Anemia and Thrombocytopenia in Acute and Chronic Renal Failure
Background: Acute renal failure describes as a syndrome by rapid decline in the ability of the kidney to eliminate waste products, regulate acid–base balance, and manage water homeostasis. When this impairment is prolonged and entered chronic phase, erythropoietin secretion by this organ is decreasi...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2013-12-01
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| Series: | International Journal of Hematology-Oncology and Stem Cell Research |
| Subjects: | |
| Online Access: | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/438 |
| _version_ | 1797758859092164608 |
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| author | Akbar Dorgalaleh Mohammad Mahmudi Shadi Tabibian Zahra Kashani Khatib Gholam Hossein Tamaddon Esmaeil Sanei Moghaddam Taregh Bamedi Shaban Alizadeh Eshagh Moradi |
| author_facet | Akbar Dorgalaleh Mohammad Mahmudi Shadi Tabibian Zahra Kashani Khatib Gholam Hossein Tamaddon Esmaeil Sanei Moghaddam Taregh Bamedi Shaban Alizadeh Eshagh Moradi |
| author_sort | Akbar Dorgalaleh |
| collection | DOAJ |
| description | Background: Acute renal failure describes as a syndrome by rapid decline in the ability of the kidney to eliminate waste products, regulate acid–base balance, and manage water homeostasis. When this impairment is prolonged and entered chronic phase, erythropoietin secretion by this organ is decreasing and toxic metabolic accumulates and causes hematological changes include decrease of HCT, MCV and RBC and platelet counts. This study evaluates present of anemia and thrombocytopenia in patients with acute and chronic renal failure.
Materials and Methods: This study conducted on 132 patients with renal impairment and also 179 healthy individuals as two separated control groups. Initially patients with renal problem were tested and after confirmation of impairment, patients were divided in two groups, acute with less than 3 months and chronic with more than 3 months renal failure, based on duration of the disease. Then complete blood count performed for each patient and finally obtained data were analyzed by SPSS software.
Results: Comparison between 96 patients with acute and 36 patients with chronic renal failure revealed that severity of anemia (HCT, Hb and MCV) between these two groups were statistically high in comparison with control groups (P>0.05) but thrombocytopenia in patients with chronic renal failure was statistically different from control and the acute ones (P<0.001).
Conclusion: It was recommended that in patients with chronic renal failure, to prevent the risk of bleeding, platelet count should be checked periodically. |
| first_indexed | 2024-03-12T18:35:09Z |
| format | Article |
| id | doaj.art-9673b4b03f1b44768df67af215363034 |
| institution | Directory Open Access Journal |
| issn | 2008-2207 |
| language | English |
| last_indexed | 2024-03-12T18:35:09Z |
| publishDate | 2013-12-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | International Journal of Hematology-Oncology and Stem Cell Research |
| spelling | doaj.art-9673b4b03f1b44768df67af2153630342023-08-02T08:02:50ZengTehran University of Medical SciencesInternational Journal of Hematology-Oncology and Stem Cell Research2008-22072013-12-0174424Anemia and Thrombocytopenia in Acute and Chronic Renal FailureAkbar Dorgalaleh0Mohammad Mahmudi1Shadi Tabibian2Zahra Kashani Khatib3Gholam Hossein Tamaddon4Esmaeil Sanei Moghaddam5Taregh Bamedi6Shaban Alizadeh7Eshagh Moradi8Hematology Department, Allied Medical School, Tehran University of Medical Sciences, Tehran, Iran.Pars Pathobiology laboratory, Minoodasht, Golestan, Iran.Hematology Department, Allied Medical School, Tehran University of Medical Sciences, Tehran, Iran.Hematology Department, Allied Medical School, Tehran University of Medical Sciences, Tehran, Iran.Department of laboratory Sciences, faculty of paramedical sciences, Shiraz University of Medical Sciences and Health Servies, Shiraz, Iran.Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine and Zahedan Regional Educational Blood Transfusion Center, Iran.Parasitology Department, Zahedan University of Medical Sciences, Zahedan, Iran.Hematology Department, Allied Medical School, Tehran University of Medical Sciences, Tehran, Iran.Medical Education Department, Medical Faculty, University of Medical Sciences, Tehran, Iran.Background: Acute renal failure describes as a syndrome by rapid decline in the ability of the kidney to eliminate waste products, regulate acid–base balance, and manage water homeostasis. When this impairment is prolonged and entered chronic phase, erythropoietin secretion by this organ is decreasing and toxic metabolic accumulates and causes hematological changes include decrease of HCT, MCV and RBC and platelet counts. This study evaluates present of anemia and thrombocytopenia in patients with acute and chronic renal failure. Materials and Methods: This study conducted on 132 patients with renal impairment and also 179 healthy individuals as two separated control groups. Initially patients with renal problem were tested and after confirmation of impairment, patients were divided in two groups, acute with less than 3 months and chronic with more than 3 months renal failure, based on duration of the disease. Then complete blood count performed for each patient and finally obtained data were analyzed by SPSS software. Results: Comparison between 96 patients with acute and 36 patients with chronic renal failure revealed that severity of anemia (HCT, Hb and MCV) between these two groups were statistically high in comparison with control groups (P>0.05) but thrombocytopenia in patients with chronic renal failure was statistically different from control and the acute ones (P<0.001). Conclusion: It was recommended that in patients with chronic renal failure, to prevent the risk of bleeding, platelet count should be checked periodically.https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/438Acute renal failureAnemiaChronic renal failureThrombocytopenia |
| spellingShingle | Akbar Dorgalaleh Mohammad Mahmudi Shadi Tabibian Zahra Kashani Khatib Gholam Hossein Tamaddon Esmaeil Sanei Moghaddam Taregh Bamedi Shaban Alizadeh Eshagh Moradi Anemia and Thrombocytopenia in Acute and Chronic Renal Failure International Journal of Hematology-Oncology and Stem Cell Research Acute renal failure Anemia Chronic renal failure Thrombocytopenia |
| title | Anemia and Thrombocytopenia in Acute and Chronic Renal Failure |
| title_full | Anemia and Thrombocytopenia in Acute and Chronic Renal Failure |
| title_fullStr | Anemia and Thrombocytopenia in Acute and Chronic Renal Failure |
| title_full_unstemmed | Anemia and Thrombocytopenia in Acute and Chronic Renal Failure |
| title_short | Anemia and Thrombocytopenia in Acute and Chronic Renal Failure |
| title_sort | anemia and thrombocytopenia in acute and chronic renal failure |
| topic | Acute renal failure Anemia Chronic renal failure Thrombocytopenia |
| url | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/438 |
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