Detection of anti-IgE anti-FcεRI α chain auto-antibodies in patients with atopic dermatitis
Anti-IgE and anti-FcεRI α chain auto-antibodies have been detected in the sera of atopic and non-atopic subjects; however, the biological activity of these auto-antibodies is still unclear. These two kinds of autoantibodies were examined in atopic dermatitis (AD) patients. In results, 12 of 92 AD pa...
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Format: | Article |
Language: | English |
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Elsevier
2000-01-01
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Series: | Allergology International |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S132389301531385X |
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author | Satoru Hayashi Hajime Suto Naruhito Wada Hideoki Ogawa Ko Okumura Chisei Ra |
author_facet | Satoru Hayashi Hajime Suto Naruhito Wada Hideoki Ogawa Ko Okumura Chisei Ra |
author_sort | Satoru Hayashi |
collection | DOAJ |
description | Anti-IgE and anti-FcεRI α chain auto-antibodies have been detected in the sera of atopic and non-atopic subjects; however, the biological activity of these auto-antibodies is still unclear. These two kinds of autoantibodies were examined in atopic dermatitis (AD) patients. In results, 12 of 92 AD patients have the anti-IgE, eight have the anti-FcεRI α auto-antibodies and two have both auto-antibodies. Furthermore, biological characterization of these auto-antibodies has been performed. In results, three of 12 samples with the anti-IgE auto-antibodies exhibited inhibitory activity for IgE-FcεRI α binding. Two of the eight samples with the anti-FcεRI α auto-antibodies and one of the two samples with both auto-antibodies had histamine releasing activity. It is documented here that both anti-IgE and anti-FcεRI α auto-antibodies were detected in some AD patients, some anti-IgE auto-antibodies had inhibitory activity for IgE-FcεRI binding and also histamine releasing activity was detected in the anti-FcεRI α chain auto-antibody. |
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institution | Directory Open Access Journal |
issn | 1323-8930 |
language | English |
last_indexed | 2024-12-20T18:10:05Z |
publishDate | 2000-01-01 |
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series | Allergology International |
spelling | doaj.art-9671a789f2914471b628ef87c3c6370f2022-12-21T19:30:29ZengElsevierAllergology International1323-89302000-01-01491475410.1046/j.1440-1592.2000.00158.xDetection of anti-IgE anti-FcεRI α chain auto-antibodies in patients with atopic dermatitisSatoru Hayashi0Hajime Suto1Naruhito Wada2Hideoki Ogawa3Ko Okumura4Chisei Ra5Departments of immunology, TokyoDepartments of immunology, TokyoDepartments of immunology, TokyoDepartments of Dermatology, Juntendo University School of Medicine, TokyoDepartments of immunology, TokyoDepartments of immunology, TokyoAnti-IgE and anti-FcεRI α chain auto-antibodies have been detected in the sera of atopic and non-atopic subjects; however, the biological activity of these auto-antibodies is still unclear. These two kinds of autoantibodies were examined in atopic dermatitis (AD) patients. In results, 12 of 92 AD patients have the anti-IgE, eight have the anti-FcεRI α auto-antibodies and two have both auto-antibodies. Furthermore, biological characterization of these auto-antibodies has been performed. In results, three of 12 samples with the anti-IgE auto-antibodies exhibited inhibitory activity for IgE-FcεRI α binding. Two of the eight samples with the anti-FcεRI α auto-antibodies and one of the two samples with both auto-antibodies had histamine releasing activity. It is documented here that both anti-IgE and anti-FcεRI α auto-antibodies were detected in some AD patients, some anti-IgE auto-antibodies had inhibitory activity for IgE-FcεRI binding and also histamine releasing activity was detected in the anti-FcεRI α chain auto-antibody.http://www.sciencedirect.com/science/article/pii/S132389301531385Xatopic dermatitisauto-antibodyhigh affinity IgE receptorimmunoglobulin E |
spellingShingle | Satoru Hayashi Hajime Suto Naruhito Wada Hideoki Ogawa Ko Okumura Chisei Ra Detection of anti-IgE anti-FcεRI α chain auto-antibodies in patients with atopic dermatitis Allergology International atopic dermatitis auto-antibody high affinity IgE receptor immunoglobulin E |
title | Detection of anti-IgE anti-FcεRI α chain auto-antibodies in patients with atopic dermatitis |
title_full | Detection of anti-IgE anti-FcεRI α chain auto-antibodies in patients with atopic dermatitis |
title_fullStr | Detection of anti-IgE anti-FcεRI α chain auto-antibodies in patients with atopic dermatitis |
title_full_unstemmed | Detection of anti-IgE anti-FcεRI α chain auto-antibodies in patients with atopic dermatitis |
title_short | Detection of anti-IgE anti-FcεRI α chain auto-antibodies in patients with atopic dermatitis |
title_sort | detection of anti ige anti fcεri α chain auto antibodies in patients with atopic dermatitis |
topic | atopic dermatitis auto-antibody high affinity IgE receptor immunoglobulin E |
url | http://www.sciencedirect.com/science/article/pii/S132389301531385X |
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