Composition of PM affects acute vascular inflammatory and coagulative markers - the RAPTES project.
Exposure to ambient particulate matter (PM) has been associated with adverse cardiovascular effects in epidemiological studies. Current knowledge of independent effects of individual PM characteristics remains limited.Using a semi-experimental design we investigated which PM characteristics were con...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3596332?pdf=render |
| _version_ | 1818438085116952576 |
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| author | Maciej Strak Gerard Hoek Krystal J Godri Ilse Gosens Ian S Mudway René van Oerle Henri M H Spronk Flemming R Cassee Erik Lebret Frank J Kelly Roy M Harrison Bert Brunekreef Maaike Steenhof Nicole A H Janssen |
| author_facet | Maciej Strak Gerard Hoek Krystal J Godri Ilse Gosens Ian S Mudway René van Oerle Henri M H Spronk Flemming R Cassee Erik Lebret Frank J Kelly Roy M Harrison Bert Brunekreef Maaike Steenhof Nicole A H Janssen |
| author_sort | Maciej Strak |
| collection | DOAJ |
| description | Exposure to ambient particulate matter (PM) has been associated with adverse cardiovascular effects in epidemiological studies. Current knowledge of independent effects of individual PM characteristics remains limited.Using a semi-experimental design we investigated which PM characteristics were consistently associated with blood biomarkers believed to be predictive of the risk of cardiovascular events. We exposed healthy adult volunteers at 5 different locations chosen to provide PM exposure contrasts with reduced correlations among PM characteristics. Each of the 31 volunteers was exposed for 5 h, exercising intermittently, 3-7 times at different sites from March to October 2009. Extensive on-site exposure characterization included measurements of PM mass and number concentration, elemental- (EC) and organic carbon (OC), trace metals, sulfate, nitrate, and PM oxidative potential (OP). Before and 2 h and 18 h after exposure we measured acute vascular blood biomarkers - C-reactive protein, fibrinogen, platelet counts, von Willebrand Factor, and tissue plasminogen activator/plasminogen activator inhibitor-1 complex. We used two-pollutant models to assess which PM characteristics were most consistently associated with the measured biomarkers.We found OC, nitrate and sulfate to be most consistently associated with different biomarkers of acute cardiovascular risk. Associations with PM mass concentrations and OP were less consistent, whereas other measured components of the air pollution mixture, including PNC, EC, trace metals and NO2, were not associated with the biomarkers after adjusting for other pollutants. |
| first_indexed | 2024-12-14T17:34:57Z |
| format | Article |
| id | doaj.art-966c5fcd840b42eabd38ca6e456eed4a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T17:34:57Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-966c5fcd840b42eabd38ca6e456eed4a2022-12-21T22:53:01ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0183e5894410.1371/journal.pone.0058944Composition of PM affects acute vascular inflammatory and coagulative markers - the RAPTES project.Maciej StrakGerard HoekKrystal J GodriIlse GosensIan S MudwayRené van OerleHenri M H SpronkFlemming R CasseeErik LebretFrank J KellyRoy M HarrisonBert BrunekreefMaaike SteenhofNicole A H JanssenExposure to ambient particulate matter (PM) has been associated with adverse cardiovascular effects in epidemiological studies. Current knowledge of independent effects of individual PM characteristics remains limited.Using a semi-experimental design we investigated which PM characteristics were consistently associated with blood biomarkers believed to be predictive of the risk of cardiovascular events. We exposed healthy adult volunteers at 5 different locations chosen to provide PM exposure contrasts with reduced correlations among PM characteristics. Each of the 31 volunteers was exposed for 5 h, exercising intermittently, 3-7 times at different sites from March to October 2009. Extensive on-site exposure characterization included measurements of PM mass and number concentration, elemental- (EC) and organic carbon (OC), trace metals, sulfate, nitrate, and PM oxidative potential (OP). Before and 2 h and 18 h after exposure we measured acute vascular blood biomarkers - C-reactive protein, fibrinogen, platelet counts, von Willebrand Factor, and tissue plasminogen activator/plasminogen activator inhibitor-1 complex. We used two-pollutant models to assess which PM characteristics were most consistently associated with the measured biomarkers.We found OC, nitrate and sulfate to be most consistently associated with different biomarkers of acute cardiovascular risk. Associations with PM mass concentrations and OP were less consistent, whereas other measured components of the air pollution mixture, including PNC, EC, trace metals and NO2, were not associated with the biomarkers after adjusting for other pollutants.http://europepmc.org/articles/PMC3596332?pdf=render |
| spellingShingle | Maciej Strak Gerard Hoek Krystal J Godri Ilse Gosens Ian S Mudway René van Oerle Henri M H Spronk Flemming R Cassee Erik Lebret Frank J Kelly Roy M Harrison Bert Brunekreef Maaike Steenhof Nicole A H Janssen Composition of PM affects acute vascular inflammatory and coagulative markers - the RAPTES project. PLoS ONE |
| title | Composition of PM affects acute vascular inflammatory and coagulative markers - the RAPTES project. |
| title_full | Composition of PM affects acute vascular inflammatory and coagulative markers - the RAPTES project. |
| title_fullStr | Composition of PM affects acute vascular inflammatory and coagulative markers - the RAPTES project. |
| title_full_unstemmed | Composition of PM affects acute vascular inflammatory and coagulative markers - the RAPTES project. |
| title_short | Composition of PM affects acute vascular inflammatory and coagulative markers - the RAPTES project. |
| title_sort | composition of pm affects acute vascular inflammatory and coagulative markers the raptes project |
| url | http://europepmc.org/articles/PMC3596332?pdf=render |
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