Understanding the Effects of Anesthesia on Cortical Electrophysiological Recordings: A Scoping Review
General anesthesia in animal experiments is an ethical must and is required for all the procedures that are likely to cause more than slight or momentary pain. As anesthetics are known to deeply affect experimental findings, including electrophysiological recordings of brain activity, understanding...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/3/1286 |
| _version_ | 1797406447636578304 |
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| author | Vincenzo Sorrenti Claudia Cecchetto Marta Maschietto Stefano Fortinguerra Alessandro Buriani Stefano Vassanelli |
| author_facet | Vincenzo Sorrenti Claudia Cecchetto Marta Maschietto Stefano Fortinguerra Alessandro Buriani Stefano Vassanelli |
| author_sort | Vincenzo Sorrenti |
| collection | DOAJ |
| description | General anesthesia in animal experiments is an ethical must and is required for all the procedures that are likely to cause more than slight or momentary pain. As anesthetics are known to deeply affect experimental findings, including electrophysiological recordings of brain activity, understanding their mechanism of action is of paramount importance. It is widely recognized that the depth and type of anesthesia introduce significant bias in electrophysiological measurements by affecting the shape of both spontaneous and evoked signals, e.g., modifying their latency and relative amplitude. Therefore, for a given experimental protocol, it is relevant to identify the appropriate anesthetic, to minimize the impact on neuronal circuits and related signals under investigation. This review focuses on the effect of different anesthetics on cortical electrical recordings, examining their molecular mechanisms of action, their influence on neuronal microcircuits and, consequently, their impact on cortical measurements. |
| first_indexed | 2024-03-09T03:26:36Z |
| format | Article |
| id | doaj.art-966d7fdbd15c449697dabcc110a5b32f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T03:26:36Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-966d7fdbd15c449697dabcc110a5b32f2023-12-03T15:02:32ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-01-01223128610.3390/ijms22031286Understanding the Effects of Anesthesia on Cortical Electrophysiological Recordings: A Scoping ReviewVincenzo Sorrenti0Claudia Cecchetto1Marta Maschietto2Stefano Fortinguerra3Alessandro Buriani4Stefano Vassanelli5Department of Pharmaceutical & Pharmacological Sciences, University of Padova, 35131 Padova, ItalyOptical Neuroimaging Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa 904-0495, JapanDepartment of Biomedical Sciences, Section of Physiology, University of Padova, via F. Marzolo 3, 35131 Padova, ItalyIRCCS SDN, 80143 Napoli, ItalyMaria Paola Belloni Center for Personalized Medicine, Data Medica Group (Synlab Limited), 35100 Padova, ItalyDepartment of Biomedical Sciences, Section of Physiology, University of Padova, via F. Marzolo 3, 35131 Padova, ItalyGeneral anesthesia in animal experiments is an ethical must and is required for all the procedures that are likely to cause more than slight or momentary pain. As anesthetics are known to deeply affect experimental findings, including electrophysiological recordings of brain activity, understanding their mechanism of action is of paramount importance. It is widely recognized that the depth and type of anesthesia introduce significant bias in electrophysiological measurements by affecting the shape of both spontaneous and evoked signals, e.g., modifying their latency and relative amplitude. Therefore, for a given experimental protocol, it is relevant to identify the appropriate anesthetic, to minimize the impact on neuronal circuits and related signals under investigation. This review focuses on the effect of different anesthetics on cortical electrical recordings, examining their molecular mechanisms of action, their influence on neuronal microcircuits and, consequently, their impact on cortical measurements.https://www.mdpi.com/1422-0067/22/3/1286anesthesiasevofluranepropofolketaminecortical recordingselectrophysiology |
| spellingShingle | Vincenzo Sorrenti Claudia Cecchetto Marta Maschietto Stefano Fortinguerra Alessandro Buriani Stefano Vassanelli Understanding the Effects of Anesthesia on Cortical Electrophysiological Recordings: A Scoping Review International Journal of Molecular Sciences anesthesia sevoflurane propofol ketamine cortical recordings electrophysiology |
| title | Understanding the Effects of Anesthesia on Cortical Electrophysiological Recordings: A Scoping Review |
| title_full | Understanding the Effects of Anesthesia on Cortical Electrophysiological Recordings: A Scoping Review |
| title_fullStr | Understanding the Effects of Anesthesia on Cortical Electrophysiological Recordings: A Scoping Review |
| title_full_unstemmed | Understanding the Effects of Anesthesia on Cortical Electrophysiological Recordings: A Scoping Review |
| title_short | Understanding the Effects of Anesthesia on Cortical Electrophysiological Recordings: A Scoping Review |
| title_sort | understanding the effects of anesthesia on cortical electrophysiological recordings a scoping review |
| topic | anesthesia sevoflurane propofol ketamine cortical recordings electrophysiology |
| url | https://www.mdpi.com/1422-0067/22/3/1286 |
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