Multiple autoimmunity and epitope spreading in monozygotic twins
We report clinical, serologic, and immunogenetic studies of a set of monozygotic male twin patients who develop autoimmune thyroiditis and vitiligo associated with the HLA-DRB1*04-DQB1*03:02 and HLA-DRB1*03-DQB1*0201 haplotypes. The patients had detectable anti-thyroid and anti-melanocyte autoantibo...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | Journal of Translational Autoimmunity |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589909021000526 |
| _version_ | 1818967468638470144 |
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| author | Esperanza Avalos-Díaz Elena Pérez-Pérez Julio Granados Deyanira Pacheco-Tovar Juan-José Bollain-y-Goytia-de-la-Rosa Rafael Herrera-Esparza |
| author_facet | Esperanza Avalos-Díaz Elena Pérez-Pérez Julio Granados Deyanira Pacheco-Tovar Juan-José Bollain-y-Goytia-de-la-Rosa Rafael Herrera-Esparza |
| author_sort | Esperanza Avalos-Díaz |
| collection | DOAJ |
| description | We report clinical, serologic, and immunogenetic studies of a set of monozygotic male twin patients who develop autoimmune thyroiditis and vitiligo associated with the HLA-DRB1*04-DQB1*03:02 and HLA-DRB1*03-DQB1*0201 haplotypes. The patients had detectable anti-thyroid and anti-melanocyte autoantibodies. A critical review is presented regarding the role of MHC II molecules linked to clinical manifestations of various autoimmune diseases displayed in a single patient, as is the case in the twin patients reported here. |
| first_indexed | 2024-12-20T13:49:17Z |
| format | Article |
| id | doaj.art-96716d78d7b847b79ee3bf6617c2d4d0 |
| institution | Directory Open Access Journal |
| issn | 2589-9090 |
| language | English |
| last_indexed | 2024-12-20T13:49:17Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Translational Autoimmunity |
| spelling | doaj.art-96716d78d7b847b79ee3bf6617c2d4d02022-12-21T19:38:34ZengElsevierJournal of Translational Autoimmunity2589-90902021-01-014100132Multiple autoimmunity and epitope spreading in monozygotic twinsEsperanza Avalos-Díaz0Elena Pérez-Pérez1Julio Granados2Deyanira Pacheco-Tovar3Juan-José Bollain-y-Goytia-de-la-Rosa4Rafael Herrera-Esparza5Universidad Autónoma de Zacatecas, Department of Immunology, UACB. Guadalupe, Zac, Mexico; Corresponding author. Chepinque 306, Col Lomas de la Soledad. Zacatecas, 98040, Mexico.Universidad Autónoma de Zacatecas, Department of Immunology, UACB. Guadalupe, Zac, MexicoInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Department of Transplantation, Mexico City, MexicoUniversidad Autónoma de Zacatecas, Department of Immunology, UACB. Guadalupe, Zac, MexicoUniversidad Autónoma de Zacatecas, Department of Immunology, UACB. Guadalupe, Zac, MexicoUniversidad Autónoma de Zacatecas, Department of Immunology, UACB. Guadalupe, Zac, MexicoWe report clinical, serologic, and immunogenetic studies of a set of monozygotic male twin patients who develop autoimmune thyroiditis and vitiligo associated with the HLA-DRB1*04-DQB1*03:02 and HLA-DRB1*03-DQB1*0201 haplotypes. The patients had detectable anti-thyroid and anti-melanocyte autoantibodies. A critical review is presented regarding the role of MHC II molecules linked to clinical manifestations of various autoimmune diseases displayed in a single patient, as is the case in the twin patients reported here.http://www.sciencedirect.com/science/article/pii/S2589909021000526AutoimmunityAutoimmune diseasesVitiligoThyroiditisMultiple autoimmunityEpitope spreading |
| spellingShingle | Esperanza Avalos-Díaz Elena Pérez-Pérez Julio Granados Deyanira Pacheco-Tovar Juan-José Bollain-y-Goytia-de-la-Rosa Rafael Herrera-Esparza Multiple autoimmunity and epitope spreading in monozygotic twins Journal of Translational Autoimmunity Autoimmunity Autoimmune diseases Vitiligo Thyroiditis Multiple autoimmunity Epitope spreading |
| title | Multiple autoimmunity and epitope spreading in monozygotic twins |
| title_full | Multiple autoimmunity and epitope spreading in monozygotic twins |
| title_fullStr | Multiple autoimmunity and epitope spreading in monozygotic twins |
| title_full_unstemmed | Multiple autoimmunity and epitope spreading in monozygotic twins |
| title_short | Multiple autoimmunity and epitope spreading in monozygotic twins |
| title_sort | multiple autoimmunity and epitope spreading in monozygotic twins |
| topic | Autoimmunity Autoimmune diseases Vitiligo Thyroiditis Multiple autoimmunity Epitope spreading |
| url | http://www.sciencedirect.com/science/article/pii/S2589909021000526 |
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