Long-term osseointegration of laser-ablated hearing implants in sheep cranial bone
Osseointegration, the ability for an implant to be anchored in bone tissue with direct bone-implant contact and allowing for continuous adaptive remodelling, is clinically used in different reconstructive fields, such as dentistry, orthopedics and otology. The latter uses a bone conducting sound pro...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-08-01
|
| Series: | Frontiers in Surgery |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2022.885964/full |
| _version_ | 1811188593111072768 |
|---|---|
| author | Martin Lars Johansson Martin Lars Johansson Furqan A. Shah Måns Eeg-Olofsson Måns Eeg-Olofsson Peter Monksfield Peter Thomsen Anders Palmquist |
| author_facet | Martin Lars Johansson Martin Lars Johansson Furqan A. Shah Måns Eeg-Olofsson Måns Eeg-Olofsson Peter Monksfield Peter Thomsen Anders Palmquist |
| author_sort | Martin Lars Johansson |
| collection | DOAJ |
| description | Osseointegration, the ability for an implant to be anchored in bone tissue with direct bone-implant contact and allowing for continuous adaptive remodelling, is clinically used in different reconstructive fields, such as dentistry, orthopedics and otology. The latter uses a bone conducting sound processor connected to a skin-penetrating abutment that is mounted on a titanium implant placed in the temporal bone, thereby acting as a path for transmission of the vibrations generated by the sound processor. The success of the treatment relies on bone healing and osseointegration, which could be improved by surface modifications. The aim of this study was to evaluate the long-term osseointegration in a sheep skull model and compare a laser-ablated implant surface with a machined implant. Commercially available 4 mm titanium implants, either with a machined (Wide Ponto) or a laser-ablated surface (Ponto BHX, Oticon Medical, Sweden), were used in the current study. The surfaces were evaluated by scanning electron microscopy. The implantation was performed with a full soft tissue flap and the osteotomy was prepared using the MIPS drill kit (Oticon Medical, Sweden) prior to installation of the implants in the frontal bone of eight female sheep. After five months, biopsies including the implant and surrounding bone tissue obtained, processed and analysed using histology, histomorphometry, scanning electron microscopy and Raman spectroscopy. The animals healed well, without signs of adverse events. Histomorphometry showed a large amount of bone tissue around both implant types, with 75% of the threaded area occupied by bone for both implant types. A large amount of bone-implant contact was observed for both implant types, with 67%–71% of the surface covered by bone. Both implant types were surrounded by mature remodelled lamellar bone with high mineral content, corroborating the histological observations. The current results show that the laser-ablated surface induces healing similar to the well-known clinically used machined surface in ovine cranial bone. In conclusion, the present long-term experimental results indicate that a laser-ablated implant performs equally well as a clinically used implant with a machined surface. This, together with previously reported, improved early biomechanical anchorage, suggests future, safe and efficient clinical potential. |
| first_indexed | 2024-04-11T14:22:17Z |
| format | Article |
| id | doaj.art-96706baca8fd4535a29ac3b83c8b8cdf |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-04-11T14:22:17Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-96706baca8fd4535a29ac3b83c8b8cdf2022-12-22T04:19:02ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2022-08-01910.3389/fsurg.2022.885964885964Long-term osseointegration of laser-ablated hearing implants in sheep cranial boneMartin Lars Johansson0Martin Lars Johansson1Furqan A. Shah2Måns Eeg-Olofsson3Måns Eeg-Olofsson4Peter Monksfield5Peter Thomsen6Anders Palmquist7Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenResearch and Technology, Oticon Medical AB, Askim, SwedenDepartment of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenDepartment of Otorhinolaryngology Head and Neck Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenDepartment of Otorhinolaryngology, Head and Neck Surgery, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, SwedenENT Department, University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital Birmingham, Birmingham, United KingdomDepartment of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenDepartment of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenOsseointegration, the ability for an implant to be anchored in bone tissue with direct bone-implant contact and allowing for continuous adaptive remodelling, is clinically used in different reconstructive fields, such as dentistry, orthopedics and otology. The latter uses a bone conducting sound processor connected to a skin-penetrating abutment that is mounted on a titanium implant placed in the temporal bone, thereby acting as a path for transmission of the vibrations generated by the sound processor. The success of the treatment relies on bone healing and osseointegration, which could be improved by surface modifications. The aim of this study was to evaluate the long-term osseointegration in a sheep skull model and compare a laser-ablated implant surface with a machined implant. Commercially available 4 mm titanium implants, either with a machined (Wide Ponto) or a laser-ablated surface (Ponto BHX, Oticon Medical, Sweden), were used in the current study. The surfaces were evaluated by scanning electron microscopy. The implantation was performed with a full soft tissue flap and the osteotomy was prepared using the MIPS drill kit (Oticon Medical, Sweden) prior to installation of the implants in the frontal bone of eight female sheep. After five months, biopsies including the implant and surrounding bone tissue obtained, processed and analysed using histology, histomorphometry, scanning electron microscopy and Raman spectroscopy. The animals healed well, without signs of adverse events. Histomorphometry showed a large amount of bone tissue around both implant types, with 75% of the threaded area occupied by bone for both implant types. A large amount of bone-implant contact was observed for both implant types, with 67%–71% of the surface covered by bone. Both implant types were surrounded by mature remodelled lamellar bone with high mineral content, corroborating the histological observations. The current results show that the laser-ablated surface induces healing similar to the well-known clinically used machined surface in ovine cranial bone. In conclusion, the present long-term experimental results indicate that a laser-ablated implant performs equally well as a clinically used implant with a machined surface. This, together with previously reported, improved early biomechanical anchorage, suggests future, safe and efficient clinical potential.https://www.frontiersin.org/articles/10.3389/fsurg.2022.885964/fullosseointegrationbone anchored hearingtitanium implantin vivolasersurface properties |
| spellingShingle | Martin Lars Johansson Martin Lars Johansson Furqan A. Shah Måns Eeg-Olofsson Måns Eeg-Olofsson Peter Monksfield Peter Thomsen Anders Palmquist Long-term osseointegration of laser-ablated hearing implants in sheep cranial bone Frontiers in Surgery osseointegration bone anchored hearing titanium implant in vivo laser surface properties |
| title | Long-term osseointegration of laser-ablated hearing implants in sheep cranial bone |
| title_full | Long-term osseointegration of laser-ablated hearing implants in sheep cranial bone |
| title_fullStr | Long-term osseointegration of laser-ablated hearing implants in sheep cranial bone |
| title_full_unstemmed | Long-term osseointegration of laser-ablated hearing implants in sheep cranial bone |
| title_short | Long-term osseointegration of laser-ablated hearing implants in sheep cranial bone |
| title_sort | long term osseointegration of laser ablated hearing implants in sheep cranial bone |
| topic | osseointegration bone anchored hearing titanium implant in vivo laser surface properties |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2022.885964/full |
| work_keys_str_mv | AT martinlarsjohansson longtermosseointegrationoflaserablatedhearingimplantsinsheepcranialbone AT martinlarsjohansson longtermosseointegrationoflaserablatedhearingimplantsinsheepcranialbone AT furqanashah longtermosseointegrationoflaserablatedhearingimplantsinsheepcranialbone AT manseegolofsson longtermosseointegrationoflaserablatedhearingimplantsinsheepcranialbone AT manseegolofsson longtermosseointegrationoflaserablatedhearingimplantsinsheepcranialbone AT petermonksfield longtermosseointegrationoflaserablatedhearingimplantsinsheepcranialbone AT peterthomsen longtermosseointegrationoflaserablatedhearingimplantsinsheepcranialbone AT anderspalmquist longtermosseointegrationoflaserablatedhearingimplantsinsheepcranialbone |