, Sergi Bonet, Yentel Mateo-Otero, Jordi Ribas-Maynou
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Biological Research
Subjects:
DNA
Ejaculated sperm
Fragmentation
Pig
Toroid-linker regions
Online Access:https://doi.org/10.1186/s40659-023-00467-w

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