Effect of Astaxanthin on Anti-Inflammatory and Anti-Oxidative Effects of Astaxanthin Treatment for Atopic Dermatitis-induced Mice
Background This study sought to determine whether the antioxidant effects of astaxanthin (AST) could have an anti-inflammatory effect to reduce inflammation caused by atopic dermatitis (AD). Methods Using a mouse model of AD induced by phtalic acid (PA), the levels of inflammation, inflammatory agen...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MEDrang Inc.
2021-11-01
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| Series: | Journal of Acupuncture Research |
| Subjects: | |
| Online Access: | http://www.e-jar.org/upload/pdf/jar-2021-00178.pdf |
| _version_ | 1797204475959574528 |
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| author | Jin Woo Park Ho-Sueb Song |
| author_facet | Jin Woo Park Ho-Sueb Song |
| author_sort | Jin Woo Park |
| collection | DOAJ |
| description | Background This study sought to determine whether the antioxidant effects of astaxanthin (AST) could have an anti-inflammatory effect to reduce inflammation caused by atopic dermatitis (AD). Methods Using a mouse model of AD induced by phtalic acid (PA), the levels of inflammation, inflammatory agents, and evidence of antioxidant activity were examined in PA treated mice (n = 3), PA-AST treated mice (n = 3), and a control group of mice (n = 3). This included measurements of ear thickness, levels of mast cells, IgE, inflammatory cytokine, malondialdehyde (MDA), hydrogen peroxide, HO-1, and GPx-1. Results AST treatment significantly prevented inflammation as measured by ear thickness (p < 0.05), mast cell count (p < 0.001), and IgE concentration in the blood (p < 0.001). Levels of TNF-α (p < 0.001), IL-1β (p < 0.001), IL-6 (p < 0.001), and MDA (p < 0.05) were also significantly lower. In addition, GSH levels increased significantly (p < 0.001), and the level of hydrogen peroxide significantly reduced (p < 0.01). The expression of HO-1, GPx-1 increased. Conclusion In this small experimental study, AST acted on inflammatory mechanisms that induced AD, through anti-inflammatory and antioxidant mechanisms, and is a candidate of interest in the clinical treatment of AD. |
| first_indexed | 2024-04-24T08:35:50Z |
| format | Article |
| id | doaj.art-9672acf7417e4c73b29ce37891baaf67 |
| institution | Directory Open Access Journal |
| issn | 2586-288X 2586-2898 |
| language | English |
| last_indexed | 2024-04-24T08:35:50Z |
| publishDate | 2021-11-01 |
| publisher | MEDrang Inc. |
| record_format | Article |
| series | Journal of Acupuncture Research |
| spelling | doaj.art-9672acf7417e4c73b29ce37891baaf672024-04-16T17:13:34ZengMEDrang Inc.Journal of Acupuncture Research2586-288X2586-28982021-11-0138429329910.13045/jar.2021.001782548Effect of Astaxanthin on Anti-Inflammatory and Anti-Oxidative Effects of Astaxanthin Treatment for Atopic Dermatitis-induced MiceJin Woo Park0Ho-Sueb Song1Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Gachon University, Seongnam, KoreaDepartment of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Gachon University, Seongnam, KoreaBackground This study sought to determine whether the antioxidant effects of astaxanthin (AST) could have an anti-inflammatory effect to reduce inflammation caused by atopic dermatitis (AD). Methods Using a mouse model of AD induced by phtalic acid (PA), the levels of inflammation, inflammatory agents, and evidence of antioxidant activity were examined in PA treated mice (n = 3), PA-AST treated mice (n = 3), and a control group of mice (n = 3). This included measurements of ear thickness, levels of mast cells, IgE, inflammatory cytokine, malondialdehyde (MDA), hydrogen peroxide, HO-1, and GPx-1. Results AST treatment significantly prevented inflammation as measured by ear thickness (p < 0.05), mast cell count (p < 0.001), and IgE concentration in the blood (p < 0.001). Levels of TNF-α (p < 0.001), IL-1β (p < 0.001), IL-6 (p < 0.001), and MDA (p < 0.05) were also significantly lower. In addition, GSH levels increased significantly (p < 0.001), and the level of hydrogen peroxide significantly reduced (p < 0.01). The expression of HO-1, GPx-1 increased. Conclusion In this small experimental study, AST acted on inflammatory mechanisms that induced AD, through anti-inflammatory and antioxidant mechanisms, and is a candidate of interest in the clinical treatment of AD.http://www.e-jar.org/upload/pdf/jar-2021-00178.pdfastaxanthinatopic dermatitisanti-inflammation anti-oxidative |
| spellingShingle | Jin Woo Park Ho-Sueb Song Effect of Astaxanthin on Anti-Inflammatory and Anti-Oxidative Effects of Astaxanthin Treatment for Atopic Dermatitis-induced Mice Journal of Acupuncture Research astaxanthin atopic dermatitis anti-inflammation anti-oxidative |
| title | Effect of Astaxanthin on Anti-Inflammatory and Anti-Oxidative Effects of Astaxanthin Treatment for Atopic Dermatitis-induced Mice |
| title_full | Effect of Astaxanthin on Anti-Inflammatory and Anti-Oxidative Effects of Astaxanthin Treatment for Atopic Dermatitis-induced Mice |
| title_fullStr | Effect of Astaxanthin on Anti-Inflammatory and Anti-Oxidative Effects of Astaxanthin Treatment for Atopic Dermatitis-induced Mice |
| title_full_unstemmed | Effect of Astaxanthin on Anti-Inflammatory and Anti-Oxidative Effects of Astaxanthin Treatment for Atopic Dermatitis-induced Mice |
| title_short | Effect of Astaxanthin on Anti-Inflammatory and Anti-Oxidative Effects of Astaxanthin Treatment for Atopic Dermatitis-induced Mice |
| title_sort | effect of astaxanthin on anti inflammatory and anti oxidative effects of astaxanthin treatment for atopic dermatitis induced mice |
| topic | astaxanthin atopic dermatitis anti-inflammation anti-oxidative |
| url | http://www.e-jar.org/upload/pdf/jar-2021-00178.pdf |
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