Preclinical cerebral network connectivity evidence of deficits in mild white matter lesions
White matter lesions (WMLs) are notable for their high prevalence and have been demonstrated to be a potential neuroimaging biomarker of early diagnosis of Alzheimer’s disease. This study aimed to identify the brain functional and structural mechanisms underlying cognitive decline observed in mild W...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-02-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00027/full |
| _version_ | 1818470419966984192 |
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| author | Ying eLiang Ying eLiang Xuan eSun Shijun eXu Yaou eLiu Ruiwang eHuang Jianjun eJia Zhanjun eZhang Zhanjun eZhang |
| author_facet | Ying eLiang Ying eLiang Xuan eSun Shijun eXu Yaou eLiu Ruiwang eHuang Jianjun eJia Zhanjun eZhang Zhanjun eZhang |
| author_sort | Ying eLiang |
| collection | DOAJ |
| description | White matter lesions (WMLs) are notable for their high prevalence and have been demonstrated to be a potential neuroimaging biomarker of early diagnosis of Alzheimer’s disease. This study aimed to identify the brain functional and structural mechanisms underlying cognitive decline observed in mild WMLs. Multi-domain cognitive tests, as well as resting-state, diffusion tensor and structural images were obtained on 42 mild WMLs and 42 age/sex-matched healthy controls. For each participant, we examined the functional connectivity of three resting-state networks related to the changed cognitive domains: the default mode network (DMN) and the bilateral fronto-parietal network (FPN). We also performed voxel-based morphometry analysis to compare whole-brain gray matter volume, atlas-based quantification of the white matter tracts interconnecting the RSNs, and the relationship between functional connectivity and structural connectivity. We observed functional connectivity alterations in the DMN and the right FPN combined with related white matter integrity disruption in mild WMLs. However, no significant gray matter atrophy difference was found. Furthermore, the right precuneus functional connectivity in the DMN exhibited a significantly negative correlation with the memory test scores. Our study suggests that in mild WMLs, dysfunction of RSNs might be a consequence of decreased white matter structural connectivity, which further affects cognitive performance. |
| first_indexed | 2024-04-13T21:37:14Z |
| format | Article |
| id | doaj.art-966a598f75dc4eebb447e3e3348d33d6 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-13T21:37:14Z |
| publishDate | 2016-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-966a598f75dc4eebb447e3e3348d33d62022-12-22T02:28:55ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652016-02-01810.3389/fnagi.2016.00027179217Preclinical cerebral network connectivity evidence of deficits in mild white matter lesionsYing eLiang0Ying eLiang1Xuan eSun2Shijun eXu3Yaou eLiu4Ruiwang eHuang5Jianjun eJia6Zhanjun eZhang7Zhanjun eZhang8Beijing Normal UniversityBABRI Centre, Beijing Normal UniversityChinese PLA General HospitalChengdu University of Traditional Chinese MedicineCapital Medical UniversitySouth China Normal UniversityChinese PLA General HospitalBeijing Normal UniversityBABRI Centre, Beijing Normal UniversityWhite matter lesions (WMLs) are notable for their high prevalence and have been demonstrated to be a potential neuroimaging biomarker of early diagnosis of Alzheimer’s disease. This study aimed to identify the brain functional and structural mechanisms underlying cognitive decline observed in mild WMLs. Multi-domain cognitive tests, as well as resting-state, diffusion tensor and structural images were obtained on 42 mild WMLs and 42 age/sex-matched healthy controls. For each participant, we examined the functional connectivity of three resting-state networks related to the changed cognitive domains: the default mode network (DMN) and the bilateral fronto-parietal network (FPN). We also performed voxel-based morphometry analysis to compare whole-brain gray matter volume, atlas-based quantification of the white matter tracts interconnecting the RSNs, and the relationship between functional connectivity and structural connectivity. We observed functional connectivity alterations in the DMN and the right FPN combined with related white matter integrity disruption in mild WMLs. However, no significant gray matter atrophy difference was found. Furthermore, the right precuneus functional connectivity in the DMN exhibited a significantly negative correlation with the memory test scores. Our study suggests that in mild WMLs, dysfunction of RSNs might be a consequence of decreased white matter structural connectivity, which further affects cognitive performance.http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00027/fullfunctional connectivitycognitive impairmentsresting-state networksWhite Matter Integritymild white matter lesions |
| spellingShingle | Ying eLiang Ying eLiang Xuan eSun Shijun eXu Yaou eLiu Ruiwang eHuang Jianjun eJia Zhanjun eZhang Zhanjun eZhang Preclinical cerebral network connectivity evidence of deficits in mild white matter lesions Frontiers in Aging Neuroscience functional connectivity cognitive impairments resting-state networks White Matter Integrity mild white matter lesions |
| title | Preclinical cerebral network connectivity evidence of deficits in mild white matter lesions |
| title_full | Preclinical cerebral network connectivity evidence of deficits in mild white matter lesions |
| title_fullStr | Preclinical cerebral network connectivity evidence of deficits in mild white matter lesions |
| title_full_unstemmed | Preclinical cerebral network connectivity evidence of deficits in mild white matter lesions |
| title_short | Preclinical cerebral network connectivity evidence of deficits in mild white matter lesions |
| title_sort | preclinical cerebral network connectivity evidence of deficits in mild white matter lesions |
| topic | functional connectivity cognitive impairments resting-state networks White Matter Integrity mild white matter lesions |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00027/full |
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