Case Report: Complex Congenital Brain Anomaly in a BBxHF Calf–Clinical Signs, Magnetic Resonance Imaging, and Pathological Findings
This case report describes the clinical signs, magnetic resonance imaging (MRI) findings and associated (histo)pathological findings in a crossbred Belgian Blue calf with congenital complex brain anomaly. The calf was presented with non-progressive signs (including cerebellar ataxia) since it was bo...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-09-01
|
| Series: | Frontiers in Veterinary Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2021.700527/full |
| _version_ | 1819131562342481920 |
|---|---|
| author | Neeltje J. Veenema Koen M. Santifort Nienke W. Kuijpers Anne Seijger Peter R. Hut |
| author_facet | Neeltje J. Veenema Koen M. Santifort Nienke W. Kuijpers Anne Seijger Peter R. Hut |
| author_sort | Neeltje J. Veenema |
| collection | DOAJ |
| description | This case report describes the clinical signs, magnetic resonance imaging (MRI) findings and associated (histo)pathological findings in a crossbred Belgian Blue calf with congenital complex brain anomaly. The calf was presented with non-progressive signs (including cerebellar ataxia) since it was born, suggestive of a multifocal intracranial lesion. A congenital anomaly was suspected and after hematology, biochemistry, serology, and cerebrospinal fluid analysis, a magnetic resonance imaging study was performed. The following suspected abnormalities were the principal changes identified: severe hydrocephalus, porencephaly, suspected partial corpus callosum agenesis (CCA), and increased fluid signal between the folia of the cerebellum. Post-mortem examination predominately reflected the MRI findings. The origin for these malformations could not be identified and there was no evidence of a causative infectious agent. Corpus callosum abnormalities have been reported in bovids before and have been linked to bovine viral diarrhea virus (BVDV) infections, as have several other central nervous system anomalies in this species. In this case, BVDV was deemed an unlikely causative agent based on serology test results and lack of typical histopathological signs. The etiology of the congenital anomaly present in this bovine calf remains unknown. |
| first_indexed | 2024-12-22T09:17:29Z |
| format | Article |
| id | doaj.art-966f9b47380149f88f80cfd4c6b26033 |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-12-22T09:17:29Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-966f9b47380149f88f80cfd4c6b260332022-12-21T18:31:17ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692021-09-01810.3389/fvets.2021.700527700527Case Report: Complex Congenital Brain Anomaly in a BBxHF Calf–Clinical Signs, Magnetic Resonance Imaging, and Pathological FindingsNeeltje J. Veenema0Koen M. Santifort1Nienke W. Kuijpers2Anne Seijger3Peter R. Hut4Department of Population Health Sciences, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, NetherlandsEvidensia Animal Hospital Arnhem, Arnhem, NetherlandsDepartment of Diagnostic Imaging, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, NetherlandsDepartment of Population Health Sciences, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, NetherlandsDepartment of Population Health Sciences, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, NetherlandsThis case report describes the clinical signs, magnetic resonance imaging (MRI) findings and associated (histo)pathological findings in a crossbred Belgian Blue calf with congenital complex brain anomaly. The calf was presented with non-progressive signs (including cerebellar ataxia) since it was born, suggestive of a multifocal intracranial lesion. A congenital anomaly was suspected and after hematology, biochemistry, serology, and cerebrospinal fluid analysis, a magnetic resonance imaging study was performed. The following suspected abnormalities were the principal changes identified: severe hydrocephalus, porencephaly, suspected partial corpus callosum agenesis (CCA), and increased fluid signal between the folia of the cerebellum. Post-mortem examination predominately reflected the MRI findings. The origin for these malformations could not be identified and there was no evidence of a causative infectious agent. Corpus callosum abnormalities have been reported in bovids before and have been linked to bovine viral diarrhea virus (BVDV) infections, as have several other central nervous system anomalies in this species. In this case, BVDV was deemed an unlikely causative agent based on serology test results and lack of typical histopathological signs. The etiology of the congenital anomaly present in this bovine calf remains unknown.https://www.frontiersin.org/articles/10.3389/fvets.2021.700527/fullbovidcerebellar ataxiacorpus callosum agenesishydrocephalusporencephaly |
| spellingShingle | Neeltje J. Veenema Koen M. Santifort Nienke W. Kuijpers Anne Seijger Peter R. Hut Case Report: Complex Congenital Brain Anomaly in a BBxHF Calf–Clinical Signs, Magnetic Resonance Imaging, and Pathological Findings Frontiers in Veterinary Science bovid cerebellar ataxia corpus callosum agenesis hydrocephalus porencephaly |
| title | Case Report: Complex Congenital Brain Anomaly in a BBxHF Calf–Clinical Signs, Magnetic Resonance Imaging, and Pathological Findings |
| title_full | Case Report: Complex Congenital Brain Anomaly in a BBxHF Calf–Clinical Signs, Magnetic Resonance Imaging, and Pathological Findings |
| title_fullStr | Case Report: Complex Congenital Brain Anomaly in a BBxHF Calf–Clinical Signs, Magnetic Resonance Imaging, and Pathological Findings |
| title_full_unstemmed | Case Report: Complex Congenital Brain Anomaly in a BBxHF Calf–Clinical Signs, Magnetic Resonance Imaging, and Pathological Findings |
| title_short | Case Report: Complex Congenital Brain Anomaly in a BBxHF Calf–Clinical Signs, Magnetic Resonance Imaging, and Pathological Findings |
| title_sort | case report complex congenital brain anomaly in a bbxhf calf clinical signs magnetic resonance imaging and pathological findings |
| topic | bovid cerebellar ataxia corpus callosum agenesis hydrocephalus porencephaly |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2021.700527/full |
| work_keys_str_mv | AT neeltjejveenema casereportcomplexcongenitalbrainanomalyinabbxhfcalfclinicalsignsmagneticresonanceimagingandpathologicalfindings AT koenmsantifort casereportcomplexcongenitalbrainanomalyinabbxhfcalfclinicalsignsmagneticresonanceimagingandpathologicalfindings AT nienkewkuijpers casereportcomplexcongenitalbrainanomalyinabbxhfcalfclinicalsignsmagneticresonanceimagingandpathologicalfindings AT anneseijger casereportcomplexcongenitalbrainanomalyinabbxhfcalfclinicalsignsmagneticresonanceimagingandpathologicalfindings AT peterrhut casereportcomplexcongenitalbrainanomalyinabbxhfcalfclinicalsignsmagneticresonanceimagingandpathologicalfindings |