Theoretical and experimental study on the detection limit of the micro-ring resonator based ultrasound point detectors
Combining the diffusive laser excitation and the photoacoustic signals detection, photoacoustic computed tomography (PACT) is uniquely suited for deep tissue imaging. A diffraction-limited ultrasound point detector is highly desirable for maximizing the spatial resolution and the field-of-view of th...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
|
| Series: | Photoacoustics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213597923001271 |
| _version_ | 1797398575823454208 |
|---|---|
| author | Youngseop Lee Qiangzhou Rong Ki-Hee Song David A. Czaplewski Hao F. Zhang Junjie Yao Cheng Sun |
| author_facet | Youngseop Lee Qiangzhou Rong Ki-Hee Song David A. Czaplewski Hao F. Zhang Junjie Yao Cheng Sun |
| author_sort | Youngseop Lee |
| collection | DOAJ |
| description | Combining the diffusive laser excitation and the photoacoustic signals detection, photoacoustic computed tomography (PACT) is uniquely suited for deep tissue imaging. A diffraction-limited ultrasound point detector is highly desirable for maximizing the spatial resolution and the field-of-view of the reconstructed volumetric images. Among all the available ultrasound detectors, micro-ring resonator (MRR) based ultrasound detectors offer the lowest area-normalized limit of detection (nLOD) in a miniature form-factor, making it an ideal candidate as an ultrasound point detector. However, despite their wide adoption for photoacoustic imaging, the underlying signal transduction process has not been systematically studied yet. Here we report a comprehensive theoretical model capturing the transduction of incident acoustic signals into digital data, and the associated noise propagation process, using experimentally calibrated key process parameters. The theoretical model quantifies the signal-to-noise ratio (SNR) and the nLOD under the influence of the key process variables, including the quality factor (Q-factor) of the MRR and the driving wavelength. While asserting the need for higher Q-factors, the theoretical model further quantifies the optimal driving wavelength for optimizing the nLOD. Given the MRR with a Q-factor of 1 × 105, the theoretical model predicts an optimal SNR of 30.1 dB and a corresponding nLOD of 3.75 × 10−2 mPa mm2/Hz1/2, which are in good agreement with the experimental measurements of 31.0 dB and 3.39 × 10−2 mPa mm2/Hz1/2, respectively. The reported theoretical model can be used in guiding the optimization of MRR-based ultrasonic detectors and PA experimental conditions, in attaining higher imaging resolution and contrast. The optimized operating condition has been further validated by performing PACT imaging of a human hair phantom. |
| first_indexed | 2024-03-09T01:27:28Z |
| format | Article |
| id | doaj.art-966c966f977349c0bfd7afda22499463 |
| institution | Directory Open Access Journal |
| issn | 2213-5979 |
| language | English |
| last_indexed | 2024-03-09T01:27:28Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photoacoustics |
| spelling | doaj.art-966c966f977349c0bfd7afda224994632023-12-10T06:16:06ZengElsevierPhotoacoustics2213-59792023-12-0134100574Theoretical and experimental study on the detection limit of the micro-ring resonator based ultrasound point detectorsYoungseop Lee0Qiangzhou Rong1Ki-Hee Song2David A. Czaplewski3Hao F. Zhang4Junjie Yao5Cheng Sun6Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA; Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USADepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USADepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USACenter for Nanoscale Materials, Argonne National Laboratory, Argonne, IL 60439, USADepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USACo-corresponding author.; Department of Biomedical Engineering, Duke University, Durham, NC 27708, USACorresponding author.; Department of Mechanical Engineering, Northwestern University, Evanston IL 60208, USACombining the diffusive laser excitation and the photoacoustic signals detection, photoacoustic computed tomography (PACT) is uniquely suited for deep tissue imaging. A diffraction-limited ultrasound point detector is highly desirable for maximizing the spatial resolution and the field-of-view of the reconstructed volumetric images. Among all the available ultrasound detectors, micro-ring resonator (MRR) based ultrasound detectors offer the lowest area-normalized limit of detection (nLOD) in a miniature form-factor, making it an ideal candidate as an ultrasound point detector. However, despite their wide adoption for photoacoustic imaging, the underlying signal transduction process has not been systematically studied yet. Here we report a comprehensive theoretical model capturing the transduction of incident acoustic signals into digital data, and the associated noise propagation process, using experimentally calibrated key process parameters. The theoretical model quantifies the signal-to-noise ratio (SNR) and the nLOD under the influence of the key process variables, including the quality factor (Q-factor) of the MRR and the driving wavelength. While asserting the need for higher Q-factors, the theoretical model further quantifies the optimal driving wavelength for optimizing the nLOD. Given the MRR with a Q-factor of 1 × 105, the theoretical model predicts an optimal SNR of 30.1 dB and a corresponding nLOD of 3.75 × 10−2 mPa mm2/Hz1/2, which are in good agreement with the experimental measurements of 31.0 dB and 3.39 × 10−2 mPa mm2/Hz1/2, respectively. The reported theoretical model can be used in guiding the optimization of MRR-based ultrasonic detectors and PA experimental conditions, in attaining higher imaging resolution and contrast. The optimized operating condition has been further validated by performing PACT imaging of a human hair phantom.http://www.sciencedirect.com/science/article/pii/S2213597923001271Polymer micro-ring resonatorUltrasound detectorPhotoacoustic imagingPhotoacoustic computed tomography |
| spellingShingle | Youngseop Lee Qiangzhou Rong Ki-Hee Song David A. Czaplewski Hao F. Zhang Junjie Yao Cheng Sun Theoretical and experimental study on the detection limit of the micro-ring resonator based ultrasound point detectors Photoacoustics Polymer micro-ring resonator Ultrasound detector Photoacoustic imaging Photoacoustic computed tomography |
| title | Theoretical and experimental study on the detection limit of the micro-ring resonator based ultrasound point detectors |
| title_full | Theoretical and experimental study on the detection limit of the micro-ring resonator based ultrasound point detectors |
| title_fullStr | Theoretical and experimental study on the detection limit of the micro-ring resonator based ultrasound point detectors |
| title_full_unstemmed | Theoretical and experimental study on the detection limit of the micro-ring resonator based ultrasound point detectors |
| title_short | Theoretical and experimental study on the detection limit of the micro-ring resonator based ultrasound point detectors |
| title_sort | theoretical and experimental study on the detection limit of the micro ring resonator based ultrasound point detectors |
| topic | Polymer micro-ring resonator Ultrasound detector Photoacoustic imaging Photoacoustic computed tomography |
| url | http://www.sciencedirect.com/science/article/pii/S2213597923001271 |
| work_keys_str_mv | AT youngseoplee theoreticalandexperimentalstudyonthedetectionlimitofthemicroringresonatorbasedultrasoundpointdetectors AT qiangzhourong theoreticalandexperimentalstudyonthedetectionlimitofthemicroringresonatorbasedultrasoundpointdetectors AT kiheesong theoreticalandexperimentalstudyonthedetectionlimitofthemicroringresonatorbasedultrasoundpointdetectors AT davidaczaplewski theoreticalandexperimentalstudyonthedetectionlimitofthemicroringresonatorbasedultrasoundpointdetectors AT haofzhang theoreticalandexperimentalstudyonthedetectionlimitofthemicroringresonatorbasedultrasoundpointdetectors AT junjieyao theoreticalandexperimentalstudyonthedetectionlimitofthemicroringresonatorbasedultrasoundpointdetectors AT chengsun theoreticalandexperimentalstudyonthedetectionlimitofthemicroringresonatorbasedultrasoundpointdetectors |