Elevated renal tissue oxygenation in premature fetal growth restricted neonates: An observational study.
BACKGROUND:Fetal growth restriction (FGR) is associated with an increased risk for kidney disease in later life. Studies reporting on early signs of renal disturbances in FGR are sparse and mostly include invasive measurements, which limit the possibility for early identification and prevention. We...
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| Format: | Article |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6147486?pdf=render |
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| author | Fieke Terstappen Nina D Paauw Thomas Alderliesten Jaap A Joles Daniel C Vijlbrief A Titia Lely Petra M A Lemmers |
| author_facet | Fieke Terstappen Nina D Paauw Thomas Alderliesten Jaap A Joles Daniel C Vijlbrief A Titia Lely Petra M A Lemmers |
| author_sort | Fieke Terstappen |
| collection | DOAJ |
| description | BACKGROUND:Fetal growth restriction (FGR) is associated with an increased risk for kidney disease in later life. Studies reporting on early signs of renal disturbances in FGR are sparse and mostly include invasive measurements, which limit the possibility for early identification and prevention. We aim to investigate whether renal tissue oxygen saturation (rSO2) measured with near-infrared spectroscopy (NIRS) and the derived value fractional tissue oxygen extraction (FTOE) differ between premature FGR and control neonates in the first three days after birth. METHODS:Nine FGR and seven control neonates born <32 weeks of gestation were included. FGR was defined as biometry <p10 combined with prenatal signs of placental insufficiency. Renal rSO2 was measured continuously with NIRS for 72 hours. FTOE was calculated as: (arterial saturation-rSO2)/arterial saturation. Renal artery blood flow (pulsatility and resistance index) was measured within 24 hours after birth. A linear mixed model approach was used (intercept ± slope = r) to analyze the NIRS parameters. RESULTS:Renal rSO2 was higher in FGR neonates compared to controls (94% vs. 83%; pgroup = 0.002). During the first three days after birth, renal rSO2 decreased in FGR neonates and increased in controls (r = -0.25 vs. r = 0.03; pinteraction = 0.001). Renal FTOE was lower in FGR neonates (0.02 vs. 0.14; pgroup = 0.01) and increased slightly during three days after birth, while it remained stable in controls (r = 0.003 vs. r = -0.0001; pinteraction = 0.001). Renal artery blood flow was similar between groups. CONCLUSIONS:FGR neonate kidneys showed higher rSO2 as measured with NIRS and lower derived values of FTOE in the first three days after birth. We speculate that this was caused by either a reduced oxygen consumption due to impaired renal maturation or increased renal oxygen supply. How these observations correlate with short- and long-term renal function needs further investigation before renal NIRS can be implemented in screening and prevention in clinical practice. |
| first_indexed | 2024-12-22T14:56:12Z |
| format | Article |
| id | doaj.art-9672469f0dc04f40959e458c9680f404 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T14:56:12Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-9672469f0dc04f40959e458c9680f4042022-12-21T18:22:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01139e020426810.1371/journal.pone.0204268Elevated renal tissue oxygenation in premature fetal growth restricted neonates: An observational study.Fieke TerstappenNina D PaauwThomas AlderliestenJaap A JolesDaniel C VijlbriefA Titia LelyPetra M A LemmersBACKGROUND:Fetal growth restriction (FGR) is associated with an increased risk for kidney disease in later life. Studies reporting on early signs of renal disturbances in FGR are sparse and mostly include invasive measurements, which limit the possibility for early identification and prevention. We aim to investigate whether renal tissue oxygen saturation (rSO2) measured with near-infrared spectroscopy (NIRS) and the derived value fractional tissue oxygen extraction (FTOE) differ between premature FGR and control neonates in the first three days after birth. METHODS:Nine FGR and seven control neonates born <32 weeks of gestation were included. FGR was defined as biometry <p10 combined with prenatal signs of placental insufficiency. Renal rSO2 was measured continuously with NIRS for 72 hours. FTOE was calculated as: (arterial saturation-rSO2)/arterial saturation. Renal artery blood flow (pulsatility and resistance index) was measured within 24 hours after birth. A linear mixed model approach was used (intercept ± slope = r) to analyze the NIRS parameters. RESULTS:Renal rSO2 was higher in FGR neonates compared to controls (94% vs. 83%; pgroup = 0.002). During the first three days after birth, renal rSO2 decreased in FGR neonates and increased in controls (r = -0.25 vs. r = 0.03; pinteraction = 0.001). Renal FTOE was lower in FGR neonates (0.02 vs. 0.14; pgroup = 0.01) and increased slightly during three days after birth, while it remained stable in controls (r = 0.003 vs. r = -0.0001; pinteraction = 0.001). Renal artery blood flow was similar between groups. CONCLUSIONS:FGR neonate kidneys showed higher rSO2 as measured with NIRS and lower derived values of FTOE in the first three days after birth. We speculate that this was caused by either a reduced oxygen consumption due to impaired renal maturation or increased renal oxygen supply. How these observations correlate with short- and long-term renal function needs further investigation before renal NIRS can be implemented in screening and prevention in clinical practice.http://europepmc.org/articles/PMC6147486?pdf=render |
| spellingShingle | Fieke Terstappen Nina D Paauw Thomas Alderliesten Jaap A Joles Daniel C Vijlbrief A Titia Lely Petra M A Lemmers Elevated renal tissue oxygenation in premature fetal growth restricted neonates: An observational study. PLoS ONE |
| title | Elevated renal tissue oxygenation in premature fetal growth restricted neonates: An observational study. |
| title_full | Elevated renal tissue oxygenation in premature fetal growth restricted neonates: An observational study. |
| title_fullStr | Elevated renal tissue oxygenation in premature fetal growth restricted neonates: An observational study. |
| title_full_unstemmed | Elevated renal tissue oxygenation in premature fetal growth restricted neonates: An observational study. |
| title_short | Elevated renal tissue oxygenation in premature fetal growth restricted neonates: An observational study. |
| title_sort | elevated renal tissue oxygenation in premature fetal growth restricted neonates an observational study |
| url | http://europepmc.org/articles/PMC6147486?pdf=render |
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