Predictors of Mechanical Thrombectomy for Anterior Circulation Emergent Large-Vessel Occlusion in the Older Adults
Few studies have reported the clinical outcomes of older adult patients with acute anterior circulation large-vessel occlusion (LVO) who underwent mechanical thrombectomy (MT). Therefore, we investigated the safety, functional outcomes, and predictors of MT for anterior circulation LVO in older adul...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-06-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/10760296231184219 |
| _version_ | 1797791181341458432 |
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| author | Guojie Zhai MD Jiaxing Song MS Nizhen Yu MD Changwei Guo MS Shuai Liu MS Chengsong Yue MS Dahong Yang MD Dongjing Xie MS Xiang Liu MS Shuye Yu MS Lei Lei MD |
| author_facet | Guojie Zhai MD Jiaxing Song MS Nizhen Yu MD Changwei Guo MS Shuai Liu MS Chengsong Yue MS Dahong Yang MD Dongjing Xie MS Xiang Liu MS Shuye Yu MS Lei Lei MD |
| author_sort | Guojie Zhai MD |
| collection | DOAJ |
| description | Few studies have reported the clinical outcomes of older adult patients with acute anterior circulation large-vessel occlusion (LVO) who underwent mechanical thrombectomy (MT). Therefore, we investigated the safety, functional outcomes, and predictors of MT for anterior circulation LVO in older adults. We enrolled patients with acute anterior circulation LVO from May 2018 to October 2021 in this retrospective study. Patients were divided into older (≥80 years) and young (<80 years) groups. Multivariable logistic regression analyses determined the safety, functional outcomes, and predictors of MT for anterior circulation LVO. We divided 1182 patients with acute ischemic stroke into young (18-79 years; 1028 patients) and older (≥80 years; 154 patients) groups. Compared with the young group, the older group had more unfavorable functional outcomes and increased mortality ( P = .003). In the older adult patients, lower initial NIHSS score and higher ASPECTS were correlated with good outcomes. On the contrary, higher initial NIHSS score and lower ASPECTS were related to increased mortality. No difference was detected in symptomatic intracranial hemorrhage within 48 h between two groups. Increasing age was associated with lower rates of favorable functional outcomes and higher mortality rates. The lower initial NIHSS score combined with the higher ASPECTS may predict functional outcomes post-thrombectomy in older adults. |
| first_indexed | 2024-03-13T02:15:09Z |
| format | Article |
| id | doaj.art-96721275ee764777942c98150c5ef065 |
| institution | Directory Open Access Journal |
| issn | 1938-2723 |
| language | English |
| last_indexed | 2024-03-13T02:15:09Z |
| publishDate | 2023-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj.art-96721275ee764777942c98150c5ef0652023-06-30T17:03:42ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232023-06-012910.1177/10760296231184219Predictors of Mechanical Thrombectomy for Anterior Circulation Emergent Large-Vessel Occlusion in the Older AdultsGuojie Zhai MD0Jiaxing Song MS1Nizhen Yu MD2Changwei Guo MS3Shuai Liu MS4Chengsong Yue MS5Dahong Yang MD6Dongjing Xie MS7Xiang Liu MS8Shuye Yu MS9Lei Lei MD10 Department of Neurology, , Suzhou Ninth Hospital Affiliated to Soochow University, Suzhou, China Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, China Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, China Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, China Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, China Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, China Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, China Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, China Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, China Department of Neurology, , Suzhou Ninth Hospital Affiliated to Soochow University, Suzhou, China Department of Neurology, Xianyang Hospital of Yan’an University, Xianyang, ChinaFew studies have reported the clinical outcomes of older adult patients with acute anterior circulation large-vessel occlusion (LVO) who underwent mechanical thrombectomy (MT). Therefore, we investigated the safety, functional outcomes, and predictors of MT for anterior circulation LVO in older adults. We enrolled patients with acute anterior circulation LVO from May 2018 to October 2021 in this retrospective study. Patients were divided into older (≥80 years) and young (<80 years) groups. Multivariable logistic regression analyses determined the safety, functional outcomes, and predictors of MT for anterior circulation LVO. We divided 1182 patients with acute ischemic stroke into young (18-79 years; 1028 patients) and older (≥80 years; 154 patients) groups. Compared with the young group, the older group had more unfavorable functional outcomes and increased mortality ( P = .003). In the older adult patients, lower initial NIHSS score and higher ASPECTS were correlated with good outcomes. On the contrary, higher initial NIHSS score and lower ASPECTS were related to increased mortality. No difference was detected in symptomatic intracranial hemorrhage within 48 h between two groups. Increasing age was associated with lower rates of favorable functional outcomes and higher mortality rates. The lower initial NIHSS score combined with the higher ASPECTS may predict functional outcomes post-thrombectomy in older adults.https://doi.org/10.1177/10760296231184219 |
| spellingShingle | Guojie Zhai MD Jiaxing Song MS Nizhen Yu MD Changwei Guo MS Shuai Liu MS Chengsong Yue MS Dahong Yang MD Dongjing Xie MS Xiang Liu MS Shuye Yu MS Lei Lei MD Predictors of Mechanical Thrombectomy for Anterior Circulation Emergent Large-Vessel Occlusion in the Older Adults Clinical and Applied Thrombosis/Hemostasis |
| title | Predictors of Mechanical Thrombectomy for Anterior Circulation Emergent Large-Vessel Occlusion in the Older Adults |
| title_full | Predictors of Mechanical Thrombectomy for Anterior Circulation Emergent Large-Vessel Occlusion in the Older Adults |
| title_fullStr | Predictors of Mechanical Thrombectomy for Anterior Circulation Emergent Large-Vessel Occlusion in the Older Adults |
| title_full_unstemmed | Predictors of Mechanical Thrombectomy for Anterior Circulation Emergent Large-Vessel Occlusion in the Older Adults |
| title_short | Predictors of Mechanical Thrombectomy for Anterior Circulation Emergent Large-Vessel Occlusion in the Older Adults |
| title_sort | predictors of mechanical thrombectomy for anterior circulation emergent large vessel occlusion in the older adults |
| url | https://doi.org/10.1177/10760296231184219 |
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