Sequencing of 19,219 exomes identifies a low-frequency variant in FKBP5 promoter predisposing to high myopia in a Han Chinese population

Sequencing of 19,219 exomes identifies a low-frequency variant in FKBP5 promoter predisposing to high myopia in a Han Chinese population

Summary: High myopia (HM) is one of the leading causes of visual impairment and blindness worldwide. Here, we report a whole-exome sequencing (WES) study in 9,613 HM cases and 9,606 controls of Han Chinese ancestry to pinpoint HM-associated risk variants. Single-variant association analysis identifi...

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Bibliographic Details
Main Authors: Jianzhong Su, Jian Yuan, Liangde Xu, Shilai Xing, Mengru Sun, Yinghao Yao, Yunlong Ma, Fukun Chen, Longda Jiang, Kai Li, Xiangyi Yu, Zhengbo Xue, Yaru Zhang, Dandan Fan, Ji Zhang, Hui Liu, Xinting Liu, Guosi Zhang, Hong Wang, Meng Zhou, Fan Lyu, Gang An, Xiaoguang Yu, Yuanchao Xue, Jian Yang, Jia Qu
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Cell Reports
Subjects:
CP: Genomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723005211

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